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ProteomicsDiscovery of biomarkers for amyotrophic lateral sclerosis from human cerebrospinal fluid using mass spectrometry-based proteomics
Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative diseases characterized by the relentless loss of upper and lower motor neurons, eventually leading to death. Critical to the mission of developing effective therapies for ALS is the discovery of biomarkers that can illuminate mecha...
ORGANISM(S): Homo sapiens (Human) 
2023-05-22 | PXD038846 | Pride
Cerebrospinal fluid Proteomics Mass spectrometry Amyotrophic lateral sclerosis And biomarker 
ProteomicsIntracellular Energy Controls Dynamics of Stress-induced Ribonucleoprotein Granules Implicated in ALS/FTD
Energy metabolism and membraneless organelles have been implicated in human diseases including neurodegeneration. How energy deficiency regulates ribonucleoprotein particles such as stress granules (SGs) is still unclear. Here we identified a unique type of granules formed under energy deficiency an...
ORGANISM(S): Homo sapiens (Human) 
2022-10-15 | PXD035747 | Pride
Stress granule  energy metabolism  als/ftd  protein homeostasis 
ProteomicsQuantitative serum proteomic analysis for potential biomarkers in post-COVID-19 onset Postural Orthostatic Tachycardia Syndrome (PC-POTS) patients
Postural orthostatic tachycardia syndrome (POTS) is a chronic neurological disorder of the autonomic nervous system (ANS) that is characterized by an excessive increase in heart rate upon orthostatic challenge. The symptoms of POTS are often debilitating, and it primarily affects young females. Even...
ORGANISM(S): Homo sapiens (Human) 
2025-05-08 | PXD052725 | Pride
Post-acute sequelae of covid-19 Post-covid-19 syndrome Mass spectrometry Postural orthostatic tachycardia syndrome Long covid syndrome Tandem mass tag Serum proteomics Biomarker 
ProteomicsiCAB: Development of an in situ cell-type specific proteome analysis method using antibody-mediated biotinylation
Since proteins are essential molecules exerting cellular functions, decoding proteome changes is the key to understanding the normal physiology and pathogenesis mechanism of various diseases. However, conventional proteomic studies are often conducted on tissue lumps, in which multiple cell types ar...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD046362 | Pride
Neuron Astrocytes Microglia. Brain Mass spectrometry Cell-type-specific proteome analysis Immunohistochemistry Biotin-tyramide 
ProteomicsBiomarkers discovery for progressive supranuclear palsy from the human cerebrospinal fluid using mass spectrometry-based proteomics
Progressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder. This study using CSF samples of PSP patients is a follow-up study to discover biomarkers related to the previous PSP brain results. This study is the first-ever attempt at an in-depth global proteomic study using more...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD041417 | Pride
Cerebrospinal fluid Proteomics Progressive supranuclear palsy Mass spectrometry Biomarkers 
ProteomicsMass spectrometry-based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the disease
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain. Despite decades of studies, the precise pathogenic mechanism of PD is still elusive. An unbiased proteomic analysis of PD pati...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD037684 | Pride
Proteomics Parkinson's disease Mass spectrometry Mitoribosomes Human brain tissue Substantia nigra 
ProteomicsMyeloid lineage C3 induces reactive gliosis and neuronal stress during CNS inflammation
Complement component C3 mediates pathology in several CNS neurodegenerative diseases, but the cellular and molecular mechanisms leading to neuronal injury remain unclear. We examined how C3 deletion affects glial profiles and anterior visual pathway pathology in an animal model of neuroinflammation,...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-17 | PXD054869 | Pride
Neuroinflammation Neuronal injury Eae Multiple sclerosis Complement component 3 Microglia Optic neuritis Retina Oct 
ProteomicsDevelopment of a method for the quantification of tyrosine 39 phosphorylated alpha-synuclein in human cerebrospinal fluid
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder caused by dopaminergic neuronal deaths. For a proper treatment of PD, biomarkers that would enable us to monitor disease progression or responses to a disease-modifying agent, or that can be used as a presymptomatic mar...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012202 | Pride
Parkinson's disease Parallel reaction monitoring Enrichment Alpha-synuclein Phosphotyrosine 
ProteomicsDiscovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysis
Proteomic biomarkers for Parkinsons disease (PD) are critical for identifying new targets for disease modifying therapies and expanding our understanding of the disease pathophysiology.
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD055996 | Pride
Proteomics Parkinsons disease Csf Biomarker 
ProteomicsMass spectrometry-based proteomics analysis of human globus pallidus from progressive supranuclear palsy patients discovers multiple disease pathways
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder clinically characterized by progressive postural instability, supranuclear gaze palsy, parkinsonism, and cognitive decline caused by degeneration in specific areas of the brain including globus pallidus (GP), substantia nigra, and ...
ORGANISM(S): Homo sapiens (Human) 
2022-12-08 | PXD031648 | Pride
Globus pallidus Psp Proteomics Progressive supranuclear palsy Mass spectrometry Human brain tissue 
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