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ProteomicsBiomarkers of pediatric cataracts: a proteomics analysis of aqueous fluid
Abstract Background: Cataracts are among the most common causes of childhood vision loss worldwide. This study seeks to identify differentially expressed proteins in the aqueous humor of pediatric cataract patients. Methods: Samples of aqueous humor were collected from pediatric and adult cataract...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD022529 | Pride
Q-exactive Pediatric cataracts  proteomics  aqueous humor Lfq 
ProteomicsMevalonate pathway activity is a key determinant of radiation sensitivity in head and neck cancer
Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here we report a novel role for statin-based treatment of HNSCCs as an actionable and safe adjuvant to radiotherapy. Proteomic profiling and comparison of radiosensitive and radioresistant HNSCCs rev...
ORGANISM(S): Homo sapiens (Human) 
2019-06-25 | PXD007188 | Pride
Q-exactive Hnscc Pitavastatin Ddr Senescence Mevalonate pathway Lfq quantification. 
ProteomicsA Novel Method for Isolating Whole Protein from Human Cranial Bone
The presence of the extracellular matrix within human bone limits the applicability of conventional protocols for protein extraction. As a result, complete and accurate characterization of human bone proteome is yet to be performed, and as a result, several bone-related diseases such as craniosynost...
ORGANISM(S): Homo sapiens (Human) 
2016-10-05 | PXD003215 | Pride
Protein Extraction Method Cranial bone Q-exactive Human Proteome Whole protein 
ProteomicsGlobal Epigenetic Analysis Reveals H3K27 Methylation as a Mediator of Double Strand Break Repair
Ionizing Radiation is a ubiquitous cancer treatment modality which works in large part by inducing DNA Double Strand Breaks (DSBs). Recently, is has become apparent that chromatin surrounding DSBs is important for recognition of breaks, recruitment of repair factors, and timely DSB resolution. Here,...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD019388 | Pride
Q-exactive H2k27me3 Mrm Histone ptm Epiprofile 
ProteomicsGenetic analysis of Hsp70 phosphorylation sitesreveals a role in Candida albicanscell and colony morphogenesis
Heat shock proteins are best known for their role as chaperonins involved in general proteostasis, but they can also participate in specific cellular regulatory pathways, e.g. via their post-translational modification. Hsp70/Ssa1 is a central cytoplasmic chaperonin in eukaryotes, which also particip...
ORGANISM(S): Candida albicans (Yeast) 
2018-11-21 | PXD010827 | Pride
Candida albicans Hsp70 Mass spectrometry Q-exactive Post-translational modification Colony morphology Lfq quantification. 
ProteomicsChemotherapy-induced cellular senescence is characterized by aberrant lipid regulation and lipid peroxidation
As normal cells approach their proliferative limit, they arrest to undergo replicative senescence, displaying large cell size, flat morphology and activation of senescence-associated beta-galactosidase (SA-b-Gal). A subset of normal or tumor cells exposed in vitro or in vivo to chemotherapy agents s...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-06 | PXD006216 | Pride
Maxquant lfq Lipid peroxidation Mus Q-exactive Chemotherapy-induced senescence Quant proteomics 
ProteomicsTarget search for self-reactive antibodies in human renal allograft rejection
Self-reactive antibodies cloned from B cells infiltrating in a human renal allograft were subjected to IP-mass spectrometry using nuclear lysates of HEp-2 cells.
ORGANISM(S): Homo sapiens (Human) 
2021-04-27 | PXD022989 | Pride
Keywords: renal allograft rejection Transcription Q-exactive Inflammation Scrna-seq Human Human Innate b cells Autoantibodies Lfq Tolerance 
ProteomicsSubcellular localization of the J-protein Sis1 regulates the heat shock response
How heat shock inducesthe heat shock response (HSR) – a gene expression program encoding chaperones and other protein homeostasis (proteostasis) factors –remains an unresolved question in eukaryotic cell biology. Here we show that subcellular localization of the conserved J-protein Sis1 is a key reg...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-24 | PXD019170 | Pride
Hsf1 Heat shock Q-exactive Saccharomyces cerevisiae Sis1 J-protein 
ProteomicsRapid acetylation of yeast Hsp70 mediates the cellular response to heat stress
Hsp70 is a highly conserved molecular chaperone critical for the folding of new and denatured proteins. While traditional models state that cells respond to stress by upregulating inducible HSPs, this response is relatively slow and is limited by transcriptional and translational machinery. Recent s...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-24 | PXD015185 | Pride
Mass spectrometry Ptms Q-exactive Yeast Ssa1 Heat stress Acetylation 
ProteomicsCUX1 recruits SWI/SNF to promote chromatin accessibility in human hematopoietic cells
Transcription factors(TF) plays a key role in hematopoiesis via promoting cell-type specific gene expression. A subset of TFs, canonically termed “pioneer factors”, possesses the ability to bind to otherwise inaccessible heterochromatin regions, and recruit additional TFs, co-activators, and chromat...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD037838 | Pride
Human Q-exactive Ip-ms Cux1 Swi/snf Chromatin 
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