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ProteomicsTranscriptional and proteomic dynamics of severe fever with thrombocytopenia syndrome virus infection in Rhipicephalus microplus cells identify antiviral host factors.
Ticks are vectors of arboviruses in many parts of the world. The rising incidence and emergence of tick-borne arboviral infections across human populations indicates that further transmission control strategies including those based on vectors, will be required to reduce the burden of disease. Howev...
ORGANISM(S): Severe fever with thrombocytopenia syndrome virus Rhipicephalus microplus Bunyavirales 
2025-05-26 | PXD052311 | Pride
Sftsv Ap-ms/ms Rhipicephalus microplus Severe fever with thrombocytopenia syndrome 
ProteomicsStress granule phase separation in stress-responsive cytosolic extract-in-oil droplets
Stress granules (SGs) are biomolecular condensates that transiently form in the cytosol when cells are exposed to potentially hazardous conditions. Illustrating the physiological relevance of SGs, dysregulation of pathways leading to their assembly or disassembly is increasingly associated with huma...
ORGANISM(S): Homo sapiens (Human) 
2026-05-19 | PXD057906 | Pride
Droplet-based Integrated stress response Microfluidics Dsrna Biomolecular condensates G3bp1 Stress granules Liquid-liquid phase separation 
ProteomicsMulti-omics analysis of arboviral capsid targets in mosquitoes reveals a pro-viral function of the chromatin-remodeling Brahma complex
In recent years, arboviral infections have surged dramatically due to the geographic expansion of Aedes and Culex mosquitoes, their main vector mosquitoes. Despite significant efforts to uncover arbovirus–host interactions and viral protein effector functions in mammals, systematic studies aiming to...
ORGANISM(S): Aedes aegypti 
2026-02-05 | PXD070116 | Pride
ProteomicsDengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis
With no therapeutics available, there is an urgent need to better understand the pathogenesis of (ortho)flaviviruses which constitute a threat to public health worldwide. During infection, dengue virus (DENV) and Zika virus (ZIKV), two flavivirusesinduce alterations of mitochondria morphology to fav...
ORGANISM(S): Homo sapiens (Human) Dengue virus 
2024-12-20 | PXD057947 | Pride
Dengue virus (denv) Contact sites Viral infection Respiration Mitochondria Apoptosis Zika virus (zikv) 
ProteomicsMembrane tethering by the host ER-resident GTPase Atlastin-2 is critical for flavivirus replication
Flaviviruses (genus Orthoflavivirus) are arthropod-borne viruses which cause approximately 400 million annual global infections in humans. As obligate intracellular pathogens, flaviviruses must co-opt cellular machinery to facilitate their infection and spread. Notably, all flaviviruses replicate in...
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD068694 | Pride
Atl2 Orthoflavivirus Er remodeling 
ProteomicsTranscriptomic and proteomic landscape of SARS-CoV-2 liver tropism
Extrapulmonary manifestations of COVID-19 have gained attention, not only due to their links to clinical outcomes, but also due to their potential long-term sequelae1. Recent evidence has shown multi-organ tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including heart, kidn...
ORGANISM(S): Homo sapiens (Human) 
2022-04-02 | PXD022789 | Pride
Sars-cov-2 Liver tropism Hepatic 
ProteomicsER-shaping Atlastin proteins differentially contribute to flavivirus replication and assembly
Flaviviruses, including Dengue virus (DV) and Zika virus, extensively remodel the cellular endomembrane network to generate replication organelles that promote viral genome replication and virus production. However, it remains unclear how these membranes and associated cellular proteins act during t...
ORGANISM(S): Homo sapiens (Human) 
2019-10-17 | PXD014639 | Pride
Atl-2 Atlastin Atl-3 Proteome Ap-lc-ms/ms 
ProteomicsProteome of LGALS3BP-depleted HeLa cells
Interferon-stimulated genes (ISGs) form the backbone of innate immune system and are pivotal for limiting intra- and intercellular viral replication and spread. We conducted a mass spectrometry–based survey to understand the fundamental organization of the innate immune system and to explore molecul...
ORGANISM(S): Homo sapiens (Human) 
2019-03-01 | PXD012276 | Pride
Lgals3bp Lfq Label-free Qexactive 
ProteomicsProteome of HEK293T cells upon P2YR6 overexpression
Defense against virus infections relies on rapid and massive engagement of cellular proteins with antiviral properties. Germline-encoded pattern recognition receptors (PRRs) sense the presence of pathogens and initiate a signaling cascade leading to the induction of antiviral cytokines, including ty...
ORGANISM(S): Homo sapiens (Human) 
2019-03-01 | PXD012277 | Pride
P2yr6 Label-free quantification Lfq Qexactive 
ProteomicsProteome of CNOT1 and ANXAR2-depleted cells
Interferon-stimulated genes (ISGs) form the backbone of innate immune system and are pivotal for limiting intra- and intercellular viral replication and spread. We conducted a mass spectrometry–based survey to understand the fundamental organization of the innate immune system and to explore molecul...
ORGANISM(S): Homo sapiens (Human) 
2019-03-01 | PXD012278 | Pride
Anxar2 Cnot1 Label-free Proteome Lfq 
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