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ProteomicsInvestigating the target and off-target landscape of PLK1 small molecule inhibitor volasertib
In this study we aimed to identify off-targets of polo-like kinase 1 (Plk1) small molecule inhibitor volasertib. Plk1 is an important cell cycle kinase and an attractive target for anticancer treatment. Volasertib is ATP-competitive small molecules that may also block the ATP-pocket of other protein...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD024040 | Pride
Volasertib Lc-ms Leukemia Plk1 
ProteomicsThermal proteome profiling of childhood ALL cell lines for proteoform detection
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and it has a 5-year survival rate of 85% for European children. But for subsets of patients who fail to respond to standard of care chemotherapeutics, treatment options are limited, and clinical prognosis is poor. To establish a...
ORGANISM(S): Homo sapiens (Human) 
2023-03-20 | PXD031162 | Pride
Proteoforms Tpp Cetsa Lc-msms All 
ProteomicsInvestigating the target and off-target landscape of PLK1 small molecule inhibitor volasertib
In this study we aimed to identify off-targets of polo-like kinase 1 (Plk1) small molecule inhibitor volasertib. Plk1 is an important cell cycle kinase and an attractive target for anticancer treatment. Volasertib is ATP-competitive small molecules that may also block the ATP-pocket of other protein...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD023757 | Pride
Drug Tpp Lc-ms Leukemia 
ProteomicsDevelopment of novel chemical inhibitors of SETD8
SETD8 is a histone methyltransferase that catalyzes the monomethylation of histone H4K20. Overexpressed in cancer, several studies have suggested that it could be a potential target for treatment in certain tumors. However, there are currently very few SETD8 inhibitors, and all of them have bad phar...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051199 | Pride
Drug targets Thermal proteoome profiling Cancer 
ProteomicsProteomics analysis of childhood acute lymphoblastic leukemia cell lines reveals novel drug vulnerabilities
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and it has a 5-year survival rate of 85% for European children. But for subsets of patients who fail to respond to standard of care chemotherapeutics, treatment options are limited, and clinical prognosis is poor. To establish a...
ORGANISM(S): Homo sapiens (Human) 
2022-03-26 | PXD023662 | Pride
Hirief Lc-msms All 
ProteomicsNew antiviral small molecule inhibitors disturb interactions between cellular HSP70 and virus proteins
RNA virus outbreaks such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), Ebola virus (EBOV) and Zika virus (ZIKV) causing worldwide health emergencies have highlighted the urgent need of new antiviral strategies. Upon outbreaks with new, unmet viruses where knowledge of virus biology...
ORGANISM(S): Homo sapiens (Human) Filoviridae Ebolavirus 
2021-01-04 | PXD021494 | Pride
Antiviral compound 2d-tpp Virus proteins Tpp Lc-msms 
Proteomicsthermal proteome profiling of hypomethylating agents in infant ALL
thermal proteome profiling of hypomethylating agents in infant ALL for elucidation of their mode of action.
ORGANISM(S): Homo sapiens (Human) 
2022-11-15 | PXD030539 | Pride
Decitabine Azacitidine Tpp Human Lc-ms/ms 
ProteomicsBioactivatable inhibitor of ubiquitin-dependent proteasomal degradation
The hyperactive state of malignant cells results in the production of an excess of aberrant proteins that challenge the clearing capacity of the ubiquitin-proteasome system (UPS), resulting in an increased sensitivity towards drugs that reduce the efficacy of this critical proteolytic system. In thi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD019519 | Pride
Pulldown Click-chemistry Ups Upr Lc-msms 
ProteomicsProteogenomics of High hyperdiploid childhood acute lymphoblastic leukemia
Proteogenomic analysis and genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of High hyperdiploid childhood acute lymphoblastic leukemia.
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD010175 | Pride
Lc-ms/ms Human Leukemia Proteogenomics 
ProteomicsProteogenomic subtyping of acute myeloid leukemia and ex-vivo drug response profiling for precision therapies.
We have performed a comprehensive proteomic analysis of clinical patient samples of acute myeloid leukemia (AML) alongside genome-, transcriptome- and ex-vivo drug response profiling.
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD061758 | Pride
Aml Cancer Proteomics Leukemia Drug screening Therapy 
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