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Proteomics20 human soft-tissue sarcomas (TMT)
SCX fractiond, TMT labeled pleomorphic soft-tissue sarcomas. 32 raw files (8x4) plus 8 pools (also TMT labeled) corresponding to each SCX fraction are submitted. The latter were used to propagate identifications across the runs.
ORGANISM(S): Homo sapiens (Human) 
2020-01-27 | PXD000617 | Pride
Tmt human sarcoma 
ProteomicsA comprehensive evaluation of the Ewing sarcoma surface and global proteomes reveals actionable immunotherapeutic targets.
Ewing sarcoma (EwS) is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. While the survival rate of patients diagnosed with localized disease is ~70%, this decreases to ~30% for patients with metastatic disease and only ~10% for treatment refractory d...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD043375 | Pride
Ewing sarcoma Surfaceome 
ProteomicsDiscovery-Based Protein Expression Profiling Identifies Distinct Subgroups and Pathways in Leiomyosarcomas
20 tumor samples run in duplicates, consisting of pleomorphic sarcomas; classfied as leiomyosarcoma or high-grade undifferentiated pleomorphic sarcoma.
ORGANISM(S): Homo sapiens (Human) 
2020-01-27 | PXD000616 | Pride
Sarcoma human label-free 
ProteomicsProteomics Analysis of Human Mesenchymal Stromal/Stem Cell Sarcomagenesis Model Identifies ALDH1A3 and CD99 as Potential Targets in the Transformation Process
Mesenchymal stromal/stem cells (MSC) may represent the cell-of-origin for sarcoma development. A collection of human MSCs sequentially mutated with an increasing number of oncogenic hits served to recreate a step-wise process of sarcomagenesis. To identify potential protein targets of interest in th...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069892 | Pride
Msc-sarcoma model Sarcomagenesis Cd99 Proteomics (lc-ms/ms) Aldh1a3 
ProteomicsIL1RAP augments cysteine metabolism to promote ferroptosis resistance and metastasis in Ewing sarcoma
Aggressive cancer cells must adapt and overcome oxidative stress encountered during the metastatic cascade to successfully disseminate. In this work, a combination of proteomic approaches is used to identify the IL1 receptor accessory protein (IL1RAP) as an in vitro suppressor of anoikis (detachment...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-05-25 | PXD019009 | Pride
Tmt Cysteine metabolism Il1rap Ewing sarcoma 
ProteomicsUSP1 expression driven by EWS-FLI1 transcription factor stabilizes Survivin and promotes Ewing sarcoma cell survival
Ewing sarcoma (EWS) is a malignant pediatric bone cancer. Most Ewing sarcomas are driven by EWS-FLI1 oncogenic transcription factor that plays roles in transcriptional regulation, DNA damage response, cell cycle checkpoint control, and alternative splicing. USP1, a deubiquitylase which regulates DNA...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041033 | Pride
Ews-fli1 Usp1 Survivin 
ProteomicsHuman Cardiac Proteome of Hypertrophic Cardiomyopathy
This study utilized TMT to characterize the cardiac proteomic differences between patients with hypertrophic cardiomyopathy and controls.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-28 | MSV000091821 | MassIVE
ProteomicsHuman hypertrophic cardiomyopathy cardiac tissue phosphoproteomics
This study used TMT-pro method to look for phosphoproteomic differences in heart tissue of patients with hypertrophic cardiomyopathy and controls
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-04-28 | MSV000091822 | MassIVE
ProteomicsMolecular Profiling Defines Three Subtypes of Synovial Sarcoma
Synovial Sarcomas (SS) are characterized by the presence of the SS18::SSX fusion gene, which protein product induce chromatin changes through remodeling of the BAF complex (BRG1/BRM-associated factor complex), which leads to widespread alterations in gene expression that drive tumor development and ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053789 | Pride
Synovial sarcoma  transcriptomics  multi-omic  molecular subtypes  proteomics 
ProteomicsQuantitative proteomics analysis of lytic KSHV infection in human endothelial cells reveals novel targets of viral immune modulation
Kaposi’s Sarcoma associated herpesvirus (KSHV) is an oncogenic human virus and leading cause of mortality in HIV infection. Reactivation of KSHV from latent to lytic stage infection initiates a cascade of viral gene expression, and here we show how these changes remodel the host cell proteome to ena...
ORGANISM(S): Homo sapiens (Human) Human herpesvirus 8 strain rKSHV.219 
2022-05-26 | PXD017365 | Pride
Proteomics Kshv Immune modulation 
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