Sort   by:  
 Page size 
ProteomicsTMT-based phosphoproteomic analysis of ALK-positive patient-derived lung cancer cell lines with GUK1 phospho-null mutation and ALK TKI treatment
The metabolic adaptations observed in cancer are widely recognized, yet the precise mechanisms of how these metabolic adjustments support tumor growth remain unclear. This study explores the impact of guanine nucleotide metabolism on cancer progression in ALK-driven lung cancer. We showed that GUK1 ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD049284 | Pride
Alk Guk1 Phosphoproteomics Non small cell lung cancer 
ProteomicsInvestigating the effect of Aurora Kinase B inhibition in WT and CDH1 mutant primary neuron cultures
Primary cultures of mouse cerebellar granule neurons at DIV2 that were either WT or Cdh1 mutant were treated with and without the Aurora B inhibitor Barasertib and assessed by phosphoproteomic analysis
ORGANISM(S): Mus musculus (Mouse) 
2023-10-12 | PXD045116 | Pride
Phosphoprotemics Proteomics Primary neuron 
ProteomicsPhosphoproteomic analysis of Aurora Kinase B inhibition in WT and Cdh1 mutant RPE1 cells
RPE1 cells that were either WT or Cdh1 mutant were treated with and without the AurKB inhibitor Barasertib, and assessed by phosphoproteomic analysis
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD044042 | Pride
Rpe1 Phosphoproteomics Aurkb 
ProteomicsCategorization of Phosphorylation Site Behavior During the Diauxic Shift in Saccharomyces cerevisiae
Protein phosphorylation has long been recognized as an essential regulator of protein activity, structure, complex formation, and sub-cellular localization among other cellular mechanisms. However, interpretation of the changes in protein phosphorylation is difficult. To address this difficulty, we ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-04 | PXD022741 | Pride
Phosphoproteomics Yeast Diauxic shift 
ProteomicsInvestigation of cerebellum-specific knockouts of CDH1 and APC1
Tissue-specific cerebellum knockouts of Anaphase-promoting complex subunits CDH1 and APC7 were compared to littermate controls to investigate the protein targets of the APC in post-mitotic neurons, as well as the effect of these proteins on the cerebellar phosphoproteome.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-12 | PXD038778 | Pride
Mouse Neurodevelopment Anaphase promoting complex Cerebellum 
ProteomicsProteomic analysis of APC7 KO mouse Cerebella
A proteomic comparison of the cerebella of APC7 KO mice versus controls using TMT11-plex reagents
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD016683 | Pride
Tmt Cerebellum Mouse Apc7 
ProteomicsProteomic Analysis of Mkrn3 WT vs KO mouse brain
Mutations in the E3 ubiquitin ligase Mkrn3 are associated with precocious puberty in humans. In order to determine the targets of Mkrn3, we performed a TMT-based proteomic analysis of Mkrn3 WT vs KO mouse brains.
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD027220 | Pride
Mouse Brain Tmt E3 ubiquitin ligase Precocious puberty 
ProteomicsProteomic comparison of adipose tissue from obese insulin resistant subjects with obese insulin sensitive subjects
Tissues were collected during the Amsterdam (Netherlands) study of Carbohydrate Regulation of Lipid Metabolism ("SODA").  Subjects were divided between those with and without Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD); subjects were further divided by insulin resistance as asse...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD061142 | Pride
Insulin resistance White adipose tissue Visceral adipose Subcutaneous adipose Insulin action 
ProteomicsTMT-proteomics of sorted MC38+ tumor cells with high-fat diet
Obesity is a major cancer risk factor, but the underlying molecular mechanisms are not always known. In this study, we look at proteome remodeling in cancer cells with obesity, comparing tumor cells sorted from mice fed high-fat versus control diet. We conducted 10-plex TMT-proteomics on GFP+ MC38 c...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-16 | PXD019495 | Pride
Obesity Mouse Biological Colorectal cancer 
ProteomicsIdentifying Targets of Pyrvinium Pamoate in Jurkat Cells using PISA
Pyrvinium pamoate, an anthelmintic drug, inhibits mitochondrial biogenesis during initial T-cell activation; however, its molecular target(s) and mechanism of action are unknown. In this study, we treated Jurkat T cell lysate with pyrvinium pamoate (5 nM and 50μM) and used proteome integral solubili...
ORGANISM(S): Homo sapiens (Human) 
2023-08-29 | PXD040663 | Pride
Mitochondria Pyrvinium pamoate Jurkat t cells Pisa 
Sort   by:  
 Page size