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UnknownQing-Kai-Ling oral liquid alleviates non-alcoholic fatty liver disease via remodeling gut microbiota and activating AMPK/ACC1 axis.
Not available
S-EPMC12536533 | biostudies-literature
UnknownQing-Kai-Ling oral liquid alleviated pneumonia via regulation of intestinal flora and metabolites in rats.
Not available
S-EPMC10288885 | biostudies-literature
ProteomicsProteogenomic Integration Reveals Therapeutic Targets in Breast Cancer Xenografts
Huang K, Li S, Mertins P, Cao S, Gunawardena HP, Ruggles KV, et al., (2017) Nature Communications | 8:14864 | DOI: 10.1038/ncomms14864 | http://www.nature.com/articles/ncomms14864

Recent advances in mass spectrometry (MS) hav...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-28 | MSV000084249 | MassIVE
ProteomicsSILAC based quantitative 3-hydroxybutyromics of HBO1-WT and HBO1-KO HeLa cells
Ketogenesis derived BHB facilitates 3-hydroxybutyrylation on lysine linking metabolism with epigenetic regulation. Herein, we found HBO1 served as 3-hydroxybutyryltransferase preferentially catalyzing lysine 9 of histone H3 (H3K9bhb). Moreover, total 1171 Kbhb sites on 582 proteins were identified. ...
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051668 | Pride
Human Cervical cancer Kbhb Hbo1 Lc-ms/ms 
ProteomicsLabel-free DDA proteome for identifying the interacting proteins of HBO1
HBO1 is an important transcriptional activator for organism to respond to natural stress. Here, we performed IP-MS for determining the interacting proteins of HBO1 under stimulation of BHB.
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051692 | Pride
Human Label-free Ip-ms Hbo1 
Proteomicslabel free quantitative proteomics for determining the biological characterastic of eukaryocyte with or without BHB.
BHB is the major part of ketone body in plasm that is usually at low concentration. Dramatical increase of BHB is due to prologation fasting or diabetes. In addation to enegetic carrier for metabolic reprogramming, BHB is also involved in epigenetic regulation. Here, we illustrats the BHB-induced pr...
ORGANISM(S): Homo sapiens (Human) 
2025-07-04 | PXD051685 | Pride
Human Bhb Label-free Lc-ms/ms 
ProteomicsSILAC experiment quantifying the proteomics of WT and HBO1-KO HeLa
Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in multiple biological processes. We report that HBO1 functions as a lysine lactyltransferase to regulate transcription. Quantitative proteomic analysis further revealsed 95 endogenous Kla sites targeted by HBO1, with...
ORGANISM(S): Homo sapiens (Human) 
2024-04-13 | PXD051415 | Pride
Hela Lc-msms Hbo1 Kla 
ProteomicsInterorgan communication in the neurogenic heterotopic ossification: focusing on the role of brain-derived extracellular vesicles
Brain-derived extracellular vesicles participate in inter-organ communication after traumatic brain injury by transporting pathogens to initiate secondary injury. Inflammasome related proteins encapsulated in brain-derived extracellular vesicles are capable of crossing the blood-brain barrier to rea...
ORGANISM(S): Rattus Rattus 
2023-11-02 | PXD046626 |
TranscriptomicsDeep RNA Sequencing Reveals Dynamic Regulation of Myocardial Noncoding RNA in Failing Human Heart and Remodeling with Mechanical Circulatory Support
Complete transcriptome profiling in human failing and non-failing control hearts using next-gen sequencing Poly-A selected RNA and small RNA sequencing carried out in 5 groups of samples: NF, ICM, NICM, ICM+LVAD, NICM+LVAD
ORGANISM(S): Homo sapiens 
2014-02-10 | E-GEOD-46224 | biostudies-arrayexpress
ProteomicsA histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation
The RDM15 genomic sequence was fused in frame to the 3xFLAG tag and 3xMYC tag, and the fused sequences were inserted into the pCambia1305 backbone and were transformed into Arabidopsis plants, respectively. A 5-g quantity of flower tissue was harvested from transgenic plants and ground in liquid nit...
ORGANISM(S): Arabidopsis Thaliana 
2021-04-01 | PXD025147 |
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