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ProteomicsTMEM16K is an interorganelle regulator of endosomal sorting.
Using proximity biotinylation proteomics based on TMEM16K/Ano10 (an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia) BioID chimeras, we identify endosomal transport as a major functional cluster of interacting proteins.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-05-30 | PXD018990 | Pride
Bioid Endosomal sorting Tmem16k 
ProteomicsProteomic analysis of vitreous in WT and CD11b KO mice.
Our data support that following optic nerve crush injury, ocular infiltration of immune cells causes damage to the retinal vasculature and compromises the integrity of the blood-retina barrier (BRB). Functional ablation of integrin alphaM (CD11b) attenuates immune cell trafficking, protects the BRB,...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-05 | PXD045885 | Pride
Mouse Tmt Vitreous Itgam. Cd11b Label free 
ProteomicsThe GAR Domain Determines Subcellular Localization of the Growth Controlling RNA Binding Protein Nucleolin
In this project we aimed to identify the spectrum of protein binders of nucleolin’s glycine arginine reach (GAR) domain. We did so by designing a 15 amino acid peptide derived from the GAR domain sequence, which includes 3 arginine-glycine-glycine (RGG) repeats and we call "R3". We conducted affinit...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-23 | PXD020804 | Pride
Kinesin Glycine-arginine rich domain Rna binding protein localization Axonal transport Plasma membrane localization Nucleolin 
ProteomicsPlxnA2 interactome in primary hippocampal murine neurons
Proper assembly of complex neural circuits requires the coordinated action of a limited set of axon guidance molecules, including plexins. To probe the extracellular vicinity of PlxnA2 in primary hippocampal neurons, we used in this work antibody directed proximity biotinylation and identified cand...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-16 | PXD060323 | Pride
Biotinylation by antibody recognition Bar. Proximity labelling Plxna2 
ProteomicsComposition and origin of lung fluid proteome in premature infants and relationship to respiratory outcome
We performed global proteomics of premature infant tracheal aspirate (TA) and plasma to determine the composition and source of lung fluid proteins and to identify potential biomarkers of respiratory outcome
ORGANISM(S): Homo sapiens (Human) 
2020-11-23 | PXD021966 | Pride
Tracheal aspirate Plasma Lung disease Premature infants 
ProteomicsThe Perijunctional Zone Is a Molecularly Distinct Muscle Subdomain Altered in Duchenne Muscular Dystrophy
The neuromuscular junction (NMJ) is a well-established model for synapse development, structure, and function. Surrounding the NMJ is a narrow perijunctional zone (PJZ), enriched in muscle-specific voltage-gated sodium channels that prevent synaptic fatigue. Despite this role, the PJZ remains poorly...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-27 | PXD067080 | Pride
Muscle proteomics Perijunctional zone Perilipin 4 Turboid Proximity labelling Duchenne muscular dystrophy Neuromuscular junction 
ProteomicsSynaptic vesicles that store monoamines and glutamate differ in protein composition
Neuromodulators such as monoamines assure essential brain functions but relatively little is known about their mechanism of release. While recent work has advanced our knowledge of active zone architecture in dopamine axons, release machinery within the synaptic vesicle (SV) remains poorly understoo...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD073685 | Pride
Synaptic vesicles Tmt Vmat2 Dopamine release Vglut2 
ProteomicsPhospho-proteome profiling in human induced pluripotent stem cells and derived human neurons reveals targets of TBK1 in ALS/FTD-1 associated autophagy networks
TBK1 (TANK-binding kinase 1) is a ubiquitously expressed IKK-related kinase implicated in diverse cellular processes, including interferon signaling, apoptosis, and autophagy. Loss-of-function variants in TBK1 are strongly associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dement...
ORGANISM(S): Homo sapiens (Human) 
2025-09-11 | PXD068150 | Pride
Autophagy Neurons Tnk1 Phosphorylation 
ProteomicsQuantitative analysis of the mouse brain phosphoproteome in mTORC2 KO mutants
Here we are using unbiased phosphoproteomics analyses to try to identify selective targets of mTORC2 in mouse brain.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-20 | PXD045878 | Pride
Mouse Tmt Mtorc2 Phosphorylation 
ProteomicsProximity labelling and LCMSMS analysis of spliceosome complexes using SUGP1-miniTurbo
The purpose of the project is to identify proteins binding differentially to the human specific spliceosomal protein SUGP1 in the context of point mutations to its G-patch domain. SUGP1 wt and mutant (G603N or L570E) C-terminally tagged with mini-Turbo-NLS was overexpressed for 48 h in HEK293T cell...
ORGANISM(S): Homo sapiens (Human) 
2023-10-05 | PXD038067 | Pride
Spliceosome Sugp1 Proximity labeling Miniturbo Bioid 
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