Sort   by:  
 Page size 
TranscriptomicsAnalysis of the Infrared-A radiation induced transcriptom of human skin fibroblasts.
Background: Infrared A radiation (IRA 760-1440 nm) is a major component of solar radiation and, similar to ultraviolet (UV) radiation, causes photoaging of human skin by increasing the expression of matrixmetalloproteinase-1 (MMP-1) expression in human skin fibroblasts. This gene-regulatory effect ...
ORGANISM(S): Homo sapiens 
2010-07-10 | E-GEOD-17046 | biostudies-arrayexpress
TranscriptomicsHigh-resolution analysis of copy number changes in circulating and disseminated tumor cells in breast cancer patients
The aim of this study was to establish a single-cell array comparative genomic hybridization (SCaCGH) method providing in-depth genomic analysis of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs). The robustness and resolution limits of the method were estimated with different cel...
ORGANISM(S): Homo sapiens 
2012-11-19 | E-GEOD-27574 | biostudies-arrayexpress
ProteomicsLipid nanotubes unmask neutrophils for complement attack
Neutrophils, critical components of innate immunity, undergo significant morphological changes during phagocytosis. In this study, we demonstrate that neutrophils exposed to shear stress generate lipid nanotubes (NTs) with a unique composition. Compared to the proteome of whole neutrophils, NTs nota...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD064111 | Pride
Complement system Shear stress Extracellular vesicles Neutrophils Polytrauma Vasculitis 
ProteomicsA peptide-based tolerizing vaccine against autoimmune arthritis directly interacting with antigen-specific T cells
A longstanding goal has been to find an antigen-specific preventive therapy, i.e., a vaccine, for autoimmune diseases. Major hindrances have so far been to select natural regulatory antigen targets and side-effects induced by clustering the T cell receptor (TCR) or activating the costimulatory signa...
ORGANISM(S): Mus musculus (Mouse) 
2023-06-15 | PXD034792 | Pride
Autoimmune arthritis Arthritis Antigen-specific t cells Vaccine 
ProteomicsInterferon-induced degradation of the hepatitis B virus persistence form, cccDNA, depends on ISG20
Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Cytokine treatments can diminish HBV cccDNA via APOBEC3-mediated deamination. Here we show that overexpression of APOBEC3A alone,...
ORGANISM(S): Homo sapiens (Human) 
2021-04-22 | PXD019285 | Pride
Isg20 Apobec3a Hbv Interferon-gamma Cccdna Chronic hepatitis b Interferon-alpha 
ProteomicsRHOT proteins link mitochondrial motility to cardiomyocyte sarcomere maturation
Proteome analysis of RHOT1/2 interaction partners based on affinity purification.
ORGANISM(S): Mus musculus (Mouse) 
2026-04-30 | PXD069743 | Pride
Rhot1 Heart Rhot2 Mouse 
UnknownSingle-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury.
Not available
S-EPMC9462075 | biostudies-literature
TranscriptomicsSuppression of NCALD protects against spinal muscular atrophy by restoring impaired endocytosis
Spinal muscular atrophy (SMA) is a common genetic motor neuron (MN) disease caused by low levels of the ubiquitously expressed housekeeping survival motor neuron (SMN) protein, whereas concomitant overexpression of plastin 3 (PLS3) protects from SMA. Here we identify neurocalcin delta (NCALD), a neu...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-58316 | biostudies-arrayexpress
UnknownGenome-wide association study in essential tremor identifies three new loci.
Not available
S-EPMC5382938 | biostudies-literature
Genomicsena-DATASET-RTL-11-03-2015-12:07:49:303-16 - samples
Whole genome sequencing was performed with DNA extracted from fresh-frozen tumor and normal material. Short insert DNA libraries were prepared with the TruSeq DNA PCRfree sample preparation kit (Illumina) for paired-end sequencing at a minimum read length of 2x100bp. Human DNA libraries were sequenc...
EGAD00001001273 | EGA
Sort   by:  
 Page size