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ProteomicsRhomboid mediates membrane protein quality control as an intramembrane protease and adaptor of AAA protease.
Magnesium homeostasis is essential for life and depends on magnesium transporters whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom but their functions are largely elusive. Using proteomics we find that Bacillus subtili...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-01-09 | PXD014578 | Pride
Transporter Er associated degradation Intramembrane protease Manganese Tripletof 5600 Magnesium Bacillus subtilis Lipid membrane Gelc-ms/ms Rhomboid protease Proteostasis Zinc 
ProteomicsSelective regulation of aspartyl intramembrane protease activity by calnexin
Signal peptide peptidase-like 2c (SPPL2c) is a testis-specific aspartyl intramembrane protease that contributes to male gamete function both by catalytic and non-proteolytic mechanisms. Here, we provide an unbiased characterisation of the in vivo interactome of SPPL2c identifying the ER chaperone ca...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052965 | Pride
Co-ip Signal peptide peptidase-like 2c Mouse Calnexin Sppl2c Testis 
ProteomicsIdentification of candidate interactors of Bacillus subtilis rhomboid protease YqgP
Magnesium homeostasis is essential for life and depends on magnesium transporters whose activity and ion selectivity needs to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom but their functions are largely elusive. Using proteomics we find that Bacillus subtil...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-01-09 | PXD014566 | Pride
Transporter Intramembrane protease Co-immunoprecipitation Lipid membrane Rhomboid protease Proteostasis Lc-ms/ms 
UnknownIdentification of an archaeal presenilin-like intramembrane protease.
Not available
S-EPMC2947513 | biostudies-literature
ProteomicsN-terminome analyses of the intramembrane-cleaving protease SPPL3
The intramembrane protease SPPL3 can specifically cleave select Golgi enzymes, enabling their secretion and concomitantly altering global cellular glycosylation, yet the entire range of Golgi glycan-modifying enzymes cleaved by SPPL3 under physiological conditions remains to be defined. Here, we est...
ORGANISM(S): Homo sapiens (Human) 
2022-03-17 | PXD028769 | Pride
Hek293 Label-free Hela Sppl3 N-terminomics 
UnknownOpen-cap conformation of intramembrane protease GlpG.
Not available
S-EPMC1892946 | biostudies-literature
ProteomicsIdentification of naturally short gamma-secretase substrates
The intramembrane protease gamma-secretase has broad physiological functions, but also contributes to Notch-dependent tumors and Alzheimer’s disease. To identify naturally short substrates and non-substrates of gamma-secretase, we used four human cell lines of different tissue origins, breast cancer...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD045701 | Pride
Dapt Human Gamma-secretase Intramembrane protease 
ProteomicsEscherichia coli S2P family intramembrane protease RseP is engaged in the regulated sequential cleavages of FecR in the ferric citrate signaling
Escherichia coli RseP, a member of the S2P family intramembrane proteases, is involved in the activation of the σE extracytoplasmic stress response and the elimination of remnant signal peptides. It remains however unclear whether RseP has additional cellular functions. In this study, we attempted t...
ORGANISM(S): Escherichia Coli 
2021-04-14 | PXD023797 | JPOST Repository
UnknownArchitectural and thermodynamic principles underlying intramembrane protease function.
Not available
S-EPMC4028635 | biostudies-literature
Unknownm-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria.
Not available
S-EPMC1783466 | biostudies-literature
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