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ProteomicsIdentification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease
Gaucher disease, a recessive inherited metabolic disorder caused by defects in the gene encoding glucosylceramidase (GlcCerase), can be divided into three subtypes according to the appearance of symptoms associated with central nervous system involvement. We now identify a protein, glycoprotein non-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080786 | MassIVE
ProteomicsMimivirus Replication Factories
Proteomic analysis of isolated viral factories along a timeline after infection of the amoeba Acanthamoeba polyphaga by the giant Mimivirus
ORGANISM(S): Acanthamoeba polyphaga mimivirus (APMV) Acanthamoeba polyphaga 
2018-10-26 | PXD004203 | Pride
Mimivirus Viral factories 
ProteomicsTwo opposing redox signals mediated by 2-Cys peroxiredoxin shape the redox proteome during photosynthetic induction
Photosynthetic induction, characterized by the lag in CO2 assimilation rates during transition from darkness to light, has traditionally been attributed to Rubisco activase activity and stomatal opening. Yet, the faster induction of photosynthesis in the 2-Cys peroxiredoxins (Prxs) mutant (2cpab) su...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-08-25 | PXD065993 | Pride
Arabidopsis Photosynthesis induction Redox proteomics N-ethylmaleimide Redox signaling Nem 2-cys peroxiredoxins 
ProteomicsTwo opposing redox signals mediated by 2-Cys peroxiredoxin shape the redox proteome during photosynthetic induction
Photosynthetic induction, characterized by the lag in CO2 assimilation rates during transition from darkness to light, has traditionally been attributed to Rubisco activase activity and stomatal opening. Yet, the faster induction of photosynthesis in the 2-Cys peroxiredoxins (Prxs) mutant (2cpab) su...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-08-25 | PXD065702 | Pride
Photosynthesis induction Redox proteomics Lc-ms Redox signaling Spear 2-cys peroxiredoxins 
ProteomicsNext Generation Protein Sequencing
NGPS is a method for de-novo, full-length protein sequencing in high throughput. The method is based on cleavage of the protein at semi-random sites by microwave-assisted acid hydrolysis (MAAH), enrichment of LC-MS/MS amenable peptides from the hydrolysate by solid-phase-extraction, LC-MS/MS analysi...
ORGANISM(S): Bos taurus (Bovine) Equus caballus (Horse) 
2017-04-03 | PXD003804 | Pride
Full length Maah De-novo Ngps Microwave 
ProteomicsIdentification and characterization of β-ODAP synthase in grass pea
Grass pea seeds and seedlings protein extracts were chromatographically fractionated. To identify the β-ODAP synthase enzyme, active fractions, as determined by a colorimetric assay that detects the presence of a derivative of free L-α,β-diaminopropionic acid (L-DAPA), were subjected to tryptic dige...
ORGANISM(S): Lathyrus sativus 
2022-05-19 | PXD030847 | Pride
Proteomics Toxin Lathyrus sativus Trascriptome Grass pea Beta-odap synthetase 
ProteomicsErk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes rigorous negative feedback loop on the RTK-Ras-Raf-MEK pathway
The extracellular signal-regulated kinases (Erks), Erk1 and Erk2, are crucial components of the receptor tyrosine kinase (RTK)-Ras-Raf-MEK pathway, which is frequently mutated and constitutively activated in various cancers. Despite Erk activity being commonly observed in cancer, the role of direct ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD056168 | Pride
Proteomics Phosphorylation Mapk Phosphoproteomics Kinase Autoactivation Erk 
ProteomicsSalmonella Skp mutant proteomics
Global discovery proteomic investigation of Salmonella typhimurium (control strain, Antibiotic resistant, or AcrB mutant) was performed in order to identify cellular processes affected by AcrB.
ORGANISM(S): Salmonella typhimurium (strain 14028s / SGSC 2262) Bacteria 
2020-05-27 | PXD014818 | Pride
Acrb Salmonella typhimurium S-trap Lc-ms/ms 
ProteomicsErk1R84H is an oncoprotein that causes hepatocellular carcinoma in mice and imposes rigorous negative feedback loop on the RTK-Ras-Raf-MEK pathway- Global proteomics
The extracellular signal-regulated kinases (Erks), Erk1 and Erk2, are crucial components of the receptor tyrosine kinase (RTK)-Ras-Raf-MEK pathway, which is frequently mutated and constitutively activated in various cancers. Despite Erk activity being commonly observed in cancer, the role of direct ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-04 | PXD058196 | Pride
Proteomics Phosphorylation Mapk Phosphoproteomics Kinase Autoactivation Erk 
ProteomicsBLM helicase protein negatively regulates stress granule formation through unwinding RNA G-quadruplex structures
Bloom’s syndrome (BLM) protein is a known nuclear helicase that is able to unwind DNA secondary structures such as G-quadruplexes. However, its role in the regulation of cytoplasmic processes that involve RNA G-quadruplexes (rG4s) has not been previously studied. Here, we demonstrate that BLM is rec...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039534 | Pride
Stress granule Apex Helicase Lc-msms G-quadruplex Rg4-binding proteins Blm Quma-1 
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