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ProteomicsEffects of CerS4 deletion in murine epidermis on proteome and lipidome
Epidermal deletion of the lipid modifying enzyme CerS4 causes epidermal barrier impairments associated with human skin diseases. Proteomes of Wt newborn and P47 mice were compared in order to identify molecular differences between barrier formation and maintenance. Proteomes of epidermal splits from...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-27 | PXD012220 | Pride
Epidermal barrier Lipid homeostasis Barrier maintenance Barrier formation Cers4 Ceramides 
ProteomicsProteomics of Galápagos marine iguanas links function of femoral gland proteins to the immune system
Communication between individuals via molecules, termed chemosignaling, is widespread among animal and plant species. However, we lack knowledge on the specific functions of the substances involved for most of such systems. The femoral gland is an organ secreting a waxy substance, which is involved ...
ORGANISM(S): Amblyrhynchus cristatus 
2020-06-29 | PXD018909 | Pride
Iguana proteomics galapagos femoral gland immune 
ProteomicsNerve activity inhibits mTORC1-dependent protein synthesis in skeletal muscle
To find out intracellular signaling pathways regulting fiber type specific muscle wasting we generated a new mouse model, which allows us to label specifically muscle proteins. Interestingly, we observed that loss of muscle activity by denervation induces a strong increase of protein labeling in oxi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056544 | Pride
Skeletal muscle Mtorc1 Protein synthesis 
ProteomicsDetection of putative PKA target phosphorylation sites in Atg5flox:CamKII-Cre wildtype and knockout mice brain tissue
The experiment was performed to identify PKA phosphorylation substrates in wildtype and autophagy-deficient brains. Therefore, hippocampus and cortex of wildtype and conditional knockout mice were isolated and sliced. The brain slices were incubated with DMSO or Forskolin, a cAMP elevating agent, to...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-15 | PXD031106 | Pride
Forskolin Autophagy-deficiency Brain slices Pka signalling 
ProteomicsProteome and phosphoproteome analysis of autophagy deficient ATG5flox:CamKII-Cre and ATG5flox:VGAT-Cre conditional knockout mice
The experiment was performed to find selective targets of autophagy in different subtypes of neurons. Therefore, brain tissue of conditional knockout mice lacking autophagy protein ATG5 in inhibitory or excitatory neurons was used. Cortices (ATG5flox:CamKII-Cre) / striata (ATG5flox:VGAT-Cre) of mice...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-15 | PXD029435 | Pride
Atg5 Neurons Autophagy Brain 
ProteomicsRaptor and rapamycin dependent proteomic changes in Akt overexpressing skeletal muscle
Analysis of proteomic changes upon deletion of Raptor or inhibition by rapamycin in mouse muscles over expressing a constitutively active Akt.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-08 | PXD028796 | Pride
Akt Raptor Skeletal muscle Mtor 
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