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ProteomicsBenchmarking the Orbitrap Tribrid Eclipse for Next Generation Multiplexed Proteomics
The rise of sample multiplexing in quantitative proteomics for the dissection of complex phenotypic comparisons has been advanced by the development of ever more sensitive and robust instrumentation. Here, we evaluated the utility of the Orbitrap Eclipse Tribrid mass spectrometer (advanced quadrupol...
ORGANISM(S): Homo sapiens (Human) 
2022-01-07 | PXD016766 | Pride
Real-time search Quantitative proteomics Eclipse Turbotmt Precursor fit filter Tmt Orbitrap Instrumentation 
UnknownBenchmarking the Orbitrap Tribrid Eclipse for Next Generation Multiplexed Proteomics.
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S-EPMC7295122 | biostudies-literature
ProteomicsIntegrated Proteomics and Machine Learning Reveal AHNAK as a Discriminative Biomarker of Atrial Fibrillation in Heart Failure
Plasma proteins were digested with trypsin and the resulting peptides were analyzed by nanoLC–MS/MS on an EASY-nLC 1200 system coupled to an Orbitrap Exploris 480 mass spectrometer. Peptides were loaded onto a self-packed C18 reversed-phase column (25 cm × 100 μm i.d.) and separated at 500 nL/min us...
ORGANISM(S): Homo sapiens (Human) 
2026-06-21 | PXD073684 | Pride
Atrial fibrillation Heart failure Ahnak protein Biomarkers Atrial fibrosis 
ProteomicsInvestigating HMGB1 as a Potential Serum Biomarker for Early Diabetic Nephropathy Monitoring by Quantitative Proteomics
Current diagnostic methods for diabetic nephropathy (DN) lack precision, especially in early stages and monitoring progression. This study aims to find potential biomarkers for DN progression and evaluate their accuracy. Using serum samples from healthy controls (NC), diabetic patients (DM), early-m...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD047872 | Pride
Diabetic nephropathy  serum proteomics  biomarker  progression  high mobility group protein b1 
ProteomicsccRCC cells treated with DMSO or UNC8209
Clear cell renal cell carcinoma (ccRCC), the most common kidney cancer subtype, often features inactivation of the VHL tumor suppressor, creating therapeutic vulnerabilities. Although HIF2α inhibitors have shown promise, many VHL-deficient tumors remain resistant. TANK-binding kinase 1 (TBK1) has be...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD071969 | Pride
Lc-msms Protac Tbk1 Ccrcc 
ProteomicsSex Differences in Response to Glutathione Precursors in the Aging Heart
Diastolic dysfunction in the aged population is multifactorial. Common features of the aging heart are dysregulated metabolism, elevated oxidative stress, inflammation and fibrosis, where each of these conditions can linked together and further promote the altered phenotype. It becomes increasingly ...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-05 | PXD048895 | Pride
Heart Sex differences Mitochondria Aging Extracellular matrix 
Proteomics(LCMS)/MS studies of prefrontal cortex synaptosomal fractions in Eef2 HET mice - eEF2 in the prefrontal cortex regulates excitatory synaptic transmission and social novelty behavior.
To investigate the protein expression changes at the synapse induced by Eef2 reduction, we performed (LCMS)/MS-based proteomic analysis in crude synaptosome preparations from the PFC of WT and Eef2 HET mice.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-15 | PXD034864 | Pride
Prefrontal cortex (lcms)/ms Synaptosome Eef2 
ProteomicsEndo-IP and Lyso-IP Toolkit for Endolysosomal Profiling of Human Induced Neurons
We developed a toolkit for capturing endosomes (Endo-IP) and lysosomes (Lyso-IP) in human stem cell(hESC)-derived induced neurons (iNeurons). We target a sub-population of early endosomes marked by endogenously tagged EEA1 (Early Endosome Antigen 1) protein, which represents one of the earliest popu...
ORGANISM(S): Homo sapiens (Human) 
2025-01-11 | PXD055978 | Pride
Human Tmt Endosomes Ineurons Lysosomes 
ProteomicsThe Role of FASN in bladder cancer
To dissect the mechanistic interplay between fatty acid metabolism and cigarette smoke–induced signaling in bladder cancer, we employed a proteomics analysis xenograft tumors derived from the UMUC3 with either stable FASN knockdown (KD) or control shRNA, with and without cigarette smoke. We performe...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-06-15 | PXD068785 | Pride
Proteomics Fasn Cigarette smoke Bladder cancer 
ProteomicsHuman clear cell renal cell carcinoma ZMYND8 ubiquitination
Mass spectrometry of potential ubiquitination sites in ZMYND8 under SPOP overexpression condition
ORGANISM(S): Homo sapiens (Human) 
2026-05-28 | PXD058853 | Pride
Ubiquitination Zmynd8 
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