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ProteomicsTargeting ERAP enhances anti-tumor immunity by disrupting the NKG2A/HLA-E inhibitory checkpoint
New targets that enhance anti-tumor immunity must be identified to improve the efficacy of cancer immunotherapy. Here we show that loss of endoplasmic reticulum aminopeptidase (ERAP) family proteins improves anti-tumor immunity and synergizes with immune checkpoint blockade. Mechanistically, we show...
ORGANISM(S): Homo sapiens (Human) 
2024-11-21 | PXD052031 | Pride
Human Hla-e Orbitrap Immunotherapy 
ProteomicsReversal of protein aging by enzymatic deglycation
A hallmark of mammalian aging is the accumulation of irreversible molecular damage on proteins of the extracellular matrix. The advanced glycation endproduct Nε-carboxymethyl-lysine (CML) is abundant in aging human tissues, where it generates neoepitopes leading to inflammatory signaling. Here we de...
ORGANISM(S): Bos taurus (Bovine) 
2026-07-16 | PXD070124 | Pride
Lc-msms Cml Glycation Bsa 
ProteomicsMorphological and genetic screens reveal mechanisms of BiDAC-induced plasma membrane protein degradation
The discovery of bifunctional degradation activating compounds (BiDACs) has led to the development of a new class of drugs that promote the clearance of their protein targets. BiDAC-induced ubiquitination is generally believed to direct cytosolic and nuclear proteins to proteolytic destruction by pr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-11 | PXD057365 | Pride
Human Lc-msms Ap-ms Q exactive 
ProteomicsCharacterizing T-cell immunopeptidomes
Imunopeptidomes promise novel surface markers as ideal targets for immunotherapies, but their characterization by mass spectrometry (MS) remains challenging. Until recently, cell numbers exceeding 1.0xE9 were needed for reasonably deep immunopeptidome surveys of at least 1,000 HLA ligands. Such limi...
ORGANISM(S): Homo sapiens (Human) 
2018-03-08 | PXD007860 | Pride
Human Antigen presentation T cell Mhc Orbitrap 
ProteomicsTuning DO:DM ratios modulates HLA class II immunopeptidomes
Major Histocompatibility Complex Class II antigen presentation underlies a wide range of immune responses in health and disease. Although peptide ligand binding affinity has been the major focus for explaining and predicting class II antigens, we know that the levels and activities of accessory mol...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD024392 | Pride
Hla-ii Mhc Dm Antigen presentation Do Orbitrap 
ProteomicsImpairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
Protein aggregation increases during aging and is a pathological hallmark of many age-related diseases. Protein homeostasis (proteostasis) depends on a core network of factors directly influencing protein production, folding, trafficking, and degradation. Cellular proteostasis also depends on the ov...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD054648 | Pride
Human Tmt Lysosomes Proteostasis Orbitrap 
ProteomicsB cell Lymphomas present Immunoglobulin Neoantigens
Immunoglobulin gene rearrangement and somatic hypermutation have the potential to create neoantigens in non-Hodgkin B cell lymphoma. However, the presentation of these putative immunoglobulin neoantigens by B cell lymphomas has not been proven. We used MHC immunoprecipitation followed by liquid chr...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010808 | Pride
Lymphoma Neoantigens Mhc Orbitrap 
ProteomicsAn integrated genomic, proteomic and immunopeptidomic approach to discover treatment-induced neoantigens
All nucleated mammalian cells express major histocompatibility complex (MHC) proteins that present peptides on cell surfaces for immune surveillance. These MHC-presented peptides (pMHC) can convey non-self antigens derived from pathogens or mutations to amount T-cell responses. Alterations in tumor-...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020750 | Pride
Human Mhc Interferon gamma Antigen presentation Orbitrap 
ProteomicsAML HLA Ligandome reveals mutated NPM1 as a recurrent neoantigen
Somatic mutations in cancer are a potential source of cancer specific neoantigens. Acute myeloid leukemia (AML) has common recurrent mutations shared between patients in addition to private mutations specific to individuals. We hypothesized that neoantigens derived from recurrent shared mutations wo...
ORGANISM(S): Homo sapiens (Human) 
2019-07-17 | PXD012083 | Pride
Homo sapiens Hla Acute myeloid leukemia Neoantigen 
ProteomicsExercise plasma dampens brain inflammation via clusterin and boosts memory
Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects....
ORGANISM(S): Mus musculus (Mouse) 
2021-12-22 | PXD022262 | Pride
Lc-msms Mouse Plasma 
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