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ProteomicsLipid droplet-targeted APEX proteome
Lipid droplet (LD) function is regulated by a complement of integral and peripheral proteins that associate with the LD phospholipid monolayer. Defining the composition of the LD proteome has remained a challenge due to the presence of contaminating proteins in LD-enriched buoyant fractions. To over...
ORGANISM(S): Homo sapiens (Human) 
2017-12-22 | PXD007695 | Pride
Lipid droplet Apex Erad 
ProteomicsMammals produce cyclo-octasulfur to suppress lipid peroxidation and ferroptosis
This dataset contains LC-ESI-Q-TOF tandem mass spectrometry data acquired to examine the protein composition of lipid droplets isolated from differentiated mouse 3T3-L1 adipocytes. Lipid droplet-associated proteins were delipidated, reduced, alkylated, and digested with trypsin before analysis by da...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-26 | PXD080540 | Pride
Sulfide oxidoreductase Perilipin Lc-q-tof-ms/ms Lipid droplet proteome Caveolin-1 Dda Enos 
ProteomicsAPOE genotype shapes lipid droplet composition and dynamics in human astrocytes
Lipid droplets are dynamic organelles involved in cellular functions ranging from lipid storage regulation to immune modulation. The proteins that localize to the lipid droplet membrane play a critical role in determining these functions. Recent research has highlighted the involvement of glial lipi...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD067161 | Pride
Lipid proteomics Apoe  astrocytes 
TranscriptomicsIntegrated omics studies delineate the formation and dynamics of lipid droplets in Rhodococcus opacus PD630 for biofuel feedstock
Purpose: To delineate mechanisms underlying lipid storage in LDs, we compared the transcriptomes of cells cultivated under three lipid-accumulating conditions. Methods: PD630 mRNA profiles of 3 different conditions (normal condition and LDs acculation conditions) were generated by deep sequencing, u...
ORGANISM(S): Rhodococcus opacus 
2013-11-04 | E-GEOD-42381 | biostudies-arrayexpress
ProteomicsComparative proteomic study on liver lipid droplets and mitochondria from mouse housed in different temperatures
Laboratory mice are standardly housed around 23ºC, setting them under chronic cold stress. Metabolic changes of liver in mice housed under thermoneutral, standard and cold temperatures remain unknown. Here we isolated lipid droplets and mitochondria from their livers for comparative proteomic study ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-07-17 | MSV000084105 | MassIVE
ProteomicsLipid-induced Caveolin1-Lipid droplet trafficking is needed for lipid droplet growth
Caveolae are 50-100 nm sized plasma membrane invaginations that were previously related to cellular lipid uptake and lipid accumulation. Several caveolin1 and cavin1 mutations are associated to human lipodystrophy. However, currently is not understood how caveolae facilitate the lipid uptake, how in...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-23 | PXD069518 | Pride
Lipid Droplet Caveolin1 Dia Trafficking 
ProteomicsMouse Hepatic Lipid Droplet Proteome under Fasting and Re-Feeding
One of the key functions of the mammalian liver is lipid metabolism. During fasting, lipid storage in the liver increases in order to reserve and provide energy for cellular functions. Upon re-feeding, this reserve of lipids is rapidly depleted; this change is visible, as the organelles responsible ...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-25 | PXD005977 | Pride
Lipid droplet proteome Mouse Lipid metabolism Liver lds Lipid droplets Lc-ms/ms 
ProteomicsLipid droplet proteomics of THP1 macrophages infected with Mycobacterium tuberculosis
Growing evidence suggests the importance of lipid metabolism in pathogenesis of tuberculosis. Neutral lipids form the majority of lipids in caseous granulomas characteristic of tuberculosis. Macrophage lipid droplets form the store house of these lipids, yet infection induced changes in the proteome...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD008950 | Pride
Macrophage Tuberculosis Subcellular proteomics Lipid droplets Lysosomes Orbitrap fusion 
ProteomicsLabel free comparative proteome analysis of Arabidopsis lipid droplets from 6 week old leaves
Lipid droplets from 6 week old Arabidopsis leaves were purified on sucrose gradient. The abundance of the proteins in the lipid droplet fraction was established by label free and compared to soluble, membrane and plastoglobule fractions, and total leaf extract in order to identify the proteins speci...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-06-19 | PXD006113 | Pride
Oil bodies Arabidopsis Lipid droplet Leaf Label free 
ProteomicsThe fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics
Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic dysfunction-associated steatotic liver disease (MASLD), is a progressive metabolic disorder that begins with aberrant triglyceride accumulation in the liver and can lead to cirrhosis and cancer. A common variant in the gene PNPLA3...
ORGANISM(S): Homo sapiens (Human) 
2024-04-10 | PXD046335 | Pride
Endosome Masld Golgi Liver disease Pnpla3 Lipid droplet Nafld 
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