Sort   by:  
 Page size 
ProteomicsCo-translational and Post-translational protein myristoylation in HeLa cells
Protein N-myristoylation is a ubiquitous co- and post-translational modification that has been implicated in the development and progression of a range of human diseases. In E. Thinon, R. A. Serwa, et al., Nature Communications 2014, doi:10.1038/ncomms5919, we report the global N-myristoylated prote...
ORGANISM(S): Homo sapiens (Human) 
2018-07-31 | PXD002687 | Pride
Co-translational modification Post-translational modification Apoptosis Protein myristoylation 
ProteomicsMass spectrometry analysis of synaptic proteome of adult Fmr1 KO and wild-type mice.
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins. Although this upregulation stabilizes in the adu...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD043700 | Pride
Brain Synaptoneurosomes Fmr1 ko mice 
ProteomicsProfiling N-myristoyltransferase activity and inhibition in breast cancer cells (MD-MB-231) using Sortase-A labelling
We report a novel application for Sortase A (SrtA), labeling N-terminal Gly proteins across the proteome at endogenous levels. We combined SrtA labeling of whole-cell lysates with a potent and selective NMT inhibitor, delivering a method capable of quantifying changes in cellular NMT activity in mul...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD010634 | Pride
Sortase a  srta  n-myristoylation  nmt 
ProteomicsS-palmitoylation of synaptic proteins in rat synaptoneurosomes
Temporal and target-specific S-palmitoylation of synaptic proteins supports synapse and neural network plasticity: Synaptic plasticity is a phenomenon essential for learning and memory, which relies on activity-dependent changes in neural connectivity. S-palmitoylation, a reversible posttranslation...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-10-20 | PXD058417 | Pride
Ltp stimulation Synaptoneurosomes Acyl-biotin exchange S-palmitoylation 
ProteomicsProteomic profile of (Laser-dissected) Motoneurons, Ependymal Cells and Dorsal Root Ganglia Cells, and after Spinal Cord Injury in Rat
Spinal cord injury triggers extensive molecular remodeling in neural and glial compartments. To resolve these processes at cell-type-specific resolution, we performed quantitative proteomic profiling of laser-microdissected motor neurons (MNs), dorsal root ganglia (DRG), and ependymal cells (EC) fro...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-03-13 | PXD070428 | Pride
Motorneurons Dorsal root ganglia Spinal cord injury Laser microdissection Tmt-based proteomics 
ProteomicsProtein interactors of 5-FU in MDA-MB-231 cells
This dataset originates from a Proteome Integral Solubility Alteration (PISA) experiment designed to assess how 5-fluorouracil (5-FU) alters protein thermal stability/solubility in MDA-MB-231 cells. Cells were treated with 200 μM 5-FU or DMSO for 2 h, exposed to a temperature gradient, lysed, and so...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD072095 | Pride
5-fluorouracil Mda-mb-231 5-fu Pisa 
ProteomicsAging-triggered iron-rich insoluble protein aggregates in the spleen originate chiefly from red pulp macrophages.
Both iron homeostasis and erythropoiesis are known to be affected by aging. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by red pulp macrophages (RPMs) in the spleen. Given that RPMs continuously process iron, their cell...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-02 | PXD038660 | Pride
Iron-rich protein aggregates Iron-dextran injection Mouse Red pulp macrophages Spleen 
ProteomicsImpaired iron recycling from erythrocytes is an early hallmark of aging
Both iron homeostasis and erythropoiesis are known to be affected by aging. Iron needs in mammals are met primarily by iron recycling from senescent red blood cells (RBCs), a task chiefly accomplished by red pulp macrophages (RPMs) in the spleen. Given that RPMs continuously process iron, their cell...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-02 | PXD032900 | Pride
Ferritin Iron-recycling Ferroportin Proteostasis Hepcidin 
ProteomicsLiver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Mild hemolysis of senescent erythrocytes occurs physiologically in the spleen resulting in Hb release, whereas pathologic erythrocyte rupture characterizes several diseases. Iron recycling from Hb and Hb detoxification have been attributed to the sequestration of Hb-haptoglobin complexes by macropha...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-12 | PXD051274 | Pride
Mouse Liver sinusoidal endothelial cells Hemoglobin clearance 
ProteomicsTIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment
Chronic myeloid leukemia (CML) cells circulate between blood and bone marrow niche, representing different microenvironments. We studied the role of the two RNA binding proteins, T-cell-restricted intracellular antigen (TIAR) and the fragile X mental retardation protein (FMRP) in the regulation of p...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD032332 | Pride
Quancat Fmrp Chronic myeloid leukemia Tiar 
Sort   by:  
 Page size