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ProteomicsEpigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer
Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify a novel role of methionine adenosyltransferase 2a (MAT2A) as a driver of the androgen-indifferent state in ERG fusion-positive CRPC. We show...
ORGANISM(S): Homo sapiens (Human) 
2024-06-06 | PXD042895 | Pride
Androgen-indifferent state Castration-resistant prostate cancer Mat2a Erg Epigenomics 
ProteomicsStructure of ATTRv-F64S fibrils isolated from skin tissue of a living patient
Transthyretin-derived amyloidosis (ATTR) is a degenerative, systemic disease characterized by transthyretin fibril deposition in organs like the heart, kidneys, liver, and skin. We report the first cryo-EM structure of transthyretin fibrils isolated from skin tissue of a living patient with a rare g...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD065685 | Pride
Attr Cryo-em Diagnostic tool Mass spectrometry Transthyretin Amyloidosis 
ProteomicsMulti-omics Analysis of naive B cells of patients harboring the C104R mutation in TACI
Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary immunodeficiency in humans. The genetic cause of CVID is still unknown in about 70% of cases. 10% of CVID patients carry heterozygous mutations in the tumor necrosis factor receptor superfamily member 13B gene ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035459 | Pride
Atac-seq Cd40l stimulation Dna accessibility Proteomics Taci Tnfrsf13b Transcription factor Cvid Naïve b cells Nf-b Rna-seq 
ProteomicsTargeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output in Prostate Cancer
Activation of the androgen receptor (AR) is the key lineage-specific oncogenic pathway and the primary therapeutic target in prostate cancer. While AR signaling is enabled by the pioneer transcription factor FOXA1, its homolog FOXA2 is specifically expressed in advanced lineage plasticity prostate c...
ORGANISM(S): Homo sapiens (Human) 
2026-01-27 | PXD057803 | Pride
Foxa1 Ar negative prostate cancer Foxa2 Targeting transcription factor Chromatin 
ProteomicsInhibition of choline metabolism in an angioimmunoblastic T cell lymphoma preclinical model reveals a new treatment option
Background: Angioimmunoblastic T-cell lymphoma (AITL) is a malignancy with very poor survival outcome, in need of new more specific therapeutic regimen. The drivers of malignancy in this disease are CD4+ follicular helper T cells (Tfh). The metabolism of these malignant Tfh cells was not yet elucida...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-04 | PXD046786 | Pride
Choline kinase Choline Aitl Lipid metabolism Cdp-ethanolamine pathway T cell lymphoma Cdp-choline pathway Cancer therapy 
ProteomicsProteomics of immune cells from liver tumors reveals immunotherapy targets
Elucidating the mechanisms by which immune cells become dysfunctional in tumors is critical to developing next-generation immunotherapies. We profiled proteomes of cancer cells, monocyte/macrophages, CD4+ and CD8+ T cells, and NK cells isolated from tumors, liver, and blood of 48 patients with hepat...
ORGANISM(S): Homo sapiens (Human) 
2023-04-19 | PXD040957 | Pride
Nk cells Macrophages Immunotherapy Cd8 Hepatocellular carcinoma T cells Cd4 Monocytes 
ProteomicsBiofabrication of a 3D Human Skeletal Muscle Microenvironment to Study the Early Steps of Fibrosis
Skeletal muscle fibrosis is a prevalent characteristic of aging and dystrophies. Beyond myofibroblast involvement, recent findings highlighted a complex cellular cross-talk within the muscle microenvironment, finally resulting in vascular and tissue damage. This complexity is not captured by current...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD061757 | Pride
Biofabrication Endothelial-mesenchymal transition Microphysiological system Skeletal muscle Microvascular network 
ProteomicsMetabolic modulation of tumors with engineered bacteria for immunotherapy
The availability of L-arginine in tumors is a key determinant of an efficient anti-tumor T cell response. Consequently, elevation of typically low L-arginine levels within the tumor may greatly potentiate the anti-tumor responses of immune checkpoint inhibitors, such as PD-L1 blocking antibodies. H...
ORGANISM(S): Escherichia coli 
2021-07-13 | PXD027167 | Pride
Cancer immunotherapy L-arginine Synthetic biology Metabolic modulation of tumors Bacteria-based therapies 
ProteomicsDynamics in protein translation sustaining T cell preparedness
In response to pathogenic threats, naïve T cells rapidly transition from a quiescent to activated state, yet the underlying mechanisms are incompletely understood. Using a pulsed SILAC approach, we investigated the dynamics of mRNA translation kinetics and protein turnover in human naïve and activat...
ORGANISM(S): Homo sapiens (Human) 
2020-06-09 | PXD017159 | Pride
T cell activation T cell preparedness T cells 
UnknownMulti-domain destructuring in the early phases of psychosis: a multicentric phenomenological and psychometric case-control study.
Not available
S-EPMC12321885 | biostudies-literature
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