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ProteomicsMass Spectrometry-Driven Epitope Mapping: Application of Diethylpyrocarbonate Covalent Labeling for the Immunotherapeutic Target Programmed Cell Death Protein 1
Monoclonal antibodies (mAbs) have transformed cancer immunotherapy, with anti-PD1 mAbs playing a pivotal role. This study introduces diethylpyrocarbonate covalent labeling-mass spectrometry (DEPC CL-MS) as a rapid and sensitive technique for epitope mapping of PD1, a critical target in mAb developme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-26 | MSV000096536 | MassIVE
UnknownThe Development and Validation of an LC-MS/MS Method for the Determination of Glyphosate, AMPA, and Glufosinate in Honey Following FMOC-Cl Derivatization: Application to Italian Samples.
Not available
S-EPMC12692283 | biostudies-literature
ProteomicsCL-MS OF hE1a (DHTKD1) or G729R hE1a with hE2o
CL-MS OF hE1a (DHTKD1) or G729R hE1a with hE2o to identify the possible difference in the interactions between hE1a-hE2o and G729R hE1a-hE2o
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017792 | Pride
2-oxoadipate dehydrogenase Dhtkd1 
ProteomicsInvestigation of interaction of p97, p37, PPI, SDS22 and Inhibitor-3 using cross-linking mass spectrometry (CL-MS)
In this project we investigated the complexes PPI/SDS22/Inhibitor-3 and p97/p37/PPI/SDS22/Inhibitor-3 by CL-MS using DSBU as crosslinker.
ORGANISM(S): Homo sapiens (Human) 
2024-11-22 | PXD026696 | Pride
Dsbu Ppi Inhibitor-3 Sds22 P97 
ProteomicsDirect evidence of the presence of cross-linked Aβ dimers in the brains of Alzheimer’s disease patients
Brain-derived amyloid-β (Aβ) dimers are associated with Alzheimer´s disease (AD). However, their covalent nature remains controversial. This feature is relevant, as a covalent cross-link would make brain-derived dimers (native dimers) more synaptotoxic than Aβ monomers and would make them suitable c...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD005657 | Pride
Alzheimer’s disease Amyloid-β Oxidative stress Cross-linked dimers 
ProteomicsSingle Cell Immuno-laser Microdissection Coupled to Label-free Proteomics to Reveal the Proteotypes of Human Brain Cells After Ischemia
Cerebral ischemia entails rapid tissue damage in the affected brain area causing devastating neurological disorders. The use of biomarkers in stroke might have a major impact in patients’ management, both in the diagnosis and the prognosis. Thus, the analysis of the brain proteome is a straightforwa...
ORGANISM(S): Homo sapiens (Human) 
2017-12-04 | PXD003519 | Pride
Proteomics Label-free Stroke Brain ischemia Laser micro-dissection Biomarker 
TranscriptomicsLeft atrial tissue of rats exposed to rapid atrial pacing
Sustained atrial tachycardia leads to multiple molecular and cellular effects collectively defined as atrial tachycardia remodeling (ATR). ATR is thought to play a major role in the self-perpetuating nature of atrial fibrillation (AF) and has been a subject of intense research in large mammalian mod...
ORGANISM(S): Rattus norvegicus 
2019-08-01 | GSE126711 | GEO
UnknownEstimated Regional White Matter Hyperintensity Burden, Resting State Functional Connectivity, and Cognitive Functions in Older Adults.
Not available
S-EPMC8799753 | biostudies-literature
ProteomicsCrosslinking Interaction Network of Human Mitochondria
Isolated human mitochondria underwent DSSO crosslinking. Following treatment, the mitochondria were separated into soluble and insoluble fractions. Both fractions were then subjected to multidimensional fractionation, including SCX and hSAX. The fractionated peptides were subsequently analyzed using...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD052832 | Pride
Lc-msms Hsax Fractionation Scx Dsso Mitochondria 
ProteomicsHigh-Throughput Screening of Amyloid Inhibitors via Covalent-Labeling Mass Spectrometry
MS spectra of DEPC modifications on beta-2-microglobulin (b2m) residues under amyloid-forming conditions, with or without 4-hydroxythalidomide.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-25 | MSV000098322 | MassIVE
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