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ProteomicsMultiparametric characterization of red blood cells physiology after hypotonic dialysis based drug encapsulation process.
Red blood cells (RBC) can act as carriers for therapeutic agents and given their biocompatibility and long lifespan in the circulation, they can substantially improve the safety, pharmacokinetics, and pharmacodynamics of many drugs. Maintaining RBC integrity and lifespan is important for the efficac...
ORGANISM(S): Homo sapiens (Human) 
2021-11-29 | PXD022549 | Pride
Orbitrap fusion Characterization Human red blood cells Hemoglobin-based absolute and global quantification Hypotonic dialysis Drug carriers 
UnknownMultiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process.
Not available
S-EPMC9279626 | biostudies-literature
TranscriptomicsA Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with .10% of these being fatal. Leptospires can survive for weeks in suitably moist conditions b...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2014-03-20 | E-GEOD-53818 | biostudies-arrayexpress
UnknownInterventions for chronic non-hypovolaemic hypotonic hyponatraemia.
Not available
S-EPMC6513194 | biostudies-literature
ProteomicsSAMD1 suppresses epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma.
SAMD1, a CpG island-binding protein, plays a pivotal role in the repression of its target genes by influencing the activity of KDM1A. Despite its significant correlation with outcomes in various tumor types, SAMD1's role in cancer has remained largely unexplored. In this study, we focus on pancreati...
ORGANISM(S): Homo sapiens (Human) 
2024-07-12 | PXD044104 | Pride
Cancer Epithelial-mesenchymal transition Cpg islands N-cadherin Fbxo11 Samd1 Kdm1a Chromatin Pancreatic ductal adenocarcinoma 
UnknownFabrication of Red Blood Cell-Based Multimodal Theranostic Probes for Second Near-Infrared Window Fluorescence Imaging-Guided Tumor Surgery and Photodynamic Therapy.
Not available
S-EPMC6376196 | biostudies-literature
ProteomicsSMAD2/3 interactome in human pluripotent stem cells
This experiment was designed to determine the interactome of SMAD2/3 in human pluripotent stem cells (hPSCs). hPSCs were cultured in standard pluripotency-promoting conditions, or induced to differentiate towards the definitive endoderm lineage for 36h. Endogenous SMAD2/3 was immunoprecipitated from...
ORGANISM(S): Homo sapiens (Human) 
2018-01-04 | PXD005285 | Pride
Smad2/3 Human pluripotent stem cells 
GenomicsCo-regulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers
In mammalian cells transcription factors (TFs) preferentially bind sites contained in regions of high nucleosomal occupancy, as determined by nucleotide-dependent computational analysis. This observation suggests that nucleosomes may act as gatekeepers of TF binding sites. We hypothesized that in ma...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-50762 | biostudies-arrayexpress
ProteomicsPax3 interactome in mouse ES cell-derived mesodermal precursors
The skeletal myogenic lineage in developing embryos is specified within the somites and requires members of the Paired box (Pax) family of transcription factors. In particular, Pax3 is the first member of this family expressed in the central region of the dermomyotome and it is necessary for specifi...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-18 | PXD012693 | Pride
Lc-msms Embryoid bodies Affinity purification Pax3 Nuclear extract Mouse Myogenesis Mesoderm 
ProteomicsAndrogen-sensitive glycomembrane protein expression in LNCaP prostate tumor cells
Aberrant androgen receptor (AR)-mediated transcription is a critical driver in progression of human prostate cancer. It's known that different doses of androgens can elicit differential transcriptional and proliferative responses in prostate-tumor cells. Here, we set out to examine the androgenic re...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD002913 | Pride
Androgen Human prostate cancer cells Lectin affinity purification 
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