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ProteomicsHLA-B40-peptidome - Increased Diversity of the HLA-B40 Ligandome by the Presentation of Peptides Phosphorylated at Their Main Anchor Residue
HLA class I molecules bind peptides derived from the intracellular degradation of endogenous proteins and present them to cytotoxic T lymphocytes, allowing the immune system to detect transformed or virally infected cells. It is known that endogenous HLA class I associated peptides may harbor posttr...
ORGANISM(S): Homo sapiens (Human) 
2014-02-03 | PXD000450 | Pride
Phosphopeptidome Hla Peptidome Mhc Hla-b40 
ProteomicsB27 inmunopeptidome in vaccinica infected cells
Identification of natural human leukocyte antigen (HLA) ligandome is a key element to understand the cellular immune responses. Advanced high throughput mass spectrometry analyses identify a relevant, but not complete, fraction of the many tens of thousands of self-peptides generated by the antigen ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-22 | PXD027859 | Pride
Hla-b*27 Vaccinica Hla Immunopeptidomics 
ProteomicsHLA-DRB1*15:01 and HLA-DRB5*01:01 peptidomes
HLA-DR15 is a haplotype associated with multiple sclerosis. It contains the two DRB* genes DRB1*1501 (DR2b) and DRB5*0101 (DR2a). The reported anchor motif of the corresponding HLA-DR molecules was determined years ago based on a small number of peptide ligands and binding assays. DR2a could display...
ORGANISM(S): Homo sapiens (Human) 
2017-10-10 | PXD006534 | Pride
Hla-dr15 Multiple sclerosis Drb5*0101 Drb1*1501 Hla-ii Peptidome 
ProteomicsCross-linking Analysis (HSP70-HSP90-CHIP)
Some molecular chaperones are involved not only in assisting the folding of proteins but also, given appropriate conditions, in their degradation. This is the case of Hsp70 and Hsp90, which in concert with the cochaperone CHIP –an E3 ligase–, direct their bound substrate to degradation through ubiqu...
ORGANISM(S): Homo sapiens (Human) 
2019-03-06 | PXD009777 | Pride
Hsp90 Dtssp Hsp70 Chip 
ProteomicsHLA-I peptidomes and phosphopeptidomes (B*40, B*27, B*07, B*39)
As aberrant phosphorylation is a hallmark of tumor cells, the display of tumor-specific phosphopeptides by Human Leukocyte Antigen (HLA) class I molecules can be exploited in the treatment of cancer by T-cell-based immunotherapy. Yet, the characterization and prediction of HLA-I phospholigands is ch...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD005084 | Pride
Phosphopeptidome Mhc Peptidome Hla 
ProteomicsXL-MS analysis of human tyrosine hydroxylase
Tyrosine hydroxylase (TH) is a highly regulated enzyme that catalyses the rate-limiting step in the biosynthesis of dopamine (DA) and other catecholamines. Mutations and dysfunction in this enzyme lead to DA deficiency and parkinsonisms of different severity. An understanding of TH deficiency at the...
ORGANISM(S): Homo sapiens (Human) 
2021-12-22 | PXD024519 | Pride
Xl-ms Dopamine Tyrosine hydroxylase Bs3 
ProteomicsProteomic profiling of human mesenchymal stem cells derived from umbilical cord or adipose tissue
We performed a proteomic profiling of human mesenchymal stem cells (hMSCs) derived from adipose tissue or umbilical cord.
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009893 | Pride
Adipose tissue Human mesenchymal stem cells Hmscs Umbilical cord 
ProteomicsMHC Peptidomics: HLA-B*27 vs Mamu-B*08
Indian rhesus macaques are arguably the most reliable animal models in AIDS research. In this species the MHC class I allele Mamu-B*08, among others, is associated with elite control of SIV replication. A similar scenario is observed in humans where the expression of HLA-B*27 or HLA-B*57 has been li...
ORGANISM(S): Homo sapiens (Human) 
2016-10-07 | PXD004964 | Pride
Peptides Hla-b*27 Mhc Hiv Peptidomics Mamu-b*08 Lc-ms/ms Siv 
UnknownPhase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/ CDKN2A.
Not available
S-EPMC10598203 | biostudies-literature
ProteomicsChr16-HPP. Shotgun Analysis improvement. JPR HPP Special issue 2013. Jurkat Cell line.
The Chromosome 16 Consortium is integrated in the Human Proteome Project that aims to develop an entire map of the proteins encoded by the human genome following a gene-centric strategy (C-HPP) to make progress in the understanding of human biology in health and disease (B/D-HPP). To do this study f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-12 | MSV000083966 | MassIVE
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