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ProteomicsIdentification of HJURP binding determinants on the Mis18 complex using photo-cross-linking and mass spectrometry
In the early G1 phase of the cell cycle, human HJURP is recruited to centromeres by the Mis18 complex, which consists of Mis18α, Mis18β and M18BP1. This interaction of HJURP with the Mis18 complex is essential for CENP-A deposition and the preservation of centromere identity. To identify the binding...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD013339 | Pride
Photo-cross-linking Q-exactive Abk Human Kinetochore Centromere Protein complex Bpa Stavrox 
ProteomicsOverlap of NatA and IAP substrates implicates N-terminal acetyltion in protein stabilization
SMAC/DIABLO and HTRA2 are mitochondrial proteins whose N-termina sequences, known as inhibitor of apoptosis binding motifs (IBMs), bind and activate ubiquitin ligases knwon as inhibitor of apoptosis proteins (IAPs), unleashing a cell´s poteintial.IBMs comprise a 4-residue, loose consensus sequence, ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021815 | Pride
N-terminal acetylation Birc3 Birc2 Natb N-terminomics Nata Apoptosis Xiap N-degron 
ProteomicsInteraction mapping of human condensin I and condensin II complexes using DSBU-cross-linking and mass spectrometry
Human condensin I and condensin II complexes play essential roles in chromatin condensation during the cell division process. Both complexes use ATP as the energy source to pack extended chromatin into the short form of chromosome. In order to understand the mechanism of their function, we performed...
ORGANISM(S): Homo sapiens (Human) 
2020-05-25 | PXD017531 | Pride
Condensin Dsbu Q-exactive Cross-linking Human Protein complex Xl-ms Chromatin Chromosome 
ProteomicsCondensin II Activation by the centromeric protein M18BP1
Condensin I and condensin II promote drastic spatial compaction (condensation) of the genome upon mitotic entry. Condensin I binds chromatin only after dissolution of the nuclear envelope in prophase. Conversely, condensin II is nuclear throughout the cell cycle and initiates chromosome condensation...
ORGANISM(S): Homo sapiens (Human) 
2025-07-09 | PXD051886 | Pride
Sda Sulfo-sda Condensin Cryo-em Xl-ms M18bp1 Crosslinking 
UnknownGender-Disparities in Adults with Type 1 Diabetes: More Than a Quality of Care Issue. A Cross-Sectional Observational Study from the AMD Annals Initiative.
Not available
S-EPMC5047461 | biostudies-literature
ProteomicsChemical cross-linking of the Spindly-RZZ complex followed by mass spectrometry
Kinetochores are macromolecular assemblies that connect chromosomes to spindle microtubules during mitosis. The metazoan-specific ≈800 kilodalton ROD-Zwilch-ZW10 (RZZ) complex builds a fibrous corona that assembles on mitotic kinetochores prior to microtubule attachment to promote chromosome alignme...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD005287 | Pride
Human  spindly-rzz complex  spindly  rod  zwilch  zw10  cx-ms  orbitrap 
UnknownM18BP1 valency and a distributed interaction footprint determine epigenetic centromere specification in humans
Not available
S-SCDT-10_1038-S44318-026-00698-Z | biostudies-other
UnknownRZZ-Spindly and CENP-E form an integrated platform to recruit Dynein to the kinetochore corona
Not available
S-SCDT-10_15252-EMBJ_2023114838 | biostudies-other
UnknownStable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding
Not available
S-SCDT-10_15252-EMBJ_2022112504 | biostudies-other
UnknownMolecular requirements for PLK1 activation by T-loop phosphorylation
Not available
S-SCDT-10_1038-S44318-025-00681-0 | biostudies-other
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