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ProteomicsFkbp5 Gene Deletion: Impacts on Circadian Rhythmicity and Brain Proteomics in Aged Mice
FKBP51, also known as FK506-binding protein 51, is a molecular chaperone and scaffolding protein with significant roles in regulating hormone signaling and stress responding. Genetic variants in FKBP5, which encodes FKBP51, have been implicated in a growing number of neuropsychiatric disorders, whic...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-05 | PXD049439 | Pride
Knock out Brain Hippocampus Dia Ko Prm Aged Amygdala Mouse Fkbp5 
ProteomicsA semi-automated workflow for DIA-based global discovery to pathway-driven PRM analysis
Initial discovery-based analysis using data independent acquisition (DIA) can obtain deep proteome coverage with high data completeness; however, the development of targeted PRM assays based on subsequent bioinformatic predictions can be tedious and time-consuming because of the complexity of the ou...
ORGANISM(S): Homo sapiens (Human) 
2024-09-06 | PXD049405 | Pride
Dia Timstof Script Bruker Sem-automated Prm 
ProteomicsDeregulated Expression of the 14q32 miRNA Cluster in Clear Cell Renal Cell Carcinomas
Clear cell renal cell carcinomas (ccRCC) are characterized by arm-wide chromosomal alterations. Loss at 14q is associated with disease aggressiveness in ccRCC, which responds poorly to chemotherapeutics. The 14q locus contains one of the largest miRNA clusters in the human genome; however, little is...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD036428 | Pride
Lpa Dia Q-tof Claudin-1 14q32 Iron Dnmt1 Timstof pro Ccrcc Atxn2 
ProteomicsProteome Dataset for Adult-derived Mouse Microglia
We report methods development for quantitative proteomic analysis of samples with limited number of cells. The improvements include suspension trapping (S-Trap) for sample processing, longer analytical column length (75cm), and a segmented data dependent acquisition approach. The modified approach w...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-18 | PXD012006 | Pride
Neuroinflammation Img cells Proteomics Mass spectrometry Microglia Dataset brief Glia 
ProteomicsProteomic characterization of the Alzheimer’s disease risk factor BIN1 interactome
The gene BIN1 is the second-largest genetic risk factor for late-onset Alzheimer’s disease (LOAD). BIN1 is expressed in neurons and glia in the brain as multiple isoforms, including neuron-specific and ubiquitously expressed isoforms. BIN1 is an adaptor protein that regulates membrane dynamics in ma...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-22 | PXD060638 | Pride
Phospho proteomics Bridging integrator 1 (bin1) Mouse Late onset alzheimer’s disease (load) Interactome 
ProteomicsIntegrated Multi-Omic Analysis Reveals KDM5B as a Regulator of Microglial Reactivity to Immunomodulatory Stimuli
Microglia maintain brain homeostasis through coordinated pathways, including cell migration, phagocytosis, and secretion of immune-related signaling factors. Microglial reactivity is associated with a variety of functional outcomes that are highly context-dependent with epigenetic regulation through...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-02 | PXD058485 | Pride
ProteomicsDevelopment and evaluation of a SILAC method for proteomic analysis of rat primary microglia
Microglia play important and dynamic roles in mediating a variety of physiological and pathological processes during the development, normal function, and degeneration of the central nervous system. We report here the development of a SILAC-labeled model system suitable for mass spectrometry-based ...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-04-07 | PXD002759 | Pride
Rat Silac Microglia Primary 
ProteomicsGlobal Proteomic Profiling in Chronic Iron-Exposed Fallopian Tube Secretory Epithelial Cells
We previously published (Oncogenesis, Rockfield et al., 2019) that chronic iron exposure (with ferric ammonium citrate, FAC) in immortalized fallopian tube secretory epithelial cells resulted in increased growth and migratory propensity. Our focused analyses identified a subset of oncogenic markers,...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018416 | Pride
Initiation events Ovarian cancer Proteomic profiling Fallopian tube secretory epithelial cells Ferric ammonium citrate 
ProteomicsCharacterization of phosphohistidine phosphatase 1-induced changes in the mouse liver proteome
Phosphohistidine signaling in mammalian biological systems has not been well characterized. In this study, we investigated the impact of phosphohistidine phosphatase 1 (PHPT1) expression on the hepatic proteome profile in vivo. PHPT1 overexpression was carried out using adenoviral-based transgene de...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-29 | PXD008323 | Pride
Mus musculus Phosphohistidine Hepatic proteomics Phpt1 
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_LPS_1, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320019104 | GPMDB
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