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ProteomicsValidation of a high-performance liquid chromatography-tandem mass spectrometry immunopeptidomics assay for the identification of HLA ligands suitable for pharmaceutical therapies
For more than two decades naturally presented, human leukocyte antigen (HLA)-restricted peptides (immunopeptidome) have been eluted and sequenced using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Since, identified disease-associated HLA ligands have been characterized and evaluated as...
ORGANISM(S): Homo sapiens (Human) 
2020-01-15 | PXD012797 | Pride
Validation Mass spectrometry Gmp Cancer immunotherapy Immunopeptidome Lc–ms/ms 
ProteomicsChicken MHC class II presented Marek's disease virus (MDV) and infectious bursal disease virus (IBDV) antigenic peptides
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer...
ORGANISM(S): Gallus gallus (Chicken) 
2021-09-10 | PXD023954 | Pride
Mdv Chicken mhc Immunopeptidomics Mhc class ii Ibdv Mhc class i 
ProteomicsImpact of CD74 knockdown on the HLA peptidome of the H1 melanoma cell line
The influence of CD74 expression on the HLA peptidome of the H1 melanoma cell line was analyzed by label-free quantitation mass spectrometry of HLA ligand extracts obtained from CD74 siRNA & control siRNA treated cells.
ORGANISM(S): Homo sapiens (Human) 
2018-03-01 | PXD008937 | Pride
Hla peptidome Melanoma Cd74 
ProteomicsUnveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
The classical HLA-C and the nonclassical HLA-E and HLA-G molecules play important roles both in the innate and adaptive immune system. Starting already during embryogenesis and continuing throughout our lives, these three Ags exert major functions in immune tolerance, defense against infections, and...
ORGANISM(S): Homo sapiens (Human) 
2018-04-20 | PXD009531 | Pride
Hla-e Hla-g Binding prediction  peptide motifs Hla-c Lc-msms 
ProteomicsMHC-I peptidome analysis of human foreskin fibroblasts
Ribosome profiling (Ribo-seq) recently revealed the expression of thousands of short open reading frames (sORFs) in eukaryotic cells. They encode for a class of instable peptides, which evade experimental validation by whole-proteome mass spectrometry. Here, we show that computational elimination of...
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD007203 | Pride
Human Hff Peptidome Mhc-i 
ProteomicsHLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis
Autoimmune diseases are often associated with HLA molecules. Multiple sclerosis (MS) is a prototypical example with the HLA-DR15 haplotype as strongest genetic factor. How it contributes to MS is not clear, but key to understand this and other autoimmune diseases. Autoreactive CD4+ T cells and proin...
ORGANISM(S): Homo sapiens (Human) 
2020-10-22 | PXD015249 | Pride
Multiple sclerosis Hla cross-restriction Immunopeptidome B cells Hla-dr-derived self-peptides Cross-reactivity Hla-dr15 molecules Autoreactive cd4+ t cells 
ProteomicsIdentification of changes in the LNZ308 HLA immunopeptidome after virotherapy, irradiation and chemotherapy
Glioblastoma is an aggressive incurable primary malignant brain tumor. Measles virus (MeV) therapy is a promising upcoming treatment strategy with proven preclinical efficacy and clinical safety. Using RNA Sequencing and immunopeptidome analyses, we aimed at identifying a synergistic combination reg...
ORGANISM(S): Homo sapiens (Human) 
2018-02-19 | PXD008984 | Pride
Human Oncolytic virotherapy Glioblastoma Lcms Personalized immunotherapy Immunopeptidome 
TranscriptomicsHLA ligand profiles of primary renal cell carcinoma maintained in metastases.sue
In recent years, several approaches have been taken in the peptide-based immunotherapy of metastatic renal cell carcinoma (RCC), although little is known about HLA presentation on metastases compared to primary tumor and normal tissue of RCC. In this study we compared primary tumor, normal tissue an...
ORGANISM(S): Homo sapiens 
2008-09-03 | E-GEOD-12606 | biostudies-arrayexpress
UnknownHLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis.
Not available
S-EPMC7707104 | biostudies-literature
ProteomicsDigital mapping of immunopeptidomes
We present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-04 | MSV000079623 | MassIVE
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