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ProteomicsHerpes simplex virus infections of cortical brain cells: the proteome and secretome of the host
Herpes simplex virus-1 (HSV-1) infections of the brain cause a severe neuroinflammatory condition – Herpes simplex encephalitis (HSE). During the acute phase, HSV-1 changes the host cells to facilitate its own replication and to escape host immunity. However, the host reacts with a severe neuroinfla...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018819 | Pride
Arfgap1 Glutathione Encephalitis Nek7 Inflammasome Hsv-1 Semaphorin Herpes simplex virus-1 Rab gtpases 
ProteomicsRole of Mincle overexpression in pneumococcal pneumonia
Macrophage-inducible C-type lectin (Mincle) dependent sensing of pathogens trig-gers proinflammatory immune responses in professional phagocytes that contribute to protect the host against pathogen invasion. Here, we examined whether overex-pression of Mincle designed to improve early pathogen sensi...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-05 | PXD018752 | Pride
Innate immunity Lung Mincle S. pneumoniae Nlrp3 Glc-dag 
ProteomicsSorafenib induces muscle wasting by disrupting the activity of distinct chromatin regulators
n cancer treatment regimens using chemotherapy, adverse effects can outweigh the benefits. Various chemotherapeutic drugs are linked to skeletal muscle wasting, drastically reducing the chance of survivability of cancer patients. Insights into the molecular basis of chemotherapy-induced cachexia is ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD054882 | Pride
Mitochondrial respiration Sarcomere organization Muscle contraction Cachexia Sorafenib Tyrosine kinase inhibitors 
ProteomicsMethyltransferase-like 3 (METTL3) regulates exocytosis
RNA modification pathways are often mis-regulated in various typers of cancer, with N6-methyladenosine (m6A) playing a pivotal role in cancer progression and metastasis. Methyltransferase-like 3 (METTL3), a core component of the m6A methyltransferase complex, functions not only as an m6A writer but ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-04 | PXD066045 | Pride
Exoc7 Breast cancer Rna modification Vesicle trafficking Exocyst N6-methyladenosine Mettl3 
ProteomicsExploring the Plasma Proteome Linked to Corpus Luteum Presence and Conception Mode Across Pregnancy Stages and Postpartum
Observational data suggest that women conceiving without a corpus luteum are at higher risk of developing preeclampsia. While the underlying mechanisms remain unclear, the absence of corpus luteum-derived secretory products may be a contributing factor. This study investigates whether the plasma pro...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD067974 | Pride
Frozen embryo transfer Mode of conception Unassisted conception Corpus luteum In vitro fertilization Proteome 
ProteomicsHEp-2 TcdB - Glucosyltransferase dependent and independent effects of TcdB on the proteome of HEp-2 cells
Human epithelial cell line HEp-2 was treated with Clostridium difficle toxin A. SILAC labeled samples were analyzed by shotgun LC-MS.
ORGANISM(S): Homo sapiens (Human) 
2017-06-20 | PXD006658 | Pride
Ltq-orbitrap velos Lc-msms Epithelial cell line Humen Clostridium difficile toxin b 
ProteomicsTcdB of Clostridioides difficile mediates necrosis in epithelial cells and is depend on RAS
A Clostridioides difficile infection (CDI) is the most common nosocomial infection worldwide. The main virulence factors are TcdA and TcdB, which inhibit small Rho-GTPases. Inhibition of small Rho-GTPases leads to the so-called cytopathic effect, a reorganization of the actin cytoskeleton, an impair...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD031726 | Pride
Clostridioides difficile  c.diff.  tcdb  phosphoproteomics  ras  tcda  pyknosis  glucosyltransferase independent effect 
ProteomicsC. Novyi's TcnA on HEp-2 cells, whole cell lysate Phosphoproteomics
The effect of TcnA on target cells is largely unexplored. Therefore, we performed a comprehensive screening approach of TcnA treated HEp-2 cells and analyzed their proteome and their phosphoproteome using LC-MS-based methods. With this data-dependent acquisition (DDA) approach, 5,086 proteins and 9,...
ORGANISM(S): Homo sapiens (Human) 
2022-09-02 | PXD036078 | Pride
Tcna  lcgts  c. difficile  tcda  tcdb  proteomics  pathway analysis  phosphoproteomics C. novyi  clostridium novyi 
ProteomicsEnvironment-driven changes of mRNA and protein levels in Pseudomonas aeruginosa
LFQ proteome datasets of Pseudomonas aeruginosa type strain PA14 cultured at different enviromental conditions: Exponential-, transition- and stationary(12 h and 24 h)growth phases. Biofilm (24 h and 48 h), low osmolarity conditions (control = exponential phase), iron starvation and respective contr...
ORGANISM(S): Pseudomonas aeruginosa (strain UCBPP-PA14) 
2018-11-20 | PXD010200 | Pride
Transcriptome Mass spectrometry Proteome Post-transcriptional regulation Random forest prediction Label-free quantification of proteins 
ProteomicsThe Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells
Phosphoproteomics Data of laryngeal carcinoma HEp-2 cells treated with CDT over 4h and 8h
ORGANISM(S): Homo sapiens (Human) 
2021-08-25 | PXD027411 | Pride
Phosphoproteomics Cdt Clostridioides difficile Tmt 
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