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ProteomicsMulti-omics profiling of non-small cell lung cancer patient-derived xenografts reveals proteome and phosphoproteome remodeling associated with patient outcome
131 patient-derived xenograft models were generated for non-small cell lung carcinoma and were profiled at the genome, transcriptome and proteome level by analysis of gene copy number variation, whole exome sequencing, DNA methylation, transcriptome, proteome and phospho(Tyr)-proteome. At the proteo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-24 | PXD016674 | Pride
Human Nsclc Phosphorylation Pdx Tyrosine Proteome 
OtherProteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.
Data from ProteomeXchange, PXD ID: PXD000788. File: T1041A_Cont3.mzml. Published as part of Mol Cell Proteomics. 2014 Jul;13(7):1644-58 . From the Abstract: {{i}} ass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and protein-protein interactions of wild ty...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310004705 | GPMDB
Resource Reanalysis 
ProteomicsProfiling of human lung tissues on 11 normal control, 11 patient and 11 corresponding mouse xenograft tumours
The total protein expression level of 11 paired human normal, human lung cancer samples and correspoding mouse xenograft samples were analyzed by LC-MS/MS. These protein expression data were than compared with corresponding DNA copy number changes and mRNA expression level changes among these sampl...
ORGANISM(S): Homo sapiens (Human) 
2014-12-04 | PXD000853 | Pride
Proteomics Mouse xenograft Human lung tumor 
ProteomicsThe deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival
USP7, as a deubiquitination enzyme, controls ubiquitination and stability of Maf family proteins. USP7 promotes Maf transcriptional activity. Moreover, USP7 is overexpressed in multiple myeloma cells and its expression level is negatively correlated to the survival of myeloma patients.
ORGANISM(S): Homo sapiens (Human) 
2019-12-16 | PXD016020 | Pride
Usp7 Myeloma Deubiquitinase Maf 
ProteomicsHuman EGFR AP-MS project - Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress
Mass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and interactome of wild type and endocytosis-defective EGFR variants before and after internalization in response to EGF or stress.
ORGANISM(S): Homo sapiens (Human) 
2014-10-23 | PXD000788 | Pride
Ptm Immunoprecipitation Egfr Lc-ms/ms 
ProteomicsAML_profiling - Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome and tyrosine-phosphatome in acute myeloid leukemia
LC-MS/MS was used to profile total phosphotyrosine phosphatase in acute myeloid leukemia (AML) in order to find potential biomarkers, drug targets, signatures for AML classification, and its relationship with total phosphotyrosine amount in the samples.
ORGANISM(S): Homo sapiens (Human) 
2017-02-16 | PXD001170 | Pride
Pyome Ptpome Acute myeloid leukemia Proteome Aml Lc-ms/ms 
ProteomicsCancer proteome and metabolite changes linked to SHMT2
To screen for proximate and interacting proteins of SHMT2 in HeLa cells, the BioID method was employed, which consists of biotinylation of proteins in the vicinity of FlagBirAR118G –SHMT2 followed by streptavidin-based affinity capture and mass spectrometry identification. Experimental procedures we...
ORGANISM(S): Homo sapiens (Human) 
2020-08-12 | PXD004629 | Pride
Streptavidin Shmt2 Ms Bioid 
ProteomicsLung_pY profiling - Profiling phospho-tyrosine levels in mosue tumors which were xenografted from pateint lung tumor.
Profiling phospho-tyrosine levels in mosue tumors which were xenografted from pateint lung tumor.
ORGANISM(S): Homo sapiens (Human) 
2018-09-07 | PXD000809 | Pride
Py profiling Lung Ptm Xenograft Lc-ms/ms 
ProteomicsHuman EGFR AP-MS project
Mass spectrometry was applied to comprehensively analyze the phosphorylation, ubiquitination, and interactome of wild type and endocytosis-defective EGFR variants before and after internalization in response to EGF or stress.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-23 | MSV000079525 | MassIVE
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