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ProteomicsStructural proteomics defines a sequential priming mechanism for the progesterone receptor (HDX-MS)
The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR intera...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD056400 | Pride
Hydrogen-deuterium exchange Progesterone receptor Structural proteomics Hdx 
ProteomicsStructural proteomics defines a sequential priming mechanism for the progesterone receptor (XL-MS)
The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR intera...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD056360 | Pride
Xl-ms Progesterone receptor Crosslinking 
ProteomicsRevealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics (XL-MS)
SARS-CoV-2 nsp7 and nsp8 are important cofactors of the RTC, as they interact and regulate the activity of RNA-dependent RNA polymerase and other nspsHere we used solution-based structural proteomic techniques, hydrogen-deuterium exchange mass spectrometry (HDX-MS) and crosslinking mass spectrometry...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-01-12 | PXD026191 | Pride
Sars-cov-2 Xl-ms Nsp7 Nsp8 
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (XL-MS)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033748 | Pride
Nsp7-8 Xl-ms Nsp7-11 Mpro Sars-cov-2 Polyprotein 
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (HDX-MS pulse labeling)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033702 | Pride
Pulse labeling Hdx-ms Mpro Sars-cov-2 Polyprotein 
ProteomicsBiochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro (HDX-MS continuous labeling)
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic, entailing enormous disruption worldwide. Its ~30 kb RNA genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro/nsp5). Polyprotein processing is essen...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2022-12-19 | PXD033698 | Pride
Hdx-ms Mpro Sars-cov-2 Polyprotein Continuous labeling 
ProteomicsHydrogen deuterium exchange epitope mapping of glycosylated epitopes enabled by online immobilized glycosidase
Numerous mAbs are known to recognize N-glycosylated epitopes or to bind in close proximity to an N-glycan site, however, glycosylated protein sites are typically obscured from HDX detection as a result of the inherent heterogeneity of glycans. To overcome this limitation, we covalently immobilized ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD041204 | Pride
Lc/ms-ms Hdx 
ProteomicsHDX-MS Analysis of RORg:RORE:SRC3 Complexes
The retinoic acid receptor-related orphan receptor γ (RORγ) is a ligand-dependent transcription factor that both underpins metabolic and immune functions and provides vantage to manipulate those processes pharmacologically. Despite its importance, our understanding of the ligand-dependent activities...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD025765 | Pride
Protein-dna interaction Rorg Rorg response elements Hydrogen deuterium exchange mass spectrometry Protein-protein interaction Src3 
ProteomicsStructural insights into IMP2 dimerization and RNA binding
IGF2BP2 (IMP2) is an RNA binding protein contributing to tumorigenesis across various cancers as well as to metabolic disorders. With the growing interest in drug discovery efforts targeting IMP2, an understanding of its structural properties and biological behavior are needed. Thus far, only partia...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD049065 | Pride
Imp2 Hdx-ms 
ProteomicsXL-MS Analysis of Recombinant GPR158:RGS7:Gb5 Complex in Detergent Micelles
GPR158 is widely expressed in the brain and have been implicated in depression, cognition, mood and several cancers. GPR158 is also involved in retinal photoreceptor signaling along with it involvement in synaptic organization. GPR158 interact with G-protein regulator-RGS7 and brings it to plasma me...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026603 | Pride
Rgs7 Orphan gpcr Gb5 Gpcr-rgs complex Membrane protein complex Gpr158 G-protein coupled receptor Chemical crosslinking 
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