Sort   by:  
 Page size 
ProteomicsK-562 GalNAc-T1/2 Bump-and-hole Whole cell lysate proteomics data
Engineered GalNAc-T glycosyltransferases were used to incorporate a chemically modified GalNAc analog into the glycoproteins on the cell surface of K-562 cells. The chemical modification included a bioorthogonal alkyne tag that allowed for introduction of a clickable, acid-cleavable biotin-picolyl-a...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017989 | Pride
Human Mucin Bioorthogonal Galnac-t Click Glycoprotein K-562 
ProteomicsHuman Differentiated SH-SY5Y neuroblastoma cells treated with Granzyme K
Human Differentiated SH-SY5Y neuroblastoma cells treated with 150 nM GrK alone or together with 100 nM SCH79797 PAR-1 inhibitor to evaluate the impact of granzyme K (GrK) on neuronal functions.
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD064640 | Pride
Neuroblastoma Alzheimer's disease Granzyme k Sh-sy5y 
ProteomicsA multivalent OMV vaccine induces broad protection against major K. pneumoniae disease-causing serotypes
Kp‑OMV4 is a multivalent outer membrane vesicle (OMV)–based vaccine generated from four multidrug‑resistant Klebsiella pneumoniae strains expressing the predominant O‑antigen serotypes O1, O2, O3 and O5, which together account for most invasive disease worldwide. OMVs were purified, characterized by...
ORGANISM(S): Klebsiella pneumoniae IS43 
2026-09-29 | PXD072958 | Pride
Lc-ms/sm. k. pneumoniae. omvs 
ProteomicsDesign principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Ubiquitin Cdk12 Molecular glue Cr8 Cyclink Degrader 
ProteomicsThe catalytic mechanism of vitamin K epoxide reduction in a cellular environment
Vitamin K epoxide reductases (VKOR) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle. Previous chemical models assumed that the catalysis of human VKOR (hVKOR) starts from a fully redu...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD020676 | Pride
Human vkor Lc/ms/ms Catalytic mechanism 
ProteomicsThe CDK12-inhibitor CR8 mediates Cyclin K degradation through the CUL4-RBX1-DDB1 E3 ubiquitin ligase
Small molecules have been identified that induce protein-protein interactions between a substrate and a ubiquitin ligase, resulting in targeted protein degradation. Such molecular glue compounds, unlike traditional enzyme inhibitors, act sub-stoichiometrically to catalyse rapid depletion of previous...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016188 | Pride
Cr8 Cyclin k Molecular glue Cdk12 Ubiquitin Crl4ddb1 
ProteomicsThe CDK12-inhibitor CR8 mediates Cyclin K degradation through the CUL4-RBX1-DDB1 E3 ubiquitin ligase
Small molecules have been identified that induce protein-protein interactions between a substrate and a ubiquitin ligase, resulting in targeted protein degradation. Such molecular glue compounds, unlike traditional enzyme inhibitors, act sub-stoichiometrically to catalyse rapid depletion of previous...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016187 | Pride
Crl4 Cr8 Cyclin k Molecular glue Cdk12 Ubiquitin Ddb1 
GenomicsThe DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer (ChIP-seq)
This study was aimed at understanding the genome-wide binding and regulatory role of the DAXX transcriptional repressor, recently implicated in PCa. ChIP-Seq analysis of genome-wide distribution of DAXX in PC3 cells revealed over 59,000 DAXX binding sites, found at regulatory enhancers and promoters...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-68647 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of Daphnia magna exposed to acesulfame K and its photodegradation products against untreated control groups
The experiment investigates how the artificial sweetener acesulfame K and its photodegradation products affect the gene expression in the freshwater invertebrate Daphnia magna. Juvenile D. magna were subjected to an acute immobilization test (OECD Guideline 202) followed by RNA extraction and transc...
ORGANISM(S): Daphnia magna 
2026-09-25 | E-MTAB-17689 | biostudies-arrayexpress
ProteomicsFast Profiling of Protease Specificity reveals similar substrate specificities for cathepsins K, L and S
N-terminal COFRADIC analysis of cathespine K, L and S to obtain the substrate specificity profile of these cysteine cathepsins.
ORGANISM(S): Homo sapiens (Human) 
2015-02-10 | PXD001536 | Pride
Cathespins N-terminal cofradic 
Sort   by:  
 Page size