Sort   by:  
 Page size 
ProteomicsContribution of the Unfolded Protein Response (UPR) transcription factor XBP1 to brain aging
In this project we aimed to evaluate the contribution of endoplasmic reticulum stress sensor IRE1 and its downstream transcription factor XBP1s to mammalian brain aging. We compared traits associated to aging at behavioral, electrophysiological, morphological and proteomic levels. We used transgenic...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-04 | PXD020539 | Pride
Unfolded protein response Xbp1s Dementia Aging 
ProteomicsComparative Interactome Profiling of Nonstructural Protein 3 Across SARS-CoV-2 Variants Emerged During the COVID-19 Pandemic
SARS-CoV-2 virus and its variants have proven to be a threat to global health, in part due to their capacity for rapid evolution. SARS-CoV-2 variants that emerged throughout the COVID-19 pandemic exhibited variations in virulence, leading to diminished vaccine protection and modulating disease sever...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD061195 | Pride
Virus-host interactions Affinity purification-mass spectrometry Variants Nsp3 
ProteomicsDevelopment of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics
Liquid handling robots have been developed to automate various steps of the bottom-up proteomics workflow, however, protocols for the generation of isobarically labeled peptides remain limited. Existing methods often require costly specialty devices and are constrained by fixed workflows. To address...
ORGANISM(S): Homo sapiens (Human) 
2025-06-16 | PXD060786 | Pride
Automation Sample preperation Unfolded protein response and tandem mass tags 
ProteomicsPublic Cohort Analysis Identifies Thyroglobulin Variants as Hypothyroidism Risk Factors
Hypothyroidism is a prevalent endocrine disorder that is characterized by the insufficient production of thyroid hormones (T3/T4), with etiologies related to environmental, autoimmune factors, or genetic variants. Thyroglobulin (Tg) serves as the prohormone to T3/T4 production and due to a large gen...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2026-08-07 | PXD069688 | Pride
Ap-ms Tmt Hypothyroidisim Lc-ms/ms 
ProteomicsDistinct proteostasis states drive pharmacologic chaperone susceptibility for Cystic Fibrosis Transmembrane Conductance Regulator misfolding mutants
Pharmacological chaperones represent a class of therapeutic compounds for treating protein misfolding diseases. One of the most prominent examples is the FDA-approved pharmacological chaperone lumacaftor (VX-809), which has transformed cystic fibrosis (CF) therapy. CF is a fatal disease caused by mu...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD032836 | Pride
Cystic fibrosis Protein quality control Corrector Interactomics Affinity-purification mass spectrometry (ap-ms) Theratype Tandem mass tags 
ProteomicsComparative Thyroglobulin Interactome Profiling
Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for T3 and T4 hormones. Many characterized Tg gene mutations produce secretion-defective variants resulting in congenital hypothyroidism (CH). Tg processing and secretion is controlled by extensive interactions with chaperone...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD019427 | Pride
Protein quality control Interactomics Thyroglobulin Congenital hypothyroidism Quantitative proteomics Ap-ms Proteostasis Protein folding 
ProteomicsComparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs
Human coronaviruses have become an increasing threat to global health; three highly pathogenic strains have emerged since the early 2000s, including most recently SARS-CoV-2, the cause of COVID-19. A better understanding of the molecular mechanisms of coronavirus pathogenesis is needed, including ho...
ORGANISM(S): Homo sapiens (Human) 
2021-07-01 | PXD024566 | Pride
Ap-ms Sars-cov-2 Covid-19 
ProteomicsPhotoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target
Cystic fibrosis (CF) pharmacological correctors such as VX-445 are used in combinations as highly effective modulator therapy (HEMT) at CF clinics due to their efficacy in improving Cystic Fibrosis transmembrane conductance regulator (CFTR) protein trafficking and function. Yet, several side-effects...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD060898 | Pride
Elexacaftor Cystic fibrosis (cf) Vu439 Click chemistry Target identification Cystic fibrosis transmembrane conductance regulator (cftr) Off-target Mass spectrometry (ms) Proteomics Diazirine Metabolomics Chemoproteomics Corrector Photoaffinity ligand (pal) Vx-445 Saccharopine dehydrogenase-like oxidoreductase (sccpdh) 
ProteomicsExpression profiling of mouse embryonic stem cells by mass spectrometry
Embryonic stem cells from B6 and NOD backgrounds were derived freshly in the presence of 2i. After 3-5 passages on feeders, ES cells were cultured in 2i media without any feeders for several passages. In order to identify differentially expressed genes and proteins, we performed RNA-Seq and mass spe...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-31 | PXD020055 | Pride
Lc-msms B6 Esc Nod 
TranscriptomicsThe tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse
The histone modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the activation state of genes controlling pluripotency, lineage commitment, and cell differentiation. Long non-coding RNAs (lncRNAs) can bind to either complex, and some have been shown to act as modulators of PRC2 o...
ORGANISM(S): Mus musculus 
2013-01-28 | E-GEOD-43078 | biostudies-arrayexpress
Sort   by:  
 Page size