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ProteomicsHuman Differentiated SH-SY5Y neuroblastoma cells treated with Granzyme K
Human Differentiated SH-SY5Y neuroblastoma cells treated with 150 nM GrK alone or together with 100 nM SCH79797 PAR-1 inhibitor to evaluate the impact of granzyme K (GrK) on neuronal functions.
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD064640 | Pride
Neuroblastoma Alzheimer's disease Granzyme k Sh-sy5y 
MetabolomicsLC-HRMS Metabolomics for Untargeted Diagnostic Screening in Clinical Laboratories: A Feasibility Study
Today's high-resolution mass spectrometers (HRMS) allow bioanalysts to perform untargeted/global determinations that can reveal unexpected compounds or concentrations in a patient’s sample. This could be performed for preliminary diagnosis attempts when usual diagnostic processes and targeted ...
2019-06-06 | MTBLS476 | MetaboLights
ProteomicsThe protective effect of docosahexaenoic acid on mitochondria in a SH-SY5Y model of rotenone-induced toxicity
Polyunsaturated fatty acids in particular omega-3 fatty acids, such as docosahexaenoic acid (DHA) are essential nutrients and components of the plasma membrane. They are involved in various processes, among them synaptic development, functionality, integrity and plasticity and are therefore thought ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD049302 | Pride
Dha Proteomics Rotenone Mitochondria Sh-sy5y 
ProteomicsCellular Depletion of Major Cathepsin Proteases in HeLa and SH-SY5Y Cells
Proteins delivered by endocytosis or autophagy to lysosomes are degraded by exo- and endoproteases. In humans there are 15 lysosomal cathepsins (CTS) that act as important physiological regulators. The cysteine proteases CTSB and CTSL and the aspartic protease CTSD are the most abundant lysosomal pr...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD048603 | Pride
Cathepsin Lysosome Hela Sh-sy5y Proteolysis 
MetabolomicsLoss of SPTSSA Impairs Mitochondrial Function and Neuronal Differentiation in SH-SY5Y Neuroblastoma Cells
Sphingolipids are bioactive membrane and signaling lipids that not only shape cellular architecture but also orchestrate a network of interconnected metabolic pathways. Their core building blocks, sphingoid bases, are synthesized by the serine palmitoyltransferase (SPT) complex. At its core, the SPT...
2026-10-09 | MTBLS15875 | MetaboLights
UnknownCooperative Sulfur Transformations at a Dinickel Site: A Metal Bridging Sulfur Radical and Its H-Atom Abstraction Thermochemistry.
Not available
S-EPMC11345757 | biostudies-literature
TranscriptomicsNO001: Kdm5c controls promoter and enhancer activities
The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes like enhancers and promoters differ in their extent of methylation of histone H3 at lysine-4 (H3K4), but it is largely unknown how the different methylation stat...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-38862 | biostudies-arrayexpress
ProteomicsMS Analysis In vivo treatment of YAP1 SH tagged with phosphatase inhibitors
Investigation of YAP1 interactome plasticity via APMS
ORGANISM(S): Homo sapiens (Human) 
2023-03-04 | PXD032218 | Pride
Phospho Yap1 Apms 
MetabolomicsSpecific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast
Glucose as a source of energy is centrally important to our understanding of life. We investigated the cell division-quiescence behavior of the fission yeast Schizosaccharomyces pombe under a wide range of glucose concentrations (0-111 mM). The mode of S. pombe cell division under a microfluidic per...
2017-07-06 | MTBLS316 | MetaboLights
ProteomicsTargeted analysis of PTPN14, YAP1, LATS1 and GFP SH-tagged pulldown
Targeted analysis of YAP1, LATS1 and PTPN14 interactome
ORGANISM(S): Homo sapiens (Human) 
2023-03-04 | PXD032221 | Pride
Yap1 Lats1 Ptpn14 Apms 
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