Sort   by:  
 Page size 
ProteomicsAmbra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks
Here, using mouse squamous cell carcinoma cells, we report a completely new function for the autophagy protein Ambra1 as the first described ‘spatial rheostat’ controlling the Src/FAK pathway. Ambra1 regulates the targeting of active phospho-Src away from focal adhesions into autophagic structures t...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-04 | PXD006002 | Pride
Ambra1 Ifitm3 Trafficking Invasion Src Fak Dynactin 1 
ProteomicsProteomic analysis of IL33-proximal proteins in squamous cell carcinoma cells
Focal adhesion kinase (FAK) is required for the expression of pro-inflammatory genes that inhibit anti-tumour immunity. Here, we show a novel and crucial role for the dual-function cytokine IL33 in FAK-dependent immune evasion. Specifically, nuclear FAK is required for the expression of IL33, the ch...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-06 | PXD007698 | Pride
Fak Transcription Proteomics Tumour growth Lc-ms Il33 Il1rl1 Scc Bioid St2 Chromatin 
ProteomicsCharacterisation of a Hic-5-proximal nuclear interactome
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report th...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-01 | PXD025868 | Pride
Hic-5 Adhesion Nucleus Human 
ProteomicsCharacterisation of a FAK-proximal nuclear interactome
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report th...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-01 | PXD025861 | Pride
Adhesion Nucleus Human Fak 
ProteomicsCharacterisation of FAK- and ILK-dependent nuclear subproteomes
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report that nuclear prote...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD020179 | Pride
Cancer Ilk Adhesion Nucleus Human Fak 
ProteomicsCharacterisation of a nucleo-adhesome
In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report th...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-01 | PXD025870 | Pride
Adhesome Adhesion Nucleus Human 
ProteomicsCharacterisation of the adhesome of patient-derived cutaneous squamous carcinoma cells
Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes (IACs), play key roles in cancer progression and metastasis. We report here systems-level changes in the adhesome during progression of a patient-derived cutaneous squamous cell carcinoma (cSCC). We foun...
ORGANISM(S): Homo sapiens (Human) 
2023-03-25 | PXD021492 | Pride
Cancer Adhesome Adhesion Human 
Sort   by:  
 Page size