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ProteomicsAMPylation Regulates 5'-3' Exonuclease PLD3 processing
The 5’-3’ exonuclease phospholipase D3 (PLD3) is a type II transmembrane protein undergoing sequential post-translational modifications (PTM) by N-glycosylation, AMPylation and proteolytic cleavage. The substrates of PLD3 5’-3’ exonuclease activity are single-stranded DNAs and RNAs, which act as lig...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD057707 | Pride
Pld3 Ampylation Chemical proteomics Protein post-translational modifications 
ProteomicsIdentification of USP39 Ligands and Their Application in Targeted Protein Degradation
Alternative splicing is a tightly regulated process essential for transcriptomic and proteomic diversity, and its dysregulation has been implicated in various cancers. Ubiquitin-specific protease 39 (USP39) is a core component of the spliceosome that lacks enzymatic activity, rendering it challengin...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD065738 | Pride
Human Usp39 Protac 
ProteomicsTransforming chemical proteomics into high-throughput method using SP2E workflow.
Protein post-translational modifications (PTMs) play a critical role in regulation of protein catalytic activity, localization and protein-protein interactions. An attachment of PTMs onto proteins significantly diversify their structure and function resulting in so called proteoforms. However, the s...
ORGANISM(S): Homo sapiens (Human) 
2022-07-04 | PXD033644 | Pride
Method development Ampylation 
ProteomicsAMPylation profiling during neuronal differentiation reveals extensive variation on lysosomal proteins
Protein AMPylation is a prevalent posttranslational modification with an emerging role in neurodevelopment and neurodegeneration. Although in metazoans the two highly conserved protein AMP-transferases together with diverse group of AMPylated proteins have been identified using chemical proteomics a...
ORGANISM(S): Homo sapiens (Human) 
2021-12-01 | PXD023873 | Pride
Lysosome Ampylation 
ProteomicsDecrypting the functional design of unmodified translation elongation factor P
Stalling of ribosomes due to consecutive proline motifs during polypeptide synthesis is a challenge faced by organisms across all kingdoms. To overcome this, bacteria employ translation elongation factor P (EF-P), while archaea and eukaryotes rely on a/eIF5A. Typically, these elongation factors beco...
ORGANISM(S): Weeksella virosa Rhodomicrobium vannielii ATCC 17100 Escherichia coli 
2024-04-08 | PXD044929 | Pride
Post-translational modification Translation elongation factor Ribosome stalling Polyproline-containing proteins 
ProteomicsPronucleotide probe for in vivo imaging of protein AMPylation.
Protein AMPylation is a prevalent posttranslational modification in human cells involved in the regulation of unfolded protein response and neural development. Here we present a novel pro-N6azA probe suitable for in vivo imaging and chemical proteomics profilling of AMPylated proteins. The pro-N6azA...
ORGANISM(S): Homo sapiens (Human) 
2019-12-10 | PXD016011 | Pride
Chemical proteomics Ampylation 
ProteomicsFICD activity and AMPylation remodelling modulate human neurogenesis
The AMPylation is novel protein post-translation modification. In consist of attachment of the adenosine monophosphate onto the serine, threonine or tyrosine amino acid residues of the protein. This process is catalysed by bacterial effectors or in human by protein FICD (also called HYPE) which cont...
ORGANISM(S): Homo sapiens (Human) 
2019-12-04 | PXD015062 | Pride
Chemical-proteomics Cerebral organoids. Phosphoramidate prodrugs Ficd Ampylation Neuronal development 
ProteomicsECE2 regulates Neurogenesis and Neuronal Migration during Cortical Development.
During embryonic development, the cerebral cortex is equipped with excitatory projection and inhibitory interneurons that migrate in organized layers. Periventricular heterotopia (PH) is a rare and heterogeneous disorder in which a subpopulation of new-born projection neurons fails to initiate their...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD015571 | Pride
Ce2 Periventricular heterotopia Cerebral organoids Embryonic development 
ProteomicsChemical proteomics reveals protein tyrosination extends beyond the alpha-tubulins in human cells.
Tubulin detyrosination-tyrosination cycle regulates the stability of microtubules. Thus far described on α-tubulins, the tyrosination level is maintained by a single tubulin-tyrosine ligase (TTL). However, the precise dynamics and tubulin isoforms which undergo (de)tyrosination in neurons are unknow...
ORGANISM(S): Homo sapiens (Human) 
2022-10-20 | PXD037402 | Pride
Ingns Dia-nn Tyrosination Sp2e Sh-sy5y 
ProteomicsVimentin network dysregulation mediates neurite deficits in SNCA duplication Parkinson’s patient-derived midbrain neurons
Duplication of the SNCA gene (SNCADupl), linked to elevated levels of alpha-synuclein (aSyn), is a genetic cause of Parkinson's disease (PD). Our prior work with human-induced pluripotent stem cell (hiPSC)-derived midbrain neurons generated from PD SNCADupl patients identified neuritic deficits, acc...
ORGANISM(S): Homo sapiens (Human) 
2025-07-16 | PXD063433 | Pride
Snca Midbrain neurons Parkinsons disease Vimentin 
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