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ProteomicsYme1l substrate quantification under Leucine and Glutamine starvation as well as Torin treatment
Metabolic reprogramming of mitochondria occurs during development, cell differentiation and in cancer and is coupled to changes in mitochondrial mass and shape. Here, we demonstrate that the i-AAA protease YME1L rewires the proteome of pre-existing mitochondria in response to hypoxia or nutrient sta...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-21 | PXD014405 | Pride
Dia Mef cells Yme1l Lc-ms/ms 
ProteomicsProteomics analysis unravels new functions of the KICSTOR component SZT2
Developmental and epileptic encephalopathy is a group of rare, severe neurodevelopmental disorders characterized by the co-occurrence of epilepsy and intellectual disability (ID), in which there is additional developmental impairment independent of epileptic activity. In 2009, through a chemical mut...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD027662 | Pride
Szt2 Lysosome Mtorc1 Kicstor 
TranscriptomicsHybrid dysfunction and physiological compensation in gene expression
The formation of new species is often a consequence of genetic incompatibilities accumulated between populations during allopatric divergence. When divergent taxa interbreed, these incompatibilities impact physiology and have a direct cost resulting in reduced hybrid fitness. Recent surveys of gene ...
ORGANISM(S): Tigriopus californicus 
2015-01-05 | E-GEOD-62672 | biostudies-arrayexpress
ProteomicsQuantitative phosphoproteome of contracting C2 myotubes with pharmacological intervention of the PI3K-AKT-mTOR-S6K and RAF-MEK-ERK-RSK cascades
Various protein kinases are regulating the intracellular signaling network of skeletal muscle cells. Despite that many of the involved kinases are known, their downstream targets have remained largely unexplored. To deepen our understanding of the PI3K-AKT-mTOR-S6K and the RAF-MEK-ERK-RSK signaling ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-22 | PXD018667 | Pride
Phosphoproteomics Mouse Akt Rsk S6k Skeletal muscle Lc-ms/ms 
ProteomicsThe Prostate Cancer mTOR Chromatin-Bound Interactome
Growing studies support a direct role for nuclear mTOR in gene regulation and chromatin structure. Still, the scarcity of known chromatin-bound mTOR partners limits our understanding of how nuclear mTOR controls transcription. Herein, we comprehensively mapped the mTOR chromatin-bound interactome in...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD026101 | Pride
Human Prostate cancer Du145 Rime Normal prostate Rwpe-1 Lncap 22rv1 Mtor Chip-ms Pc3 
TranscriptomicsExpression of lignin-degrading enzymes in soils using targeted microarrays
Microarrays have become established tools for describing microbial systems, however the assessment of expression profiles for environmental microbial communities still presents unique challenges. Notably, the concentration of particular transcripts are likely very dilute relative to the pool of tot...
ORGANISM(S): Phanerochaete chrysosporium 
2010-05-18 | E-GEOD-13977 | biostudies-arrayexpress
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