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ProteomicsHuman Platelet PIP3 Signalosome
Platelets are small, anucleate cells that play an essential role in haemostasis, but can contribute critically to the pathogenesis of cardiovascular disease. Platelets express all four Class I Phosphoinositide 3-kinase (PI3K) isoforms, with previous work revealing important roles for these enzymes ...
ORGANISM(S): Homo sapiens (Human) 
2017-06-06 | PXD003777 | Pride
Lc-msms Platelet Pip3 Pi3k Platelets 
ProteomicsChemical degradation of BTK/TEC as a novel approach to inhibit platelet function.
Determination of the effect of the generic tyrosine kinase degrader TL12-186, and the BTK degraders DD-04-15 and DD-03-171 on human platelet protein content and function.
ORGANISM(S): Homo sapiens (Human) 
2023-03-02 | PXD034440 | Pride
Human Platelet Targeted protein degradation Btk Protac Tec 
ProteomicsSelective degradation of platelet BTK by the PROTAC NX-5948
This study presents a tandem mass tag (TMT)–based quantitative proteomic analysis of human platelets treated with the BTK degraders NX-2127 or NX-5948, or vehicle control (DMSO). Washed platelet lysates from three independent biological replicates per condition were digested with trypsin, labelled w...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD072863 | Pride
Human Nx-2127 Quantitative proteomics Nx-5948 Sps-ms3 Tmt Btk Protac Thrombosis Platelets 
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