Sort   by:  
 Page size 
ProteomicsUnraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3-D lung epithelial cell model
Pseudomonas aeruginosa chronically infects the lungs of people with cystic fibrosis (pwCF), where it produces a broad range of proteases that impact host immunity and inflammation. While some studies suggest these enzymes induce inflammation and may contribute to the excessive inflammatory response ...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa PAO1 
2025-10-23 | PXD065321 | Pride
Cystic fibrosis Proteomics Inflammation Elastase b Pseudomonas aeruginosa Bacterial proteases Virulence factors 
ProteomicsDoes protein-bound methionine sulfoxide provides a proteomic basis for ageing in beech seeds?
Beech trees produce seeds irregularly, necessitating the storage of these seeds for forestation. Despite the acquisition of desiccation tolerance during development, beech seeds lose viability during long-term storage faster than orthodox-type seeds. Seeds stored for short (3 years) and long (20 yea...
ORGANISM(S): Fagus sylvatica 
2024-05-23 | PXD046531 | Pride
Longevity Methionine sulfoxide reductase Oxidative stress Fagus sylvatica Seed storage 
ProteomicsProteomics- and metabolomics-based analysis of the regulation of germination in Norway maple and sycamore embryonic axes
Norway maple and sycamore belong to the Acer genus and produce desiccation-tolerant and desiccation-sensitive seeds, respectively. We investigated the seed germination process at the imbibed and germinated stages using metabolomic and proteomic approaches to determine why sycamore seeds germinate e...
ORGANISM(S): Fagus sylvatica Acer 
2025-05-07 | PXD058130 | Pride
Seed physiology Acer platanoides Vitamin b. Metabolite profiling Redox status Acer pseudoplatanus Methionine sulfoxide Posttranslational modification 
ProteomicsSerum H-ferritin to Ferritin ratio as a biomarker of HLH in critically ill patients with hyperferritinemia
Ferritin is a sensitive screening parameter to diagnose hemophagocytic lymphohistiocytosis in critically ill patients but lacks specificity. Ferritin is composed of 24 subunits with 2 types of peptide chains: light (FeL) or heavy (FeH). The proportion of H subunit is suggested to increase during hyp...
ORGANISM(S): Homo sapiens (Human) 
2026-03-06 | PXD065102 | Pride
Lc-msms Human Ferritin Serum 
ProteomicsIdentification of RNA-binding proteins involved in Rice yellow mottle virus infection
RNA-binding protein (RBP)-viral RNA interactions are essential for the viral life cycle and host cell. RNA viruses depend on host RBPs to accomplish their biological cycle; however, the compendium of RBPs involved in virus infection has remained poorly characterized. It has been demonstrated that su...
ORGANISM(S): Oryza sativa Indica Group x Oryza nivara 
2025-06-17 | PXD045853 | Pride
Lc-msms Rbps Saps Viruses Rymv Rbpome 
ProteomicsOptimizing efficacy to safety ratio of glucocorticoids in rheumatoid arthritis models by leveraging PPARα agonism
Glucocorticoids remain essential therapies for immune- and inflammatory diseases such as rheumatoid arthritis (RA) but are notorious for their metabolic side effects. Given the anti-inflammatory and metabolically favorable actions of peroxisome-proliferator activated nuclear receptor (PPAR) agonists...
ORGANISM(S): Homo sapiens (Human) 
2026-09-17 | PXD084343 | Pride
Human Gw7647 Ppar Dexamethasone Glucocorticoid hormones Fibroblast-like synoviocytes 
ProteomicsRhoJ controls EMT associated resistance to chemotherapy
The resistance of cancer cells to therapy is responsible for the death of most cancer patients. Epithelial-to-mesenchymal transition (EMT) has been associated with resistance to therapy in different cancer cells. However, the mechanisms by which EMT mediates resistance to therapy remain poorly under...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-13 | PXD038278 | Pride
Cancer Mus musculus (mouse) Cell culture Scc Ap-lc-ms/ms 
ProteomicsSystematic comparative analysis of extracellular vesicles following apoptosis, necroptosis and ferroptosis
The formation of extracellular vesicles (EVs) has emerged as a novel paradigm in cell-to-cell communication during health and disease. According to the type of cell death modalities, the intercellular functions of EVs may be influenced by their biogenesis and composition. To identify a possible EV c...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-12 | PXD039297 | Pride
Necroptosis Extracellular vesicles Ferroptosis Apoptosis Cell death 
ProteomicsCCR1 inhibition sensitizes multiple myeloma cells to glucocorticoid therapy
One of the cornerstone drugs in the treatment of multiple myeloma (MM) are glucocorticoids. Because MM cells hijack the bone marrow microenvironment to obtain growth and survival signals, resistance to glucocorticoid-induced apoptosis emerges, yet, the underlying mechanisms remain poorly characteriz...
ORGANISM(S): Homo sapiens (Human) 
2025-06-18 | PXD055337 | Pride
Myeloma Glucocorticoids Dexamethasone Ccr1 Bx471 
ProteomicsHNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis
Constitutive androstane receptor (CAR) is a xenobiotic nuclear receptor mainly expressed in the liver, where it regulates drug metabolism and energy homeostasis. CAR has emerged as a promising therapeutic target for diabetes, fatty liver disease, and alcoholic liver disease, but it has not been inve...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD062961 | Pride
Lc-msms Clp-induced peritoneal sepsis Mouse Liver 
Sort   by:  
 Page size