Sort   by:  
 Page size 
ProteomicsGRASPing experience-dependent protein expression signatures enriched for hippocampal engram cell synapses
Enhanced synaptic wiring onto sparsely distributed memory engram cells supports contextual memory storage and recall, with negative-valence memories exhibiting greater salience. Protein-level adaptations of input-specific synaptic connectivity onto hippocampal CA1 engram cells, however, remains larg...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-24 | PXD054892 | Pride
ProteomicsComparative analyses of data independent acquisition mass spectrometric approaches: DIA, WiSIM-DIA and directDIA
With a multitude of DIA approaches developed recently, many of their features are not yet well explored. In this study we make use of a biologically relevant sample, the synaptosome, as a model to compare the spectral libraries generated by (1) DDA solely on Orbitrap (OT), (2) Orbitrap for MS1 scan...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-20 | PXD006934 | Pride
Wisim-dia Lc-ms/ms Dia Wisim Dda Directdia 
ProteomicsComparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins
Key to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynam...
ORGANISM(S): marmosets Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-22 | PXD009251 | Pride
Synapse Species Proteomics Rat Marmoset Human Synaptosome Mouse Swath 
ProteomicsThe proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
By combining immunohistochemistry (IHC) and laser microdissection (LMD) we isolated neurons with GVD and those bearing tangles separately from human post-mortem AD hippocampus (n=12) using their typical markers casein kinase (CK)1δ and phosphorylated tau (AT8). Control neurons were isolated from cog...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023199 | Pride
Alzheimer´s disease Neurofibrillary tangles Granulovacuolar degeneration Tau Neuropathology Proteomics 
ProteomicsMultimodal Proteomics reveals dysregulated secretion and ECM remodeling in schizophrenia patient iPSC-derived astrocytes
Astrocytes are increasingly implicated in the pathophysiology of schizophrenia (SCZ), yet how astrocytic dysfunction contributes to disease-relevant neuronal abnormalities remains unclear. Here, we use mass spectrometry–based proteomics to profile lysates (proteome) and secreted (secretome) proteins...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD075039 | Pride
Astrocytes Proteomics Ipsc Schizophrenia Protein secretion 
ProteomicsCorrelation profiling of synaptic sub-fraction proteomes of the mouse brain hippocampus, cortex and cerebellum
Synaptic transmission forms the main mode of signaling and information integration in the nervous system. Here, we identified and quantified proteins from three brain regions and five biochemical synapse sub-fractions. We identified around 4500 proteins in total, of which about 2000 proteins each we...
ORGANISM(S): Mus musculus (Mouse) 
2017-09-25 | PXD005634 | Pride
Post synaptic density Synapse Proteomics Correlation profiling 
ProteomicsMS-DAP platform for label-free proteomics uncovers optimal workflows in benchmark datasets and increased sensitivity in analysis of Alzheimer's biomarker data
In the rapidly moving proteomics field, a diverse patchwork of algorithms for data normalization and differential expression analysis is used by the community. We generated an all-inclusive mass spectrometry downstream analysis pipeline (MS-DAP) that integrates many algorithms for normalization and ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2023-03-10 | PXD036134 | Pride
Alzheimer’s disease Proteomics Software Benchmarking Bioinformatics 
ProteomicsHuman brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia
Understanding the pathophysiological substrates of schizophrenia is a major challenge for current neuropsychiatric research. As part of a set of multi-omics experiments, we performed an extensive case-control proteomics study on 192 post-mortem tissue sections from prefrontal cortex from 96 individu...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD058441 | Pride
UnknownMapping genomic loci implicates genes and synaptic biology in schizophrenia.
Not available
S-EPMC9392466 | biostudies-literature
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
Sort   by:  
 Page size