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TranscriptomicsThe effect of MPO inhibitor on the gene expression profiles in HL-60 cell lines exposed to 1, 2, 4,-benzenetriol
To reveal the gene expression profile changes after exposure to BT, one of benzene metabolites, with or without ABAH, a myeloperoxidase (MPO) inhibitor, and to elucidate how MPO is involved in myelotoxicity of BT, we performed microarray analysis. HL-60 cells suspended in RPMI 1640 containing with 1...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-50805 | biostudies-arrayexpress
ProteomicsComprehensive quantification of modifications of human and mouse myeloperoxidase by LC-MSMS
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic and refractory disease, characterized by necrotizing small to medium vessel vasculitides. AAV constitutes three distinct disorders: microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA) (formerly k...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-04-21 | PXD050920 | Pride
Human Lc-msms Oxidative modification Mouse Myeloperoxidase 
ProteomicsThe Bimodal Sugar Code of Neutrophil Myeloperoxidase
Myeloperoxidase (MPO), an important diprotomeric glycoprotein in neutrophil-mediated immunity, produces microbicidal hypohalous acids, but the underpinning glycobiology remains elusive. Deep characterisation of neutrophil-derived MPO (nMPO) using advanced mass spectrometry demonstrated that under-pr...
ORGANISM(S): Homo sapiens (Human) 
2021-03-07 | PXD021131 | Pride
Biosynthesis Granulopoiesis Degranulation Neutrophil Activity : myeloperoxidase N-glycosylation N-acetyl-β-d-glucosamine Ceruloplasmin Granule Inhibition 
ProteomicsLabel-free mass spectrometry analysis of laminin with induced oxidations and chlorination’s facilitated with hypochlorous acid and myeloperoxidase treatments.
Basement membranes are specialized extracellular matrices that underlie arterial wall endothelial cells, with laminin being a key structural and biologically-active component. Hypochlorous acid (HOCl), a potent oxidizing and chlorinating agent, is formed in vivo at sites of inflammation, via the enz...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-05 | PXD022056 | Pride
Ecm Lc-ms/ms Oxidation Extracellular matrix proteins Inflammation. Chlorination Laminin 
ProteomicsMyeloperoxidase is a Critical Mediator of Anthracycline-induced Cardiomyopathy
The anthracycline doxorubicin is a commonly used chemotherapeutic drug that induces cardiomyopathy in almost 10% of patients. The aim of this study was to examine the role of the leukocyte-derived enzyme Myeloperoxidase (MPO) in pathogenesis of anthracycline-induced Cardiomyopathy (AICM). We perform...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-30 | PXD037524 | Pride
Cardiotoxicity Polymorphonuclear neutrophils Aicm Mpo Doxorubicin 
GenomicsMyeloperoxidase gene deletion in dextran sodium sulfate-induced colitis
Myeloperoxidase gene deletion in dextran sodium sulfate-induced colitis
PRJEB66447 | ENA
UnknownThe Roles of Neutrophil-Derived Myeloperoxidase (MPO) in Diseases: The New Progress.
Not available
S-EPMC10812636 | biostudies-literature
UnknownSNP rs2243828 in MPO associated with myeloperoxidase level and atrial fibrillation risk in Chinese Han population.
Not available
S-EPMC7520285 | biostudies-literature
TranscriptomicsTranscription profiling of human HOCL airway epithelial cells treated wih HOCl to investigate dose dependent toxicity
In inflammatory diseases of the airway, a high level (estimated to be as high as 8 mM) of HOCl can be generated through a reaction catalyzed by the leukocyte granule enzyme myeloperoxidase (MPO). HOCl, a potent oxidative agent, causes extensive tissue injury through its reaction with various cellula...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-11630 | biostudies-arrayexpress
TranscriptomicsREG3γ-deficient mice have altered mucus distribution and increased mucosal inflammatory responses to the microbiota and enteric pathogens in the ileum
Objective: Reg3g has been proposed to have a protective role against infection due to its bactericidal effect on Gram-positive bacteria, but evidence from in vivo studies is lacking. Therefore we generated a Reg3g-/- mouse, to determine its role in intestinal homeostasis and protection against exper...
ORGANISM(S): Mus musculus 
2014-06-06 | E-GEOD-44409 | biostudies-arrayexpress
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