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UnknownRacial/ethnic disparities in hypertension prevalence: reconsidering the role of chronic stress.
Not available
S-EPMC3910029 | biostudies-literature
TranscriptomicsER stress increases alternative splicing of SRFS3’s poison exon.
Mouse fibroblasts stressed with 1mM dithiothreitol for 4 hours were interogated for stress-induced alternative mRNA spliceforms mRNA-Seq Untreated fibroblasts versus dithiothrietol stressed fibroblasts; wild-type, Ire1α-null and Xbp1-null lines were compared.
ORGANISM(S): Mus musculus 
2016-07-16 | E-GEOD-84450 | biostudies-arrayexpress
ProteomicsE2~dID: A versatile approach to identify substrates modified with ubiquitin and ubiquitin-like molecules by specific E3 enzymes
Covalent modifications of proteins with ubiquitin and ubiquitin-like molecules are instrumental to most, if not all biological processes. However, identifying the E3 ligase responsible for these modifications remains a major bottleneck in ubiquitin research. Here, we have developed an E2-thioester-d...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2019-04-03 | PXD008624 | Pride
Ubiquitin Ap-ms Tmt 
ProteomicsDIPG harbour alterations targetable by MEK inhibitors, with acquired resistance mechanisms overcome by combinatorial inhibition
The survival of children with DIPG remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment failure. In a prospective biopsy-stra...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD019701 | Pride
Lc-msms Tmt Clinical Dipg 
ProteomicsHMGB1 interactome in prostate and ovarian cancer cells
This study reports the interactome of HMGB1 in prostate and ovarian cancer cells, which includes a variety of proteins involved in diverse cellular processes. Subcellular fractionation is used to map the distribution of interacting proteins. In the nucleus, HMGB1 interacts directly with NuRD complex...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026258 | Pride
Septin Thoc complex Prostate cancer Ovarian cancer Ribosome biogenesis Hmgb1 Skov-1 Nurd complex Rab11 Pc3 
ProteomicsHMGB1 interactome in prostate and ovarian cancer cells treated with cisplatin
Cisplatin is used in chemotherapy of prostate, ovary and other cancer types but unfortunately the efficiency of cisplatin treatment is frequently hampered by acquired resistance. The cytotoxic effect of cisplatin has been attributed to its binding to DNA. HMGB1 is able to bind to cisplatin-DNA adduc...
ORGANISM(S): Homo sapiens (Human) 
2021-11-01 | PXD026309 | Pride
Pc-3 Prostate cancer Ovarian cancer Skov-3 Cisplatin Hmgb1 Interactome 
UnknownCytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis.
Not available
S-EPMC9852471 | biostudies-literature
ProteomicsCharacterisation of Myst2 and Niam interactomes in mouse embryonic stem cells
Here we undertake the characterisation of Myst2 protein interactions in mouse embryonic stem cells by affinity purification and mass spectrometry using a Myst2-FTAP tagged cell line. This protein interaction study confirms that in mouse embryonic stem cells Myst2 is part of H3 and H4 histone acetyla...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-22 | PXD005987 | Pride
Blue native page Niam Protein interactions Affinity purification Myst2 Embryonic stem cells 
TranscriptomicsGene expression changes in feeding female and male lone star ticks, Amblyomma americanum (L)
A collection of 1145 clones from an EST project on female tick salivary gland genes was hybridized on glass slides to RNA extracted from several feeding stages of adult female tick salivary glands, including unfed and replete, and from adult male ticks, either unfed or fed in the presence or absence...
ORGANISM(S): Amblyomma americanum 
2010-06-11 | E-GEOD-5010 | biostudies-arrayexpress
ProteomicsUbiquitin-mediated modulation of necroptotic effector MLKL
We aimed to identify lysine (K) residues that are endogenously ubiquitylated upon TNF-induced necroptosis. To this end, we used a quantitative mass spectrometry-based approach. Briefly, MDFs were treated with TSZ or left untreated and protein lysates were digested with trypsin into peptides. Ubiquit...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-13 | PXD018857 | Pride
Ubiquitin Tmt Cancer Mlkl Mouse Msms 
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