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ProteomicsProteomics data for "A single-amino-acid cleavage controls global mitochondrial complex integrity"
Mitochondrial proteostasis depends on precise N-terminal processing of imported precursor proteins, and defects in this maturation step are implicated in severe human diseases, yet the functional impact in humans remain unclear. This dataset analysis quantiative changes in the proteome of mitochondr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-01 | PXD070247 | Pride
N-terminome Mitochondria Protein complex stability Respiratory chain Proteomics 
ProteomicsQuantitative Myogenesis C2C12 Proteome with Dimethyl-Labelling
The Z-disc is a protein-rich structure critically important for myofibril development and integrity. In order to monitor the quantiative changes in C2C12 myoblast during myogenesis, a quantitative dimethyl-labelling approach was performed with d0 myoblasts, d5 myotubes and electrical puls stimulated...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-02 | PXD004960 | Pride
Muscle differentiation Myoblasts Dimethyl C2c12 cells Myotubes 
ProteomicsBenchmarking of different methods for obtaining high quality secretomics data
The main drawback of secretome analyses are contaminating proteins derived from culture medium or proteins released from dying cells which are hard to distinguish from proteins actively secreted by cells. Therefore, several approaches have been applied allowing to remove contamination from secretome...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD018895 | Pride
Supernatant Secretomics Secreteome Benchmarking Conditioned medium 
ProteomicsDog platelets proteome by label-free quantiative LC-MS/MS analysis
Proteomic analyses of the proteins secreted from dog platelets using label-free quantitationworkflow.
ORGANISM(S): Equus caballus (Horse) 
2019-10-29 | PXD015864 | Pride
Platelets Shutgun proteomics Lfq Dog Lc-ms/ms 
ProteomicsMassive Proteome Remodelling by HIV Vpr
Viruses target host proteins for degradation to enhance their replication and transmission, and identifying these targets has provided key insights into the host-pathogen interaction1-3. Here, we use complementary unbiased mass spectrometry-based approaches to dissect the widespread proteomeic remod...
ORGANISM(S): Homo sapiens (Human) 
2019-05-01 | PXD013221 | Pride
Hiv Tmt Vpr 
ProteomicsLabel-Free Quantiative Analysis of Sepioloidea lineolata
Sepioloidea lineolata, the striped pyjama squid (family Sepidariidae), is a small species of benthic squid distributed along the Southern Indo-Pacfic coast of Australia. All Sepiadariid squids are known to secrete large volumes of viscous slime when stressed. The proteome of the slime, dorsal and ve...
ORGANISM(S): Sepioloidea lineolata 
2020-02-25 | PXD013436 | Pride
Secretion Squid : slime Differential expression Gland Label-free quantitation Cephalopod 
ProteomicsZinc limitation in Klebsiella pnuemoniae
Nutrient adaptation is key in limiting environments for the promotion of microbial growth and survival. In microbial systems, zinc is an important component for many cellular processes and bioavailability varies greatly among different conditions. In the bacterium, Klebsiella pneumoniae, the impact ...
ORGANISM(S): Klebsiella pneumoniae 
2021-02-12 | PXD016042 | Pride
Virulence Klebsiella Transport Quantiative proteomics Zinc Proteome Secretome 
ProteomicsFunctional proteomic atlas of HIV-infection in primary human CD4+ T cells
Viruses manipulate host cells to enhance their replication, and the identification of host factors targeted by viruses has led to key insights in both viral pathogenesis and cellular physiology. We previously described global changes in cellular protein levels during human immunodeficiency virus (HI...
ORGANISM(S): Homo sapiens (Human) 
2019-03-08 | PXD012263 | Pride
Proteomics Hiv Primary t-cells 
ProteomicsSus scrofa, skeletal muscle, LC-MSMS
Skeletal muscle were collected from pigs treated in the control group, the Lys deficiency group and the Lys rescue group. Then, the samples were analyzed by LC-MSMS.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-05-27 | PXD016396 | Pride
Lc-msms Skeletal muscle Sus scrofa 
ProteomicsALK signalling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition
Phosphoproteomics DIA LC-MSMS analysis Phospho-enriched peptides were resuspended in aqueous formic acid and 0.2 ug of peptides subjected to LC-MS/MS analysis using an Orbitrap Exploris 480 Mass Spectrometer fitted with an Vanquish Neo (both Thermo Fisher Scientific) and a custom-made column heater ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-30 | MSV000092789 | MassIVE
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