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ProteomicsIdentification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease
Gaucher disease, a recessive inherited metabolic disorder caused by defects in the gene encoding glucosylceramidase (GlcCerase), can be divided into three subtypes according to the appearance of symptoms associated with central nervous system involvement. We now identify a protein, glycoprotein non-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080786 | MassIVE
ProteomicsTargeting CD38 immunometabolic checkpoint improves metabolic fitness and cognition in a mouse model of Alzheimer’s disease
Protective immunity, essential for brain maintenance and repair, may be compromised in Alzheimer’s disease (AD). Here, using high-dimensional single-cell mass cytometry, we find a unique immunometabolic signature in circulating CD4+ T cells preceding symptom onset in individuals with familial AD, fe...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-08 | PXD060761 | Pride
Lc-msms Mus musculus Cd38 Csf Alzheimer's disease 
ProteomicsMimivirus Replication Factories
Proteomic analysis of isolated viral factories along a timeline after infection of the amoeba Acanthamoeba polyphaga by the giant Mimivirus
ORGANISM(S): Acanthamoeba polyphaga mimivirus (APMV) Acanthamoeba polyphaga 
2018-10-26 | PXD004203 | Pride
Mimivirus Viral factories 
ProteomicsTwo opposing redox signals mediated by 2-Cys peroxiredoxin shape the redox proteome during photosynthetic induction
Photosynthetic induction, characterized by the lag in CO2 assimilation rates during transition from darkness to light, has traditionally been attributed to Rubisco activase activity and stomatal opening. Yet, the faster induction of photosynthesis in the 2-Cys peroxiredoxins (Prxs) mutant (2cpab) su...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-08-25 | PXD065993 | Pride
Arabidopsis Photosynthesis induction Redox proteomics N-ethylmaleimide Redox signaling Nem 2-cys peroxiredoxins 
ProteomicsTwo opposing redox signals mediated by 2-Cys peroxiredoxin shape the redox proteome during photosynthetic induction
Photosynthetic induction, characterized by the lag in CO2 assimilation rates during transition from darkness to light, has traditionally been attributed to Rubisco activase activity and stomatal opening. Yet, the faster induction of photosynthesis in the 2-Cys peroxiredoxins (Prxs) mutant (2cpab) su...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-08-25 | PXD065702 | Pride
Photosynthesis induction Redox proteomics Lc-ms Redox signaling Spear 2-cys peroxiredoxins 
ProteomicsIdentification of PRRC2B methylation sites
It was hypothesized that the human PRRC2B protein (Uniprot accession Q5JSZ5) interacts with its RNA binding targets via methylated arginines. The protein contains at least two RG rich motifs (residues 1061-1080, and 1104-1124), in which the arginines are hypothesized to be methylated. The goal of th...
ORGANISM(S): Homo sapiens (Human) 
2025-10-26 | PXD057790 | Pride
Methylation Prrc2b Ip Chymotrypsin Dap5 Lc-ms/ms 
ProteomicsNext Generation Protein Sequencing
NGPS is a method for de-novo, full-length protein sequencing in high throughput. The method is based on cleavage of the protein at semi-random sites by microwave-assisted acid hydrolysis (MAAH), enrichment of LC-MS/MS amenable peptides from the hydrolysate by solid-phase-extraction, LC-MS/MS analysi...
ORGANISM(S): Bos taurus (Bovine) Equus caballus (Horse) 
2017-04-03 | PXD003804 | Pride
Full length Maah De-novo Ngps Microwave 
ProteomicsIdentification and characterization of β-ODAP synthase in grass pea
Grass pea seeds and seedlings protein extracts were chromatographically fractionated. To identify the β-ODAP synthase enzyme, active fractions, as determined by a colorimetric assay that detects the presence of a derivative of free L-α,β-diaminopropionic acid (L-DAPA), were subjected to tryptic dige...
ORGANISM(S): Lathyrus sativus 
2022-05-19 | PXD030847 | Pride
Proteomics Toxin Lathyrus sativus Trascriptome Grass pea Beta-odap synthetase 
ProteomicsErk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes rigorous negative feedback loop on the RTK-Ras-Raf-MEK pathway
The extracellular signal-regulated kinases (Erks), Erk1 and Erk2, are crucial components of the receptor tyrosine kinase (RTK)-Ras-Raf-MEK pathway, which is frequently mutated and constitutively activated in various cancers. Despite Erk activity being commonly observed in cancer, the role of direct ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD056168 | Pride
Proteomics Phosphorylation Mapk Phosphoproteomics Kinase Autoactivation Erk 
ProteomicsErk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes rigorous negative feedback loop on the RTK-Ras-Raf-MEK pathway- Global proteomics
The extracellular signal-regulated kinases (Erks), Erk1 and Erk2, are crucial components of the receptor tyrosine kinase (RTK)-Ras-Raf-MEK pathway, which is frequently mutated and constitutively activated in various cancers. Despite Erk activity being commonly observed in cancer, the role of direct ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD058196 | Pride
Proteomics Phosphorylation Mapk Phosphoproteomics Kinase Autoactivation Erk 
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