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ProteomicsDifferential protein expression between Carfilzomib-sensitive (AMO1) and resistant (AMO1-CFZ) multiple myeloma cells
Carfilzomib-sensitive (AMO1) and resistant (AMO1-CFZ) MM cells were grown in RPMI-1640 medium supplemented with 10 % FBS and 0.68 mM L-glutamine, in a humidified incubator at 5% CO2 and 37 °C. The AMO1-CFZ medium was additionally added 90 nM CFZ, while the CFZ sensitive AMO1 cells were added vehicle...
ORGANISM(S): Homo sapiens (Human) 
2024-06-07 | PXD045439 | Pride
Myeloma 
UnknownUracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms.
Not available
S-EPMC1919486 | biostudies-literature
ProteomicsIdentification of adsorbing human plasma proteins on alginate gel beads
The biocompatibility of immunoisolation devices is a major challenge for their use in cellular therapies. Utilisation of alginate for the encapsulation of pancreatic islets as a potential cellular therapy for type 1 diabetes has shown to be limited in terms of long-term graft survival, due to perica...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD009135 | Pride
Alginate gel beads Biocompatibility Protein adsorption Proteomics 
ProteomicsProteomic analysis uncovers enhanced inflammatory pheno-type and distinct metabolic changes in IDH1 mutant glioma cells
Isocitrate dehydrogenase 1 (IDH1) mutations are key drivers of glioma biology, influenc-ing tumor aggressiveness and treatment response. To elucidate their molecular impact, we performed proteome analysis on patient-derived (PD) and U87MG glioma cell models with either mutant or wildtype IDH1. We qu...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD065327 | Pride
Dna repair Antigen presentation Glioma biomarkers Isocitrate dehydrogenase mutations Rna Dna and histone demethylases Proteomics Interferon signaling 
ProteomicsHistone deacetylase inhibitors mediate selective degradation of nuclear uracil-DNA glycosylase 2 and increased genomic uracil
HDAC inhibitors (HDACi) belong to a new group of chemotherapeutics that are increasingly used to treat B-cell-derived malignancies. Such malignancies regularly carry mutational signatures that conform to off-target induction of uracil by the AID/APOBEC family of cytidine deaminases, or downstream pr...
ORGANISM(S): Homo sapiens (Human) 
2020-04-14 | PXD008293 | Pride
Aa Amino acid  aid Activation induced deaminase; 
ProteomicsOxidative posttranslational modifications of cysteine are associated to high intrinsic aerobic capacity in the skeletal and cardiac muscle
Oxidative posttranslational modifications (Ox-PTMs) regulate cellular homeostasis in several tissues, including skeletal and cardiac muscles. The putative relationship between Ox-PTMs and intrinsic components of oxidative energy metabolism has not been previously described. We determined the metabol...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-11-12 | PXD009109 | Pride
Heart Ox-ptm Mdh1 Redox proteomics Exercise Icat Mitochondria Cysteine Cardiac Aerobic Skeleta Oxidation Oxidative stress Posttranslational modifications Muscle 
ProteomicsOff-target responses in the HeLa proteome subsequent to transient plasmid transfection using SILAC
We report a significant differential expression of proteins, all of which are associated with a viral infection response typified by Interferon type I/II. Notably the upregulated proteins may affect several vital cellular processes, including cell cycle control, translation and post-translational m...
ORGANISM(S): Homo sapiens (Human) 
2014-12-08 | PXD001278 | Pride
Hela Proteome Plasmid Transfection Silac Off-target Responses Transient 
UnknownType 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences.
Not available
S-EPMC12318296 | biostudies-literature
UnknownMS-proteomics provides insight into the host responses towards alginate microspheres.
Not available
S-EPMC9676213 | biostudies-literature
UnknownUNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.
Not available
S-EPMC3201877 | biostudies-literature
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