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ProteomicsE2~dID: A versatile approach to identify substrates modified with ubiquitin and ubiquitin-like molecules by specific E3 enzymes
Covalent modifications of proteins with ubiquitin and ubiquitin-like molecules are instrumental to most, if not all biological processes. However, identifying the E3 ligase responsible for these modifications remains a major bottleneck in ubiquitin research. Here, we have developed an E2-thioester-d...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2019-04-03 | PXD008624 | Pride
Ubiquitin Ap-ms Tmt 
ProteomicsMolecular signatures after challenge with Salmonella Typhi implicate host tryptophan metabolism in the pathogenesis of typhoid fever, part 1
Induced pluripotent stem (iPS) cell derived human macrophages were stimulated with IFN-y or exposed to viable S. Typhimurium SL1344 using either a gentamicin invasion assay or after over-night priming with IFN-y. Protein abundance changes between samples was determined relative to unstimulated contr...
ORGANISM(S): Homo sapiens (Human) 
2016-05-31 | PXD001953 | Pride
Human Macrophages Salmonella typhi Tmt Ips 
ProteomicsDIPG harbour alterations targetable by MEK inhibitors, with acquired resistance mechanisms overcome by combinatorial inhibition
The survival of children with DIPG remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment failure. In a prospective biopsy-stra...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD019701 | Pride
Lc-msms Tmt Clinical Dipg 
ProteomicsMolecular signatures after challenge with Salmonella Typhi implicate host tryptophan metabolism in the pathogenesis of typhoid fever, part 2
Label free quantitation using DIA HDMSe of Salmonella infected and uninfected mouse caecum tissue
ORGANISM(S): Mus musculus (Mouse) 
2020-01-21 | PXD001954 | Pride
Salmonella typhi Hdmse Label free Mouse Caecum Tissue 
ProteomicsMultifactorial remodeling of the cancer immunopeptidome by interferon gamma
In this study we combined previous transcriptomics and immunopeptidomics data with new proteomics data from untreated and IFNg-treated CRC PDOs to dissect mechanisms that lead to remodeling of the immunopeptidome through IFNg treatment (this is from the paper introduction, let me know if it needs an...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD031634 | Pride
Human Immuno Tmtpro Cancer Hcd 
ProteomicsHip Osteoarthritis Functional Genomics
The aim of this work is to apply an integrated systems approach to understand the biological underpinnings of hip osteoarthritis that culminates in the need for total joint replacement (TJR). This study is a feasibility pilot that integrates functional genomics data from diseased and non-diseased ti...
ORGANISM(S): Homo sapiens (Human) 
2018-05-14 | PXD006673 | Pride
Hip Human Proteogenomics Osteoarthritis Lc-ms/ms 
ProteomicsCyclin B1-Cdk1 binds MAD1 and facilitates its release from the nuclear pore complex to ensure a robust Spindle Assembly Checkpoint
How the cell rapidly and completely reorganises its architecture when it divides is a problem that has fascinated for almost 150 years. We now know that the core regulatory machinery is highly conserved in eukaryotes but how these multiple protein kinases, protein phosphatases, and ubiquitin ligases...
ORGANISM(S): Homo sapiens (Human) 
2020-06-29 | PXD017202 | Pride
Human Ms3 Tmt 
ProteomicsProteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition
CDK4/6 inhibitor, Palbociclib, has shown a high success in breast cancer subtypes however it is often accompanied by a dependency on mutation status of cell lines. Consequently, there has been speculation on the breast cancer subtypes which should be offered treatment with specific CDK4/6 inhibitors...
ORGANISM(S): Homo sapiens (Human) 
2022-01-28 | PXD030407 | Pride
Tmt Phopho Ms/ms Secretome 
ProteomicsIntestinal crypt cells and the microbiome undergo abrupt reprogramming at the onset of colonic infection
We used the mouse pathogen Citrobacter rodentium to model gut infections. Following oral inoculation C. rodentium resides in the caecum for the first 3 days, before it infects the colon on the 4th day. Here we show that while the host is unresponsive to the infection on day 3, there is an abrupt rep...
ORGANISM(S): Citrobacter rodentium Mus musculus (Mouse) 
2019-03-05 | PXD012031 | Pride
Colon Infection Mouse Citrobacter Tmt 
UnknownCediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial.
Not available
S-EPMC4648082 | biostudies-literature
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