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ProteomicsThe temporal profile of activity-dependent presynaptic phospho-signalling reveals long lasting patterns of post-stimulus regulation
Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter release and activates phosphorylation-based signalling. Here, we present the first global temporal profile of presynaptic activity-dependent phospho-signalling, which includes two KCl stimulation levels ...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-01-28 | PXD010007 | Pride
Neuron Phosphorylation Rat Phosphatase Signalling Synaptosome Presynaptic Depolarization Kinase Post-stimulus Pp1 
ProteomicsPhosphoproteomic analysis of mouse neurons with SRPK2 overexpression or knockdown
SRPK2 was identified as a presynaptic protein kinase involved in the regulation of neurotransmitter release. The phosphoproteome of mouse primary neurons was screened, under the conditions of SRPK2 overexpression and SRPK2 knockdown, to identify candidate substrates of SRPK2.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-14 | PXD016636 | Pride
Brain Mouse Phosphorylation Srpk2 
ProteomicsTarget engagement of Tau antibodies induces reversal of proteomic dyshomeostasis in a mouse model of tauopathy
The microtubule-associated protein Tau is a driver of neuronal dysfunction in Alzheimer’s disease and numerous other tauopathies. In this process, Tau initially undergoes subtle changes to its abundance, subcellular localization and a vast array of post-translational modifications, including phospho...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD045799 | Pride
Mouse Alzheimer’s disease Antibody Proteomics Tau Phosphoproteomics Tauopathies 
ProteomicsProteostasis as a fundamental principle of Tau immunotherapy – study in male mice
The microtubule-associated protein Tau is a driver of neuronal dysfunction in Alzheimer’s disease and numerous other tauopathies. In this process, Tau initially undergoes subtle changes to its abundance, subcellular localization and a vast array of post-translational modifications, including phospho...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051830 | Pride
Mouse Alzheimer’s disease Antibody Proteomics Tau Phosphoproteomics Tauopathies 
ProteomicsKetogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki Syndrome
Kabuki syndrome (KS) is a genetic disorder caused by DNA mutations in KMT2D, a lysine methyltransferase that methylates histones and other proteins, and therefore modifies chromatin structure and subsequent gene expression. Ketones, derived from the ketogenic diet, are histone deacetylase inhibitors...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050547 | Pride
Neurodevelopment Tmtpro Butyrate Hydrophilic interaction liquid chromatography Single-cell rna sequencing Lysine methyltransferase Epigenetic Tandem mass tag 
TranscriptomicsHeterologous microarrays for the study of drought stress in Musa
'Systems-wide' approaches such as microarray RNA-profiling are ideally suited to the study of the complex, overlapping responses of plants to biotic and abiotic stresses. However, commercial microarrays are only available for a limited number of plant species and development costs are so substantial...
ORGANISM(S): Musa sp. 
2009-07-04 | E-GEOD-16865 | biostudies-arrayexpress
UnknownRituximab extended schedule or re-treatment trial for low-tumor burden follicular lymphoma: eastern cooperative oncology group protocol e4402.
Not available
S-EPMC4171355 | biostudies-literature
TranscriptomicsTranscription profiling of butanol treated yeast to monitor the transcript level and also the translation status for each RNA
Global restriction of protein synthesis is a hallmark of cellular stress. Using fusel alchohol addition, we monitor the transcript level and also the translation status for each RNA using cycloheximide to freeze elongating ribosomes. Polyribosome fractionation of cell extracts was used to seperate h...
ORGANISM(S): Saccharomyces cerevisiae 
2005-10-01 | E-MEXP-324 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of amino-acid starved yeast cells to monitor the transcript level and also the translation status for each RNA
Global restriction of protein synthesis is a hallmark of cellular stress. Using amino-acid starvation, we monitor the transcript level and also the translation status for each RNA using cycloheximide to freeze elongating ribosomes. Polyribosome fractionation of cell extracts was used to seperate hig...
ORGANISM(S): Saccharomyces cerevisiae 
2005-10-01 | E-MEXP-323 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of renal cancer from the Cancer Genomics of the Kidney (CAGEKID) project
The incidence of renal cell carcinoma (RCC) is increasing worldwide, and its prevalence is particularly high in some parts of Central Europe. The study describes transcriptome sequencing of clear cell RCC (ccRCC), the most common form of the disease, in patients from four different European countri...
ORGANISM(S): Homo sapiens 
2014-10-29 | E-MTAB-3033 | biostudies-arrayexpress
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