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ProteomicsExperience-induced remodeling of the hippocampal post-synaptic proteome and phosphoproteome
The postsynaptic density (PSD) of excitatory synapses contains a highly organized protein network with thousands of proteins and is key node in the regulation of synaptic plasticity. To gain new mechanistic insight into experience-induced changes in the PSD, we examined the global dynamics of the hi...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD045496 | Pride
Proteomics Mouse Phosphoproteomics 
Proteomicsdb/db - Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia
the phosphoproteomic landscape of beta-cell adaptive flexibility after exposure to glucose
ORGANISM(S): Mus musculus (Mouse) 
2019-07-22 | PXD010265 | Pride
Obesity Db/db Beta-cell Phosphoproteomics Diabetes 
ProteomicsHuman hippocampus LC-MSMS
Large-scale analysis of post-translational modification in the hippocampus of patients with Alzheimer's disease using pI shift and label free quantification without enrichment.
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD000950 | Pride
Human brain hippocampus lc-msms 
ProteomicsProtective impact on the apoptotic pathway by suppressing DMT1 during inflammatory stress
We performed phosphoproteomics using our sequential enrichment strategy of mRNA, protein, and phosphopeptides, which enabled us to explore the concurrent molecular events in the same sample and at the same time in normal and DMT1 silencing insulin-producing β-cells stimulated by siRNAs.
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2021-08-10 | PXD017216 | Pride
Degradation pathway Ros Oxidative stress Diabetes Signaling 
ProteomicsCellular signaling underlying GSIS in pancreatic β-cells
In the present study, we investigated signaling pathways associated with GSIS in freshly isolated rat Islets of Langerhans. Specifically, our aim was to reveal which phosphosites and N-linked sialylated glycosylation sites that were reversible regulated upon brief glucose stimulation and link these ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2017-11-14 | PXD007689 | Pride
Beta-cells Lc-msms Gsis Rat Islets 
ProteomicsCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice
Obesity-linked type 2 diabetes (T2D) is a major health problem of global epidemic proportions. The onset of T2D is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to o...
ORGANISM(S): Mus Musculus 
2020-05-18 | PXD016392 | panorama
ProteomicsCharacterization of signaling pathways associated with pancreatic beta-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db miceCharacterization of signaling pathways associated with pancreatic β-cell adaptive flexibility in compensation of obesity-linked diabetes in db/db mice
To characterize the signaling mechanisms underlying beta-cell dysfunction in db/db mice and their return to a more “normal” beta-cell phenotype, we applied a mass spectrometry-based quantitative phosphophoproteomics and sialiomics(sialylated N-linked glycopeptides) approach to normal and db/db beta-...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-19 | PXD017469 | Pride
Beta-cells Obesity Islets Diabetes 
ProteomicsDynamic changes in the protein localization in the nuclear environment in pancreatic β-cell after brief glucose stimulation
We focus on the characterization of proteins in the nuclear environment of β-cells after brief, high glucose-stimulation. We compared purified nuclei derived from β-cells stimulated with 17mM glucose for 0, 2, and 5 minutes using quantitative proteomics, a time frame that most likely does not result...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-03-12 | PXD008988 | Pride
Lc-msms Pancreatic beta-cells Gsis Nucleus 
ProteomicsExportin 1 modulates lifespan by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP
Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and lifespan, we systematically analyzed the impact of nuclear export on prot...
ORGANISM(S): Caenorhabditis elegans 
2026-02-23 | PXD027230 | Pride
Autophagy Proteomics Aging Proteostasis 
ProteomicsnextPP for chromosome-based proteomic research using neXtProt and GENCODE databases
In this study, we introduce a streamlined pipeline using customized and concatenated GENCODE and neXtProt databases with controlled false discovery rate (FDR) for finding GENCODE ASVs and missing proteins while mapping onto single amino acid variants (SAAVs) from Hippocampal dataset.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-07-25 | MSV000081385 | MassIVE
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