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ProteomicsDeubiquitinating enzymes in human macrophages after Francisella tularensis infection
Ubiquitination/deubiquitination belong to the most important regulatory mechanisms carried out through the attachment/removal of the ubiquitin molecule, respectively. The process is necessary not only to mark molecules for degradation, but also for example to the activation of signaling pathways lea...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043492 | Pride
Human Macrophage Francisella tularensis Lc-ms Host-pathogen 
GenomicsComprehensive landscape of active deubiquitinating enzymes profiled by advanced chemoproteomics
Comprehensive landscape of active deubiquitinating enzymes profiled by advanced chemoproteomics
PRJNA556874 | ENA
UnknownEmerging Role of Deubiquitinating Enzymes (DUBs) in Melanoma Pathogenesis.
Not available
S-EPMC9322030 | biostudies-literature
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD030644 | Pride
Dia The ubiquitin-proteasome system Lc-ms/ms 
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027330 | Pride
Human Pr619 Tak243 U2os His10-ub Ubiquitin Mg132 
ProteomicsDeubiquitinating enzymes and the proteasome regulate unique sets of ubiquitin substrates.
The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown. Using UbiSite technology and inhibitors, we have compared the contributions of the proteasome and DUBs on the ubiquitinom...
ORGANISM(S): Homo sapiens (Human) 
2022-05-23 | PXD027328 | Pride
Human Ubisite Pr619 Tak243 U2os Ubiquitin Mg132 
ProteomicsComprehensive landscape of active deubiquitinating enzymes profiled by advanced chemoproteomics
Enzymes that bind and process ubiquitin, a small 76 amino acid protein, have been recognized as pharmacological targets in oncology, immunological disorders and neurodegeneration. Mass spectrometry technology has now reached the capacity to cover the proteome with enough depth to interrogate entire ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD014391 | Pride
Proteomics Mass spectrometry Deubiquitylating enzymes Chemical biology Isoforms Ubiquitin specific proteases 
UnknownStructure and Function of Viral Deubiquitinating Enzymes.
Not available
S-EPMC7094624 | biostudies-literature
UnknownTargeting deubiquitinating enzymes in cancer stem cells.
Not available
S-EPMC5670729 | biostudies-literature
ProteomicsA ubiquitinome analysis to study the functional roles of the proteasome associated deubiquitinating enzymes USP14 and UCH37
The removal of (poly)ubiquitin (Ub) chains at the proteasome is a key step in the protein degradation pathway that determines which proteins are degraded and ultimately decides cell fate. Specific polyubiquitin linkages may lead to distinct cellular effects, with several linkage types associated wit...
ORGANISM(S): Homo sapiens (Human) 
2022-06-30 | PXD030714 | Pride
Ubiquitinome Ubiquitinomics Silac Quantitative mass spectrometry Usp14 Parallel reaction monitoring Proteasome Deubiquitinase (dub) Ubiquitin Uch37/uchl5 
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