Sort   by:  
 Page size 
ProteomicsThe role of testosterone in spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency
Testosterone is essential to maintain qualitative spermatogenesis. Nonetheless, no studies have been yet performed in humans to analyze the testosterone-mediated expression of the sperm proteins and their importance in reproduction. Thus, this study aimed to identify sperm protein alterations in mal...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD032270 | Pride
Proteomics Hypogonadism Tmt Lh deficiency Male infertility Sperm Testosterone 
TranscriptomicsTranscription profiling of human breast cancer cell lines treated with testosterone and testosterone-BSA conjugate
The role of androgen in breast cancer development is not fully understood although androgen receptors (AR) have been identified in breast cancer clinical samples and cell lines. However the whole spectra of androgen actions cannot be accounted to the classic AR mode of action and the possible existe...
ORGANISM(S): Homo sapiens 
2009-11-16 | E-GEOD-18146 | biostudies-arrayexpress
ProteomicsA pilot proteomic study reveals different protein profiles related to testosterone and gonadotropin changes in a short-term controlled healthy human cohort
Testosterone deficiency afflicts approximately 30% of men aged from 40-89 years. It is associated with type 2 diabetes, metabolic syndrome and cardiovascular disease. However, the causality of the relationship between low testosterone and metabolic diseases is unclear. We have analysed plasma sampl...
ORGANISM(S): Homo sapiens (Human) 
2020-08-03 | PXD016096 | Pride
Testosterone Mass spectrometry Proteomcis 
TranscriptomicsTranscription profiling of human skeletal muscle from Hiv-Infected Men experiencing weight loss treated with testosterone
Context: Although androgen treatment increases muscle mass in HIV-infected men, the underlying mechanisms are poorly understood. Analysis of genome-wide microarray data obtained from skeletal muscle biopsies can be used to profile androgen-regulated pathways. Objective: To identify genes and pathway...
ORGANISM(S): Homo sapiens 
2009-04-10 | E-GEOD-5106 | biostudies-arrayexpress
TranscriptomicsLeptin dependent control of testosterone regulated hepatic lipid metabolism
Population based studies have established that androgen deficiency in males correlates with type 2 diabetes, visceral adiposity, and metabolic syndrome. Androgen therapy has been investigated as a possible treatment regime to combat these disorders. However, the molecular mechanism of androgen effec...
ORGANISM(S): Rattus norvegicus 
2012-09-02 | E-GEOD-23941 | biostudies-arrayexpress
ProteomicsIdentifying a novel hydroxysteroid dehydrogenase enzyme that is capable of testosterone biosynthesis in the mouse
Androgens, such as testosterone and dihydrotestosterone (DHT), are essential for male sexual development, masculinisation, spermatogenesis, and general lifelong health. Androgens are predominantly synthesised in the testes of mice (~95%) by highly specialised cells known as the Leydig cells. There a...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD050748 | Pride
Androgens Alternate pathway Hsd17b7 Canonical pathway Testosterone Srd5a1 Testosterone biosynthesis Hsd17b3 
TranscriptomicsTranscription profiling of rat gastrocnemius muscles from male animals to assess the effects of testosterone on dexamethasone-induced changes in gene expression
Glucocorticoids are a well recognized and common cause of muscle atrophy. Glucocorticoid-induced atrophy can be prevented by testosterone, but the molecular mechanisms underlying such protection have not been described. Thus, the global effects of testosterone on dexamethasone-induced changes in ge...
ORGANISM(S): Rattus norvegicus 
2009-07-11 | E-GEOD-12296 | biostudies-arrayexpress
TranscriptomicsTestosterone- and estrogen-induced genes in urogenital sinus mesenchyme
The goal of this experiment was to determine if testosterone (T) and estradiol-17 beta (E2) induced gene expression in mouse urogenital sinus mesenchymal (UGM) cells. When UGM grown in culture was treated with T+E2, numerous genes were increased and decreased compared to untreated controls. Quantita...
ORGANISM(S): Mus musculus 
2012-04-26 | E-GEOD-37620 | biostudies-arrayexpress
TranscriptomicsComplex modulation of androgen responsive gene expression by methoxyacetic acid
Optimal androgen signaling is critical for testicular development and spermatogenesis. Methoxyacetic acid (MAA), the primary active metabolite of the industrial chemical ethylene glycol monomethyl ether, disrupts spermatogenesis and causes testicular atrophy. Transcriptional trans-activation studi...
ORGANISM(S): Mus musculus 
2011-04-07 | E-GEOD-27410 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung adenocarcinoma derived cell line A549 treated with testosterone
Effect of testosterone treatment on gene expression of lung adenocarcinoma derived cell line A549
ORGANISM(S): Homo sapiens 
2010-01-05 | E-MEXP-2003 | biostudies-arrayexpress
Sort   by:  
 Page size