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ProteomicsIdentification of HJURP binding determinants on the Mis18 complex using photo-cross-linking and mass spectrometry
In the early G1 phase of the cell cycle, human HJURP is recruited to centromeres by the Mis18 complex, which consists of Mis18α, Mis18β and M18BP1. This interaction of HJURP with the Mis18 complex is essential for CENP-A deposition and the preservation of centromere identity. To identify the binding...
ORGANISM(S): Homo sapiens (Human) 
2019-08-01 | PXD013339 | Pride
Photo-cross-linking Q-exactive Abk Human Kinetochore Centromere Protein complex Bpa Stavrox 
Unknown3,4-Seco-Isopimarane Diterpenes from the Twigs and Leaves of Isodon Flavidus.
Not available
S-EPMC9143206 | biostudies-literature
UnknownBioactive isopimarane and 3,4-seco isopimarane diterpenoids from Isodon amethystoides.
Not available
S-EPMC9661758 | biostudies-literature
ProteomicsInteraction mapping of human condensin I and condensin II complexes using DSBU-cross-linking and mass spectrometry
Human condensin I and condensin II complexes play essential roles in chromatin condensation during the cell division process. Both complexes use ATP as the energy source to pack extended chromatin into the short form of chromosome. In order to understand the mechanism of their function, we performed...
ORGANISM(S): Homo sapiens (Human) 
2020-05-25 | PXD017531 | Pride
Condensin Dsbu Q-exactive Cross-linking Human Protein complex Xl-ms Chromatin Chromosome 
ProteomicsCross-linking mass spectrometry analyses of three different kinetochore protein complexes (KMN, NDC80C, MIS12C) using an MS-cleavable cross-linker, BuUrBu (DSBU)
In order to develop a simplified cross-linking mass spectrometry protocol, we applied one-step size-exclusion chromatography (SEC) for peptide purification after proteolysis with Lys-C and trypsin. Three benchmark protein complexes (KMN, NDC80C, MIS12C) from human kinetochore were cross-linked with ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-01 | PXD010070 | Pride
Dsbu Q-exactive Cross-linking ms Buurbu Merox Human Kinetochore Protein complex Ms-cleavable cross-linker 
ProteomicsIdentification the proteins interacted with ILF2 in human keratinocytes
By profiling lncRNA expression changes during human skin wound healing and screening lncRNA functions, we identified SNHG26 as a pivotal regulator in keratinocyte progenitors underpinning this phase transition. we performed RNA pull-down assay in human keratinocyte progenitors and found SNHG26 inter...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD055235 | Pride
Keratinocyte Ilf2 
ProteomicsIdentification the proteins interacted with SNHG26 in human keratinocytes
The cell transition from an inflammatory phase to a subsequent proliferative phase is crucial for wound healing, yet the driving mechanism remains unclear. By profiling lncRNA expression changes during human skin wound healing and screening lncRNA functions, we identified SNHG26 as a pivotal regulat...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD055231 | Pride
Snhg26 Keratinocyte 
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