Sort   by:  
 Page size 
ProteomicsPCNA has specific functions in regulation of metabolism in haematological cells
PCNA´s essential roles in DNA replication and repair are well established, while it’s recently discovered non-canonical roles in cellular signalling and regulation of metabolism are less explored. Recent data has indicated that PCNA has a specific non-canonical role in cells of haematological origin...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD017474 | Pride
Pi3k/akt pathway Metabolomics Systems-level study Signalome Cell signalling Redox metabolism Apim Central carbon metabolism Kinome 
ProteomicsA novel truncated form of Nephronectin is present in small extracellular vesicles isolated from 66cl4-cells
Extracellular vesicles are quickly emerging as biomarkers in breast cancer. Our recent report suggested that an intracellular granular staining pattern of the extracellular matrix protein Nephronectin (NPNT) in breast tumor sections correlated with poor prognosis. In this study we performed proteomi...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-15 | PXD010999 | Pride
Small extracellular vesicles Maxlfq Breast cancer Proteome Nephronectin 
ProteomicsUnravelling the Proteomic Landscape of Imipenem Resistance in Pseudomonas aeruginosa: A Comparative Investigation between Clinical and Control Strains
The proteomic landscape of Pseudomonas aeruginosa under the influence of Imipenem, a commonly used antibiotic, has been the subject of investigation in this study. Our comparative analysis between the world epidemic clinical strain (6378/09) and the control strain (ATCC 27853)has revealed results hi...
ORGANISM(S): Pseudomonas aeruginosa ATCC 700888 
2026-04-13 | PXD055744 | Pride
Antimicrobial resistance Antibiotic challenge Pseudomonas aeruginosa Label-free quantitative proteomics Imipenem . 
ProteomicsTargeting PCNA in a subgroup of Multiple Myeloma cells inhibits the glycolysis and pentose phosphate pathway
PCNA is an essential protein in all cells with multiple well-known function in DNA replication and DNA repair. Recently, PCNA was shown to be involved in regulation of cellular signalling and central carbon metabolism via stabilizing the metabolic enzymes ENO1 and 6PGD. Furthermore, ATX-101, a PCNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD033510 | Pride
Targeting Pentose phosphate pathway Tk Multiple myeloma Cells Glycolysis Mib assay Pcna 
ProteomicsTargeting PCNA in a subgroup of Multiple Myeloma cells inhibits the glycolysis and pentose phosphate pathway (batch TK9)
PCNA is an essential protein in all cells with multiple well-known function in DNA replication and DNA repair. Recently, PCNA was shown to be involved in regulation of cellular signalling and central carbon metabolism via stabilizing the metabolic enzymes ENO1 and 6PGD. Furthermore, ATX-101, a PCNA ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-25 | PXD033531 | Pride
Targeting Pentose phosphate pathway Tk Multiple myeloma Cells Glycolysis Mib assay Pcna 
ProteomicsProteomic analysis of breast EMT cell models reveal UGDH is upregulated during EMT and holds the potential as a clinical target
Epithelial–mesenchymal transition (EMT) is known to be involved in cancer metastasis and pathogenesis. Metabolic re-wiring is now considered to be one of the hallmarks of cancer. In this study, we studied the metabolic changes during EMT in three breast EMT cell models with a proteomic approach. The...
ORGANISM(S): Homo sapiens (Human) 
2022-01-04 | PXD024164 | Pride
Cell model Emt Upregulated Ugdh Breast Biomarker 
ProteomicsUse of a modified Multiplexed Inhibitor Bead assay to study kinome responses to cytostatic treatment in human cancer cell lines
In order to improve elution of proteins from the column, to reduce the cost as well as the hands on time of the analysis, we here present a modification of the Multiplexed Inhibitor Bead assay (MIB assay), where we elute the proteins from beads containing covalently bound inhibitors using trypsin di...
ORGANISM(S): Hordeum vulgare (Barley) 
2017-02-13 | PXD005286 | Pride
Kinome Mib 
ProteomicsOff-target responses in the HeLa proteome subsequent to transient plasmid transfection using SILAC
We report a significant differential expression of proteins, all of which are associated with a viral infection response typified by Interferon type I/II. Notably the upregulated proteins may affect several vital cellular processes, including cell cycle control, translation and post-translational m...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-05-23 | MSV000079757 | MassIVE
ProteomicsUse of a modified Multiplexed Inhibitor Bead assay to study kinome responses to cytostatic treatment in human cancer cell lines Triplicate Test: pilot study
In order to improve elution of proteins from the column, to reduce the cost as well as the hands on time of the analysis, we here present a modification of the Multiplexed Inhibitor Bead assay (MIB assay), where we elute the proteins from beads containing covalently bound inhibitors using trypsin di...
ORGANISM(S): Homo sapiens (Human) 
2017-02-13 | PXD005402 | Pride
Ms Test Triplicate 
ProteomicsCpFTSY mediates co-translational insertion of thylakoid membrane proteins in diatoms, modulating their photosynthetic performances.
CpFTSY is a component of the chloroplast signal recognition particle (CpSRP) pathway that post-translationally targets light-harvesting complex proteins (LHCPs) to the photosynthetic (thylakoid) membranes in plants and green algae containing chloroplasts derived from primary endosymbiosis. In plants...
ORGANISM(S): Phaeodactylum tricornutum (strain CCAP 1055/1) 
2023-07-20 | PXD031340 | Pride
Cpftsy mediates co-translational insertion of thylakoid membrane proteins in diatoms Modulating their photosynthetic performances. 
Sort   by:  
 Page size