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ProteomicsIdentification and analysis of organic matrix proteins from Sycon ciliatum spicules
Identification of organic matrix proteins of spicules using LC-MS/MS to understand the biomineralisation process in sponges, in particular the formation of spicules.
ORGANISM(S): Sycon ciliatum 
2025-03-05 | PXD060105 | Pride
Sycon ciliatum Proteomics Biomineralization Spicules Calcareous sponges 
ProteomicsProteome alterations in Filamin A deficient granulosa cell tumor-derived KGN cells.
The goal of the study was to evaluate consequences of Filamin A deficiency in granulosa cell tumor-derived KGN cells. Therefore, proteomes of WT and Filamin A deficient KGN cells were quantitatively compared using LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD064136 | Pride
Filamin a Kgn-cells Ovarian cancer Granulosa cells 
ProteomicsAnalysis of skeletal muscle from a tailored pig model of Duchenne muscular dystrophy
We recently generated a novel genetically engineered pig model displaying the fundamental biochemical, clinical and pathological hallmarks of human DMD. To get insight into the hierarchy of molecular derangements during progression of muscular dystrophy, we performed a label free proteome analysis o...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2016-09-27 | PXD002918 | Pride
Model organism Dmd Pig Muscle Lc-ms/ms 
ProteomicsProteome analysis of skeletal muscle samples from a porcine model of Duchenne muscular dystrophy treated by somatic gene editing
Duchenne muscular dystrophy (DMD) is caused by genetic deficiency of dystrophin and characterized by massive structural and functional changes of skeletal muscle tissue, leading to terminal muscle failure. In this project, proteomics data from skeletal muscle of a genetically engineered DMD pig mode...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-02-05 | PXD014893 | Pride
Porcine model Duchenne muscular dystrophy Somatic gene editing 
ProteomicsMolecular basis for recognition and deubiquitination of 40S ribosomes by Otu2
Otu2-driven deubiquitylation of ribosomal protein eS7 impacts translational efficiency. Here, authors provide the molecular basis for recognition of monoubiquitinated eS7 on 40S and give mechanistic insights into Otu2’s role in translation reset. In this context quantitative mass spectrometry analys...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-13 | PXD041573 | Pride
Pulldown Translation Ubiquitination Otu2 Ubp3 
ProteomicsImmunoprecipitation of the human cytomegalovirus (HCMV) gHgLgO glycoprotein complex
To investigate interactions of the gHgLgO complex with host cell proteins, anti-gH immunoprecipitations of the complexes of WT HCMV and a gO249 mutant of HCMV were compared.
ORGANISM(S): Homo sapiens (Human) Human cytomegalovirus (HHV-5) (Human herpesvirus 5) 
2025-05-13 | PXD058164 | Pride
Hcmv Infectivity Ghglgo trimer 
ProteomicsThe secretome of skin cancer cells HaCat and A431
Cutaneous squamous cell carcinoma (cSCC) is the most prominent tumor of non-melanoma skin cancers and the most aggressive tumor among keratinocyte carcinoma of the skin, showing a high potential for local invasion and metastasis. The cSCC incidences increased dramatically in recent years and the dis...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2020-04-15 | PXD017536 | Pride
Keratinocytes  mtor  secretome  squamous cell carcinoma 
ProteomicsValosin-containing protein-regulated endoplasmic reticulum stress causes NOD2-dependent inflammatory responses
To detect novel NOD2 interaction partners in the context of IBD, immunoprecipitates from wildtype NOD2 and mutant NOD2 with IBD-causing variants were analyzed using LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2025-03-05 | PXD031539 | Pride
Human Nod2 Immunoprecipitation 
ProteomicsCellular internalization pathways of environmentally exposed microplastic particles
Microplastic particles that occur in the environment are coated with different biomolecules forming an eco-corona on the particles' surface, which could consequently lead to a specific interaction of the constituents of the eco-corona with membrane receptors. To date, it is not fully understood how ...
ORGANISM(S): biofilm metagenome 
2025-03-07 | PXD050078 | Pride
Eco-corona Microplastic 
ProteomicsImproving the proteome coverage of Daphnia magna
To improve proteome coverage in Daphnia, we established an easy-to-use procedure based on the LC-MS/MS of whole daphnids and dissected daphnia guts separately. Using a comprehensive spectral library, generated by gas-phase fractionation (GPF) and a data-independent acquisition method, we identified ...
ORGANISM(S): Daphnia magna Sus scrofa domesticus (domestic pig) 
2022-11-17 | PXD029198 | Pride
Dia Mass spectrometry Gut Aquatic pollution Ecotoxicoproteomics Daphnia 
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