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ProteomicsMultiple classes of antigen contribute to the antigenic landscape of mesothelioma
Mesothelioma is an incurable, asbestos-exposure related cancer that typically affects the lining or pleura of the lungs. Symptoms typically develop many decades after initial exposure to asbestos, leaving an enduring legacy of disease. Vaccine-induced augmentation of immune responses unleashed durin...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054498 | Pride
Mass spectrometry Hla class i Mesothelioma Asbestos related cancer Immunopeptidomics Lung cancer 
ProteomicsImmunopeptidome of an acute myeloid leukemia cell line THP1
We report the use of complementary peptide antigen enrichment and comprehensive mass spectrometric acquisition strategies to provide in-depth immunopeptidome data for AML cell line THP1
ORGANISM(S): Homo sapiens (Human) 
2020-05-13 | PXD015039 | Pride
Aml Cancer Hla class i Ptm Immunopeptidome 
ProteomicsThe HLA peptide repertoire of SaOS-2 cell line transfected with TP53 protein
Analysis of the immunopeptidome of Human Leukocyte Antigen(HLA)class I of SaOS-2 osteosarcoma cells transfected with pBR322 vector only, and 2 mutants of TP53 protein namely R175H and R273H.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD034044 | Pride
Hla Saos-2 Immunopeptidomics Tp53 protein Lc-ms/ms 
ProteomicsH3.3K27M HLA-A2 is not an effective immunotherapy target for diffuse midline glioma
The study investigated presentation of HLA A2 restricted H3.3K27M neopeptide using immunopeptidomics followed by DDA and/or targeted multiple monitoring reaction (MRM).
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038371 | Pride
Hla Car t cells H3.3 k27m Dipg Immunopeptidomics 
ProteomicsThe immunopeptidome and proteome of DIPG
DIPG is a devastating paediatric and young adult brainstem tumour with no cure and a median overall survival of 9 months. Cellular immunotherapy approaches require specific targeting of unique and tumour specific cell surface antigens, however, there is a paucity of known targets for DIPG. Here we u...
ORGANISM(S): Homo sapiens (Human) 
2023-09-25 | PXD038271 | Pride
Hla Proteomics Dipg Immunopeptidomics 
ProteomicsProteome of SUDIPG, SF7761 and primary non diseased brain samples
DIPG is a paediatric brainstem glioma with no cure. Cellular immunotherapy approaches require specific targeting of unique and tumour specific cell surface antigens, however, there is a paucity of known targets for DIPG. In this study we have used a proteomics approach to interrogate an array of pat...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038372 | Pride
Brain Bruker Dipg Proteomics S-trap Dda 
ProteomicsCombining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma
Checkpoint immunotherapy unleashes tumor control by T cells, but it is undermined in non-immunogenic tumors, e.g. with low MHC class I expression and low neoantigen burden, such as neuroblastoma (NB). Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that trims peptides before loading on M...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055268 | Pride
Mhc Immunotherapy Neuroblastoma Immunopeptidomics Erap 
ProteomicsPresentation of DNAJB1-PRKACA fusion neoantigens by different HLA class I alleles
Fibrolamellar carcinoma (FLC) is a liver tumor with a high mortality burden and few treatment options. A promising therapeutic vulnerability in this disease is its highly conserved driver mutation: a gene fusion between DNAJB1 and PRKACA, which is expressed in virtually all FLC tumors and could be a...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042316 | Pride
Fusion neoantigens Hla class i Cd8 t cell Dnajb1-prkaca Fibrolamellar carcinoma 
ProteomicsImmunopeptidome of an acute myeloid leukemia cell line THP1
We report the use of complementary peptide antigen enrichment and comprehensive mass spectrometric acquisition strategies to provide in-depth immunopeptidome data for AML cell line THP1
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-09 | MSV000087786 | MassIVE
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