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ProteomicsA nowhere-to-hide mechanism ensures complete piRNA-directed LINE1 methylation
The mouse PIWI-interacting RNA (piRNA) pathway provides anti-transposon immunity to the developing male germline by directing transposon DNA methylation. The first step in this process is the recruitment of SPOCD1 to young LINE1 loci 1 followed in the second step by piRNA-mediated tethering of the P...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-11 | PXD060851 | Pride
Piwi proteins Pirna Spocd1 and tpr Germline Transposons 
ProteomicsA nowhere-to-hide mechanism ensures complete piRNA-directed LINE1 methylation
The mouse PIWI-interacting RNA (piRNA) pathway provides anti-transposon immunity to the developing male germline by directing transposon DNA methylation. The first step in this process is the recruitment of SPOCD1 to young LINE1 loci 1 followed in the second step by piRNA-mediated tethering of the P...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-11 | PXD060850 | Pride
Piwi proteins Pirna Spocd1 and tpr Germline Transposons 
ProteomicsDysfunction of a SET3C-like complex underlies a family of related neurological disorders
TBLR1, a subunit of the NCoR corepressor complex, is mutated in a range of neurodevelopmental disorders that only partially align symptomatically with those caused by mutations in its binding partner, MeCP2. In a search for novel TBLR1-binding partners, we identified ANKRD11 and SETD5 – mutations in...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-01 | PXD063846 | Pride
Human Tblr1 Neurological disorders Ankrd11 Setd5 Set3c 
ProteomicsDysfunction of a SET3C-like complex underlies a family of related neurological disorders
TBLR1, a subunit of the NCoR corepressor complex, is mutated in a range of neurodevelopmental disorders that only partially align symptomatically with those caused by mutations in its binding partner, MeCP2. In a search for novel TBLR1-binding partners, we identified ANKRD11 and SETD5 – mutations in...
ORGANISM(S): Homo sapiens (Human) 
2026-05-01 | PXD077916 | Pride
Dia. Tblr1 Mecp2 Set3c-like complex Ankrd11 Setd5 Neurodevelopmental disorders Dda 
ProteomicsHepatic dysregulation of glyoxalase 1 in preclinical models and patients with non-alcoholic fatty liver disease
Background & Aims: Although non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, aspects of its molecular pathogenesis are unknown and clinical biomarkers for early diagnosis and accurate disease staging remain scarce. The aims of these experiments were to identify...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-16 | PXD001442 | Pride
Quantitative proteomics Glyoxalase Mouse Q-tof Nlc-ms/ms Liver Itraq 
ProteomicsRoles of SNORD115 and SNORD116 ncRNA clusters in neuronal differentiation
Prader-Willi syndrome shows features linked to brain development and hypothalamus-related endocrine abnormalities. The smallest clinical deletions fall within the large (∼650Kb) SNHG14 gene, removing 29 consecutive introns that each generate SNORD116. SNHG14 also includes 48 tandem introns encoding ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-15 | PXD057208 | Pride
Small nucleolar rnas Dia Prader-willi syndrome Snord116 Snord115 
ProteomicsNucleosome interaction of the CPC secures centromeric chromatin integrity and chromosome segregation fidelity
The chromosomal passenger complex (CPC; Borealin-Survivin-INCENP-Aurora B kinase) ensures accurate chromosome segregation by orchestrating sister chromatid cohesion, error-correction of kinetochore-microtubule attachments and spindle assembly checkpoint. Correct spatiotemporal regulation of CPC loca...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD068775 | Pride
ProteomicsUbiquitinated proteins in Arabidopsis thaliana leaf tissue infected with Pseudomonas syringae
Ubiquitin signalling plays an indispensable role in plant immune signalling. Pathogen infection leads to rapid increases in the ubiquitinated proteome. Here, we identified ubiquitinated proteins and ubiquitination sites in Arabidopsis thaliana leaf tissue infected with the virulent pathogen Pseudomo...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-02-12 | PXD074126 | Pride
Arabidopsis thaliana Pseudomonas syringae Plant infection Lumos Ubiquitin Dda 
ProteomicsDICER1 syndrome-associated mutations lead to 3p-miRNA gain of function and increased metastatic potential
The DICER1 gene is mutated in cancer, including Dicer1 syndrome, a rare tumour predisposition syndrome. Cancer-associated hotspots mutations have been reported in both catalytic domains of Dicer, and are predicted to disrupt miRNA processing activity. To understand these hotspot mutations in cancer ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-23 | PXD072167 | Pride
Cancer Dia Dicer1 Mutations Exploris480 
ProteomicsDefining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins
Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology differ significantly from other eukaryotic model systems, including yeasts, plants, worms, flies and...
ORGANISM(S): Trypanosoma brucei 
2026-03-01 | PXD063130 | Pride
Kinetochore Chromatin-associated proteins Trypanosoma brucei brucei Repetitive elements 
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