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ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066532 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 1)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066475 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 3)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066538 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsCondensin II Activation by the centromeric protein M18BP1
Condensin I and condensin II promote drastic spatial compaction (condensation) of the genome upon mitotic entry. Condensin I binds chromatin only after dissolution of the nuclear envelope in prophase. Conversely, condensin II is nuclear throughout the cell cycle and initiates chromosome condensation...
ORGANISM(S): Homo sapiens (Human) 
2025-07-09 | PXD051886 | Pride
Sda Sulfo-sda Condensin Cryo-em Xl-ms M18bp1 Crosslinking 
Proteomicsphoto-crosslinking mass spectrometry localises SNAPC5 and SNAPC2 in SNAPc
RNA polymerase III (Pol III) is specialized in the transcription of short, functional RNAs, including small nuclear RNAs (snRNAs). At snRNA genes, Pol III is recruited by the snRNA Activating Protein Complex (SNAPc)forming apreinitiation complex (PIC). Uniquely, SNAPc forms PICs with both Pol II and...
ORGANISM(S): Homo sapiens (Human) 
2025-01-06 | PXD053341 | Pride
Poliii Crosslinking ms Xl-ms Rna polymerase iii Cx-ms Snapc Sda 
ProteomicsInsulin synthesis is sustained by readenylation of its own mRNA.
Insulin is an essential regulator of glucose homeostasis in vertebrates, and impairment of its synthesis or action leads to diabetes with severe health complications in humans. It is therefore essential to understand how beta cells control insulin synthesis and secretion, including the transcription...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-07-06 | PXD079616 | Pride
Proteomics Insulin  mrna metabolism  beta cells  tent5  poly(a) tail  type 2 diabetes. Dia 
ProteomicsCrosslinking MS dataset of the Eukaryotic Core m6A Methyltransferase Complex
RNA modifications are critical post-transcriptional regulators of gene expression, impacting diverse biological processes. Among these, N6-methyladenosine (m⁶A ) is the predominant mRNA mark, installed at DRACH motifs by a conserved multi-protein Methyltransferase Complex (MTC). Although structures ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-10-07 | PXD067875 | Pride
Rna methyltransferase Crosslinking ms Rna modification Crosslinking mass spectrometry M6a Xl-ms Meiosis 
ProteomicsNADPH Gating and F-Actin Engagement Define the Structural Bases of MICAL1 Autoinhibition and Activation
Human MICAL1 belongs to the MICAL multidomain protein family exhibiting an unprecedented [AG3.1]actin depolymerizing activity through the NADPH-dependent oxidoreductase reaction catalyzed by their N-terminal flavoprotein domain. Free MICAL1 exists in an autoinhibited state. Its relief upon interacti...
ORGANISM(S): Homo sapiens (Human) 
2026-10-15 | PXD077485 | Pride
Cryo‐electron microscopy Flavoprotein Enzyme structure Actin Enzyme mechanism Crosslinking mass spectrometry Xl-ms Oxidation-reduction 
ProteomicsStructural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses
crosslinking mass spectrometry results for sulfo-SDA crosslinking of human CUL4-NEDD8/ROC1/DDB1/DCAF1-CtD in complex with SAMHD1 and Vpr protein from simian immunodeficiency virus infecting Cercopithecus cephus (SIVmus Vpr)
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD020453 | Pride
Human cullin vpr crosslinking 
ProteomicsMolecular recognition of thyroglobulin by sortilin
Sortilin is a ubiquitous membrane receptor mediating protein trafficking along different cellular routes. In the thyroid gland, sortilin was proposed as a post-endocytic receptor of the thyroid hormone precursor, thyroglobulin (TG). It was reported that sortilin preferably shuttles iodinated TG to t...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD062462 | Pride
Thyroid Sortilin Cryo-em Thyroglobulin Cross-linking mass spectrometry Crosslinking mass spectrometry Crosslinking ms Trafficking Xl-ms Iodination Endocytosis 
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